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ZNF577 zinc finger protein 577 [ Homo sapiens (human) ]

Gene ID: 84765, updated on 2-Nov-2024

Summary

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Official Symbol
ZNF577provided by HGNC
Official Full Name
zinc finger protein 577provided by HGNC
Primary source
HGNC:HGNC:28673
See related
Ensembl:ENSG00000161551 AllianceGenome:HGNC:28673
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in skin (RPKM 6.4), ovary (RPKM 5.9) and 25 other tissues See more
Orthologs
all
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Genomic context

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See ZNF577 in Genome Data Viewer
Location:
19q13.41
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (51804442..51887951, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (54889344..54975146, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (52307695..52391204, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 3543 Neighboring gene formyl peptide receptor 2 Neighboring gene uncharacterized LOC105372448 Neighboring gene formyl peptide receptor 3 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr19:52350575-52351774 Neighboring gene zinc finger protein 84 pseudogene Neighboring gene vomeronasal 1 receptor 98 pseudogene Neighboring gene NANOG hESC enhancer GRCh37_chr19:52382957-52383477 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:52390477-52391328 Neighboring gene ZNF649 antisense RNA 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:52404806-52405052 Neighboring gene zinc finger protein 649 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:52406403-52406948 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:52408039-52408583 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr19:52408912-52409536 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr19:52410420-52411095 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:52411096-52411770 Neighboring gene zinc finger protein 41 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. ZNF577 Methylation Levels in Leukocytes From Women With Breast Cancer Is Modulated by Adiposity, Menopausal State, and the Mediterranean Diet. Lorenzo PM, et al. Front Endocrinol (Lausanne), 2020. PMID 32390948, Free PMC Article
  2. Potential novel candidate polymorphisms identified in genome-wide association study for breast cancer susceptibility. Sehrawat B, et al. Hum Genet, 2011 Oct. PMID 21424380, Free PMC Article
  3. The interactome of KRAB zinc finger proteins reveals the evolutionary history of their functional diversification. Helleboid PY, et al. EMBO J, 2019 Sep 16. PMID 31403225, Free PMC Article
  4. Protein interaction discovery using parallel analysis of translated ORFs (PLATO). Zhu J, et al. Nat Biotechnol, 2013 Apr. PMID 23503679, Free PMC Article
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZNF577 Methylation Levels in Leukocytes From Women With Breast Cancer Is Modulated by Adiposity, Menopausal State, and the Mediterranean Diet.
    Title: ZNF577 Methylation Levels in Leukocytes From Women With Breast Cancer Is Modulated by Adiposity, Menopausal State, and the Mediterranean Diet.
  2. Single nucleotide polymorphisms in ZNF577 gene is associated with breast cancer.
    Title: Potential novel candidate polymorphisms identified in genome-wide association study for breast cancer susceptibility.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Potential novel candidate polymorphisms identified in genome-wide association study for breast cancer susceptibility.
EBI GWAS Catalog

Variation

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See Variation Viewer (GRCh37.p13)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC4400, FLJ32291, AC006272.1

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 577

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135590.2 → NP_001129062.1  zinc finger protein 577 isoform b

    See identical proteins and their annotated locations for NP_001129062.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The resulting isoform (b) is shorter than isoform a.
    Source sequence(s)
    AC011460, AC074141, AK289479, AK291812, BC004992, BU949047
    Consensus CDS
    CCDS46160.1
    UniProtKB/TrEMBL
    A0A1W2PQ54
    Related
    ENSP00000389652.2, ENST00000451628.9
    Conserved Domains (3) summary
    smart00349
    Location:25 → 83
    KRAB; krueppel associated box
    COG5048
    Location:135 → 340
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:157 → 177
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_001370447.1 → NP_001357376.1  zinc finger protein 577 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC074141, AI004737, AK289479, DA747815
    Consensus CDS
    CCDS12842.2
    UniProtKB/Swiss-Prot
    A8K0B4, A8K6Z7, C9JFB9, Q9BSK1
    UniProtKB/TrEMBL
    A0A1W2PQ54
    Conserved Domains (3) summary
    smart00349
    Location:25 → 83
    KRAB; krueppel associated box
    COG5048
    Location:194 → 399
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:216 → 236
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. NM_001370448.1 → NP_001357377.1  zinc finger protein 577 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC074141, AI004737, AK289479, DA747815, DA874803
    Consensus CDS
    CCDS12842.2
    UniProtKB/Swiss-Prot
    A8K0B4, A8K6Z7, C9JFB9, Q9BSK1
    UniProtKB/TrEMBL
    A0A1W2PQ54
    Conserved Domains (3) summary
    smart00349
    Location:25 → 83
    KRAB; krueppel associated box
    COG5048
    Location:194 → 399
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:216 → 236
    ZF_C2H2; C2H2 Zn finger [structural motif]

