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CDC10 septin CDC10 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850358, updated on 3-Nov-2024

Summary

Official Symbol
CDC10
Official Full Name
septin CDC10
Primary source
SGD:S000000595
Locus tag
YCR002C
See related
AllianceGenome:SGD:S000000595; FungiDB:YCR002C; VEuPathDB:YCR002C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables GTPase activity; molecular adaptor activity; and phosphatidylinositol binding activity. A structural constituent of cytoskeleton. Involved in several processes, including exit from mitosis; mitotic cytokinesis; and septin ring assembly. Located in cytoskeleton; mating projection base; and prospore membrane. Part of septin complex. Human ortholog(s) of this gene implicated in brachial plexus neuritis; colorectal cancer; and spermatogenic failure 10. Orthologous to several human genes including SEPTIN3 (septin 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

See CDC10 in Genome Data Viewer
Location:
chromosome: III
Exon count:
1
Sequence:
Chromosome: III; NC_001135.5 (117380..118348, complement)

Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene mitochondrial 54S ribosomal protein YmL32 Neighboring gene flavodoxin-like fold family protein

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 1-phosphatidylinositol binding IDA
Inferred from Direct Assay
more info
PubMed 
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables molecular adaptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatidylinositol-4-phosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatidylinositol-5-phosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
enables structural constituent of cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in cytoskeleton-dependent cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in exit from mitosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitotic cytokinesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in septin ring assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sporulation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in ascospore-type prospore IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cell division site IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cellular bud neck HDA PubMed 
located_in cellular bud neck IEA
Inferred from Electronic Annotation
more info
 
located_in cellular bud neck septin ring IDA
Inferred from Direct Assay
more info
PubMed 
located_in mating projection base IDA
Inferred from Direct Assay
more info
PubMed 
located_in mating projection tip HDA PubMed 
located_in meiotic spindle IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in prospore membrane HDA PubMed 
located_in prospore membrane IDA
Inferred from Direct Assay
more info
PubMed 
part_of septin complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of septin complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of septin complex IEA
Inferred from Electronic Annotation
more info
 
part_of septin complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in septin filament array IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in septin ring IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in spindle microtubule IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
septin CDC10
NP_009928.1
  • Component of the septin ring, required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells; N-terminus interacts with phosphatidylinositol-4,5-bisphosphate; protein abundance increases under DNA damage stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001135.5 Reference assembly

    Range
    117380..118348 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178715.1NP_009928.1  TPA: septin CDC10 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009928.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VR12, P25342
    UniProtKB/TrEMBL
    A6ZTI4, B3LU74, B5VEV0, C7GQL5, C8Z487, G2WA20, N1P684
    Conserved Domains (1) summary
    COG5019
    Location:11322
    CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]