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LRE1 Lre1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 850306, updated on 2-Nov-2024

Summary

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Official Symbol
LRE1
Official Full Name
Lre1p
Primary source
SGD:S000000556
Locus tag
YCL051W
See related
AllianceGenome:SGD:S000000556; FungiDB:YCL051W; VEuPathDB:YCL051W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables protein kinase inhibitor activity. Involved in fungal-type cell wall organization. Located in cellular bud neck. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See LRE1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
1
Sequence:
Chromosome: III; NC_001135.5 (35865..37616)

Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene 27S pre-rRNA (guanosine2922-2'-O)-methyltransferase Neighboring gene Pbn1p Neighboring gene bifunctional AP-4-A phosphorylase/ADP sulfurylase Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001135.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Lre1 accumulates at the cell division site in late anaphase and associates with both Mob2 and Cbk1 in vivo and in vitro.
    Title: Lre1 directly inhibits the NDR/Lats kinase Cbk1 at the cell division site in a phosphorylation-dependent manner.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables protein kinase inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein kinase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in fungal-type cell wall organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in fungal-type cell wall organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cellular bud neck IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Lre1p
NP_009879.2
  • Protein involved in control of cell wall structure and stress response; direct inhibitor of the nuclear Dbf2 related (NDR) kinase Cbk1p-Mob2p; overproduction confers resistance to cell-wall degrading enzymes; exhibits genetic interactions with genes involved in the cell wall integrity pathway; LRE1 has a paralog, HLR1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001135.5 Reference assembly

    Range
    35865..37616
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178696.1 → NP_009879.2  TPA: Lre1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009879.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQW5, P25579
    UniProtKB/TrEMBL
    A6ZTE3, B3LU33, C8Z438
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25579.2

Gene LinkOut

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