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DCC1 Dcc1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 850344, updated on 3-Nov-2024

Summary

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Official Symbol
DCC1
Official Full Name
Dcc1p
Primary source
SGD:S000000521
Locus tag
YCL016C
See related
AllianceGenome:SGD:S000000521; FungiDB:YCL016C; VEuPathDB:YCL016C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in maintenance of DNA trinucleotide repeats and mitotic sister chromatid cohesion. Acts upstream of or within telomere tethering at nuclear periphery. Part of Ctf18 RFC-like complex. Orthologous to human DSCC1 (DNA replication and sister chromatid cohesion 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See DCC1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
1
Sequence:
Chromosome: III; NC_001135.5 (94621..95763, complement)

Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene 3-isopropylmalate dehydrogenase Neighboring gene cysteine desulfurase Neighboring gene Bud3p Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001135.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mft1, identified from a genome-wide screen of the yeast haploid mutants, mediates cell cycle arrest to counteract quinoxaline-induced toxicity. Sulaiman AA, et al. Front Genet, 2023. PMID 38283148, Free PMC Article
  2. The Ctf18 RFC-like complex positions yeast telomeres but does not specify their replication time. Hiraga S, et al. EMBO J, 2006 Apr 5. PMID 16525505, Free PMC Article
  3. Sister-chromatid cohesion mediated by the alternative RF-CCtf18/Dcc1/Ctf8, the helicase Chl1 and the polymerase-alpha-associated protein Ctf4 is essential for chromatid disjunction during meiosis II. Petronczki M, et al. J Cell Sci, 2004 Jul 15. PMID 15226378
  4. Conserved interaction of Ctf18-RFC with DNA polymerase ε is critical for maintenance of genome stability in Saccharomyces cerevisiae. Okimoto H, et al. Genes Cells, 2016 May. PMID 26987677
  5. X-ray survival characteristics and genetic analysis for nine Saccharomyces deletion mutants that show altered radiation sensitivity. Game JC, et al. Genetics, 2005 Jan. PMID 15371366, Free PMC Article

See all (112) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in maintenance of DNA trinucleotide repeats IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in maintenance of mitotic sister chromatid cohesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic sister chromatid cohesion IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic sister chromatid cohesion IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in mitotic sister chromatid cohesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within telomere tethering at nuclear periphery IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Ctf18 RFC-like complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Ctf18 RFC-like complex IEA
Inferred from Electronic Annotation
more info
  
part_of Ctf18 RFC-like complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in chromosome, centromeric region IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Dcc1p
NP_009913.2
  • Subunit of a complex with Ctf8p and Ctf18p; shares some components with Replication Factor C; required for sister chromatid cohesion and telomere length maintenance

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001135.5 Reference assembly

    Range
    94621..95763 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178663.1 → NP_009913.2  TPA: Dcc1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009913.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQZ8, P25559, Q8NIM7
    UniProtKB/TrEMBL
    A6ZTH0, C7GQK4, C8Z471, G2WA06, N1P672
    Conserved Domains (1) summary
    pfam09724
    Location:15 → 348
    Dcc1; Sister chromatid cohesion protein Dcc1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25559.2

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