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PHO87 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850403, updated on 11-Sep-2024

Summary

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Official Symbol
PHO87
Primary source
SGD:S000000633
Locus tag
YCR037C
See related
AllianceGenome:SGD:S000000633; FungiDB:YCR037C; VEuPathDB:YCR037C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables inorganic phosphate transmembrane transporter activity. Involved in anion transport; polyphosphate metabolic process; and regulation of phosphate transmembrane transport. Located in plasma membrane. Orthologous to several human genes including SLC13A3 (solute carrier family 13 member 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: III
Exon count:
1
Sequence:
Chromosome: III; NC_001135.5 (194414..197185, complement)

Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene exosome non-catalytic core subunit RRP43 Neighboring gene putative ribokinase Neighboring gene Ras family guanine nucleotide exchange factor BUD5 Neighboring gene homeodomain mating type protein alpha2 Neighboring gene transcriptional co-activator mating type protein alpha Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001135.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A putative new membrane protein, Pho86p, in the inorganic phosphate uptake system of Saccharomyces cerevisiae. Yompakdee C, et al. Gene, 1996 May 24. PMID 8675028
  2. Two new genes, PHO86 and PHO87, involved in inorganic phosphate uptake in Saccharomyces cerevisiae. Bun-ya M, et al. Curr Genet, 1996 Mar. PMID 8598055
  3. The SPX domain of the yeast low-affinity phosphate transporter Pho90 regulates transport activity. Hürlimann HC, et al. EMBO Rep, 2009 Sep. PMID 19590579, Free PMC Article
  4. Ddi1p and Rad23p play a cooperative role as negative regulators in the PHO pathway in Saccharomyces cerevisiae. Auesukaree C, et al. Biochem Biophys Res Commun, 2008 Jan 25. PMID 18035052
  5. Transcriptional regulation of phosphate-responsive genes in low-affinity phosphate-transporter-defective mutants in Saccharomyces cerevisiae. Auesukaree C, et al. Biochem Biophys Res Commun, 2003 Jul 11. PMID 12821119

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables phosphate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphate transmembrane transporter activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in phosphate ion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphate ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphate ion transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in plasma membrane selenite transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in polyphosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in polyphosphate metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of phosphate transmembrane transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell periphery HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
SPX domain-containing inorganic phosphate transporter
NP_009966.2
  • Low-affinity inorganic phosphate (Pi) transporter; acts upstream of Pho81p in regulation of PHO pathway; targeted to vacuole via AP-3 pathway; expression is independent of Pi concentration and Pho4p activity; contains 12 membrane-spanning segments; PHO87 has a paralog, PHO90, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001135.5 Reference assembly

    Range
    194414..197185 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178751.1 → NP_009966.2  TPA: SPX domain-containing inorganic phosphate transporter [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009966.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VR47, P25360
    UniProtKB/TrEMBL
    B3LUA6, C8Z4C7, N1PAQ5
    Conserved Domains (2) summary
    COG5408
    Location:1 → 334
    COG5408; SPX domain-containing protein [Signal transduction mechanisms]
    cd01115
    Location:487 → 914
    SLC13_permease; Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25360.2

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