SNT1 Snt1p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: SNT1
Official Full Name: Snt1p
Primary source: SGD:S000000629
Locus tag: YCR033W
See related: AllianceGenome:SGD:S000000629; FungiDB:YCR033W; VEuPathDB:YCR033W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Predicted to enable DNA binding activity. Involved in positive regulation of stress-activated MAPK cascade and regulation of DNA-templated transcription. Located in cytosol and nucleus. Part of Set3 complex. Human ortholog(s) of this gene implicated in osteoarthritis. Orthologous to human NCOR1 (nuclear receptor corepressor 1) and NCOR2 (nuclear receptor corepressor 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See SNT1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 1

Sequence:: Chromosome: III; NC_001135.5 (186489..190169)

Chromosome III - NC_001135.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001135.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A Prion Epigenetic Switch Establishes an Active Chromatin State.
Title: A Prion Epigenetic Switch Establishes an Active Chromatin State.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in positive regulation of stress-activated MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of Rpd3L-Expanded complex	HDA more info	PubMed
part_of Set3 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Set3 complex	IDA Inferred from Direct Assay more info	PubMed
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Snt1p

NP_009962.2

Set3C histone deacetylase scaffold; can act as prion [ESI+] (Expressed Subtelomeric Information) that drives emergence and transgenerational inheritance of activated chromatin state; prion conformer is triggered by transient Snt1p phosphorylation upon cell cycle arrest; [ESI+] reshapes the activity Set3C, recruiting RNAPII, interfering with Rap1p binding to activate genes in otherwise repressed subtelomeric domains; relocalizes to cytosol in response to hypoxia

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001135.5 Reference assembly

Range

186489..190169

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178747.1 → NP_009962.2 TPA: Snt1p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_009962.2

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VR43, P25357, Q02397, Q8NIL8

UniProtKB/TrEMBL

C8Z4C3, N1P849

Conserved Domains (5) summary

PHA03255
Location:62 → 173

PHA03255; BDLF3; Provisional

COG5116
Location:715 → 803

RPN2; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]

PRK03918
Location:348 → 588

PRK03918; DNA double-strand break repair ATPase Rad50

cd00167
Location:672 → 716

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam00249
Location:892 → 933

Myb_DNA-binding; Myb-like DNA-binding domain