  4. NM_001370449.1 → NP_001357378.1  zinc finger protein 577 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC074141, AI004737, AK093036, AK289479, AL832871
    Consensus CDS
    CCDS12842.2
    UniProtKB/Swiss-Prot
    A8K0B4, A8K6Z7, C9JFB9, Q9BSK1
    UniProtKB/TrEMBL
    A0A1W2PQ54
    Related
    ENSP00000491936.2, ENST00000638348.2
    Conserved Domains (3) summary
    smart00349
    Location:25 → 83
    KRAB; krueppel associated box
    COG5048
    Location:194 → 399
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:216 → 236
    ZF_C2H2; C2H2 Zn finger [structural motif]

  5. NM_001370450.1 → NP_001357379.1  zinc finger protein 577 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC074141, AI004737, AK093036, AK289479, AK291812, AL832871
    Consensus CDS
    CCDS46160.1
    UniProtKB/TrEMBL
    A0A1W2PQ54
    Related
    ENSP00000491349.1, ENST00000639636.2
    Conserved Domains (3) summary
    smart00349
    Location:25 → 83
    KRAB; krueppel associated box
    COG5048
    Location:135 → 340
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:157 → 177
    ZF_C2H2; C2H2 Zn finger [structural motif]

  6. NM_001370452.1 → NP_001357381.1  zinc finger protein 577 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC006272, AC011460, AC074141
    UniProtKB/TrEMBL
    A0A1W2PRX5
    Conserved Domains (1) summary
    smart00349
    Location:25 → 83
    KRAB; krueppel associated box

  7. NM_001370455.1 → NP_001357384.1  zinc finger protein 577 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC006272, AC011460, AC074141
    UniProtKB/TrEMBL
    A0A1W2PRX5
    Conserved Domains (1) summary
    smart00349
    Location:25 → 83
    KRAB; krueppel associated box

  8. NM_001370456.1 → NP_001357385.1  zinc finger protein 577 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC006272, AC011460, AC074141
    UniProtKB/TrEMBL
    A0A1W2PRX5
    Conserved Domains (1) summary
    smart00349
    Location:25 → 83
    KRAB; krueppel associated box

  9. NM_001370457.1 → NP_001357386.1  zinc finger protein 577 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC006272, AC011460, AC074141
    UniProtKB/TrEMBL
    A0A1W2PRX5
    Related
    ENSP00000492704.1, ENST00000638827.1
    Conserved Domains (1) summary
    smart00349
    Location:25 → 83
    KRAB; krueppel associated box

  10. NM_032679.3 → NP_116068.2  zinc finger protein 577 isoform a

    See identical proteins and their annotated locations for NP_116068.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC074141, AK289479, BC004992, BU949047
    Consensus CDS
    CCDS12842.2
    UniProtKB/Swiss-Prot
    A8K0B4, A8K6Z7, C9JFB9, Q9BSK1
    UniProtKB/TrEMBL
    A0A1W2PQ54
    Related
    ENSP00000301399.5, ENST00000301399.12
    Conserved Domains (3) summary
    smart00349
    Location:25 → 83
    KRAB; krueppel associated box
    COG5048
    Location:194 → 399
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:216 → 236
    ZF_C2H2; C2H2 Zn finger [structural motif]

RNA

  1. NR_163433.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC005946, AC006272, AC011460, AC074141

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    51804442..51887951 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047439551.1 → XP_047295507.1  zinc finger protein 577 isoform X2

  2. XM_047439550.1 → XP_047295506.1  zinc finger protein 577 isoform X1

    UniProtKB/Swiss-Prot
    A8K0B4, A8K6Z7, C9JFB9, Q9BSK1

RNA

  1. XR_007067021.1 RNA Sequence

  2. XR_007067020.1 RNA Sequence

  3. XR_007067019.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    54889344..54975146 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054322405.1 → XP_054178380.1  zinc finger protein 577 isoform X2

  2. XM_054322404.1 → XP_054178379.1  zinc finger protein 577 isoform X1

    UniProtKB/Swiss-Prot
    A8K0B4, A8K6Z7, C9JFB9, Q9BSK1

RNA

  1. XR_008485211.1 RNA Sequence

  2. XR_008485213.1 RNA Sequence

  3. XR_008485212.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BSK1.3 GenPept UniProtKB/Swiss-Prot:Q9BSK1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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