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MGR1 Mgr1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 850313, updated on 2-Nov-2024

Summary

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Official Symbol
MGR1
Official Full Name
Mgr1p
Primary source
SGD:S000000549
Locus tag
YCL044C
See related
AllianceGenome:SGD:S000000549; FungiDB:YCL044C; VEuPathDB:YCL044C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables misfolded protein binding activity. Involved in protein quality control for misfolded or incompletely synthesized proteins. Located in mitochondrion. Part of i-AAA complex. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See MGR1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
1
Sequence:
Chromosome: III; NC_001135.5 (47111..48364, complement)

Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene nicotinamide-nucleotide adenylyltransferase Neighboring gene Emc1p Neighboring gene protein disulfide isomerase PDI1 Neighboring gene uncharacterized protein Neighboring gene glucokinase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001135.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mitochondrial inner-membrane protease Yme1 degrades outer-membrane proteins Tom22 and Om45. Wu X, et al. J Cell Biol, 2018 Jan 2. PMID 29138251, Free PMC Article
  2. Metabolic and environmental conditions determine nuclear genomic instability in budding yeast lacking mitochondrial DNA. Dirick L, et al. G3 (Bethesda), 2014 Mar 20. PMID 24374640, Free PMC Article
  3. Defects associated with mitochondrial DNA damage can be mitigated by increased vacuolar pH in Saccharomyces cerevisiae. Garipler G, et al. Genetics, 2013 May. PMID 23502676, Free PMC Article
  4. A genomewide screen for petite-negative yeast strains yields a new subunit of the i-AAA protease complex. Dunn CD, et al. Mol Biol Cell, 2006 Jan. PMID 16267274, Free PMC Article
  5. Mgr3p and Mgr1p are adaptors for the mitochondrial i-AAA protease complex. Dunn CD, et al. Mol Biol Cell, 2008 Dec. PMID 18843051, Free PMC Article

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables misfolded protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein quality control for misfolded or incompletely synthesized proteins IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of i-AAA complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Mgr1p
NP_009886.1
  • Subunit of the mitochondrial (mt) i-AAA protease supercomplex; i-AAA degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr3p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001135.5 Reference assembly

    Range
    47111..48364 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178689.1 → NP_009886.1  TPA: Mgr1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009886.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A6ZTE8, D6VQX2, P25573
    UniProtKB/TrEMBL
    B3LU40, B5VER7, C7GSZ9, C8Z446, N1P982
    Conserved Domains (1) summary
    pfam08602
    Location:1 → 388
    Mgr1; Mgr1-like, i-AAA protease complex subunit
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25573.1

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