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CWH43 Cwh43p [ Saccharomyces cerevisiae S288C ]

Gene ID: 850376, updated on 2-Nov-2024

Summary

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Official Symbol
CWH43
Official Full Name
Cwh43p
Primary source
SGD:S000000610
Locus tag
YCR017C
See related
AllianceGenome:SGD:S000000610; FungiDB:YCR017C; VEuPathDB:YCR017C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in GPI anchor biosynthetic process and fungal-type cell wall organization. Located in cellular bud neck; cellular bud tip; and plasma membrane. Orthologous to human CWH43 (cell wall biogenesis 43 C-terminal homolog). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See CWH43 in Genome Data Viewer
Location:
chromosome: III
Exon count:
1
Sequence:
Chromosome: III; NC_001135.5 (144773..147634, complement)

Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene tRNA-Gly Neighboring gene RNA-binding ribosome assembly factor RBP95 Neighboring gene Srd1p Neighboring gene tRNA-Met

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001135.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Saccharomyces cerevisiae CWH43 is involved in the remodeling of the lipid moiety of GPI anchors to ceramides. Umemura M, et al. Mol Biol Cell, 2007 Nov. PMID 17761529, Free PMC Article
  2. CWH43 is required for the introduction of ceramides into GPI anchors in Saccharomyces cerevisiae. Ghugtyal V, et al. Mol Microbiol, 2007 Sep. PMID 17714445
  3. KNR4, a suppressor of Saccharomyces cerevisiae cwh mutants, is involved in the transcriptional control of chitin synthase genes. Martin H, et al. Microbiology (Reading), 1999 Jan. PMID 10206705
  4. Lipid moiety of glycosylphosphatidylinositol-anchored proteins contributes to the determination of their final destination in yeast. Yoko-O T, et al. Genes Cells, 2018 Oct. PMID 30133879
  5. Incorporation of ceramides into Saccharomyces cerevisiae glycosylphosphatidylinositol-anchored proteins can be monitored in vitro. Bosson R, et al. Eukaryot Cell, 2009 Mar. PMID 19074599, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in GPI anchor biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in GPI anchor biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in GPI anchor biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in GPI anchor metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in fungal-type cell wall organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fungal-type cell wall organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cellular bud neck IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cellular bud tip IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum HDA PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Cwh43p
NP_009943.2
  • GPI lipid remodelase; responsible for introducing ceramides into GPI anchors having a C26:0 fatty acid in sn-2 of the glycerol moiety; can also use lyso-GPI protein anchors and various base resistant lipids as substrates; contains 14-16 transmembrane segments and several putative glycosylation and phosphorylation sites; null mutation is synthetically lethal with pkc1 deletion

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001135.5 Reference assembly

    Range
    144773..147634 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178730.1 → NP_009943.2  TPA: Cwh43p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009943.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VR25, P25618, Q8NIM1
    UniProtKB/TrEMBL
    C7GT44, C8Z4A4, N1P689
    Conserved Domains (2) summary
    pfam03372
    Location:701 → 911
    Exo_endo_phos; Endonuclease/Exonuclease/phosphatase family
    pfam10277
    Location:5 → 207
    Frag1; Frag1/DRAM/Sfk1 family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25618.2

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