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OGT O-linked N-acetylglucosamine (GlcNAc) transferase [ Homo sapiens (human) ]

Gene ID: 8473, updated on 7-Apr-2024

Summary

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Official Symbol
OGTprovided by HGNC
Official Full Name
O-linked N-acetylglucosamine (GlcNAc) transferaseprovided by HGNC
Primary source
HGNC:HGNC:8127
See related
Ensembl:ENSG00000147162 MIM:300255; AllianceGenome:HGNC:8127
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OGT1; HRNT1; MRX106; XLID106; HINCUT-1; O-GLCNAC
Summary
This gene encodes a glycosyltransferase that catalyzes the addition of a single N-acetylglucosamine in O-glycosidic linkage to serine or threonine residues. Since both phosphorylation and glycosylation compete for similar serine or threonine residues, the two processes may compete for sites, or they may alter the substrate specificity of nearby sites by steric or electrostatic effects. The protein contains multiple tetratricopeptide repeats that are required for optimal recognition of substrates. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Expression
Ubiquitous expression in lymph node (RPKM 56.6), spleen (RPKM 53.1) and 25 other tissues See more
Orthologs
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Genomic context

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See OGT in Genome Data Viewer
Location:
Xq13.1
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (71533104..71575892)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (69966355..70009143)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (70752954..70795742)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene TATA-box binding protein associated factor 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20898 Neighboring gene inhibitor of growth family, X-linked (pseudogene) Neighboring gene MED14-independent group 3 enhancer GRCh37_chrX:70752005-70753204 Neighboring gene SOCS6 pseudogene 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:70798494-70799135 Neighboring gene germ cell nuclear acidic peptidase Neighboring gene Sharpr-MPRA regulatory region 14051 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29745 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29746 Neighboring gene C-X-C motif chemokine receptor 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. O-GlcNAc transferase contributes to sex-specific placental deregulation in gestational diabetes. Cui Y, et al. Placenta, 2023 Jan. PMID 36442303, Free PMC Article
  2. Inhibition of O-GlcNAc Transferase Alters the Differentiation and Maturation Process of Human Monocyte Derived Dendritic Cells. Weiss M, et al. Cells, 2021 Nov 26. PMID 34943826, Free PMC Article
  3. Feedback Regulation of O-GlcNAc Transferase through Translation Control to Maintain Intracellular O-GlcNAc Homeostasis. Lin CH, et al. Int J Mol Sci, 2021 Mar 27. PMID 33801653, Free PMC Article
  4. Inhibition of mechanistic target of rapamycin signaling decreases levels of O-GlcNAc transferase and increases serotonin release in the human placenta. Kelly AC, et al. Clin Sci (Lond), 2020 Dec 11. PMID 33215629, Free PMC Article
  5. Epigenetic activation of O-linked β-N-acetylglucosamine transferase overrides the differentiation blockage in acute leukemia. Kampa-Schittenhelm KM, et al. EBioMedicine, 2020 Apr. PMID 32272438, Free PMC Article

See all (332) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cryo-EM structure of human O-GlcNAcylation enzyme pair OGT-OGA complex.
    Title: Cryo-EM structure of human O-GlcNAcylation enzyme pair OGT-OGA complex.
  2. Motif-dependent binding on the intervening domain regulates O-GlcNAc transferase.
    Title: Motif-dependent binding on the intervening domain regulates O-GlcNAc transferase.
  3. Chromatin-associated OGT promotes the malignant progression of hepatocellular carcinoma by activating ZNF263.
    Title: Chromatin-associated OGT promotes the malignant progression of hepatocellular carcinoma by activating ZNF263.
  4. LncRNA EBLN3P attributes methotrexate resistance in osteosarcoma cells through miR-200a-3p/O-GlcNAc transferase pathway.
    Title: LncRNA EBLN3P attributes methotrexate resistance in osteosarcoma cells through miR-200a-3p/O-GlcNAc transferase pathway.
  5. O-GlcNAc transferase contributes to sex-specific placental deregulation in gestational diabetes.
    Title: O-GlcNAc transferase contributes to sex-specific placental deregulation in gestational diabetes.
  6. O-GlcNAc transferase regulates p21 protein levels and cell proliferation through the FoxM1-Skp2 axis in a p53-independent manner.
    Title: O-GlcNAc transferase regulates p21 protein levels and cell proliferation through the FoxM1-Skp2 axis in a p53-independent manner.
  7. EGF promotes PKM2 O-GlcNAcylation by stimulating O-GlcNAc transferase phosphorylation at Y976 and their subsequent association.
    Title: EGF promotes PKM2 O-GlcNAcylation by stimulating O-GlcNAc transferase phosphorylation at Y976 and their subsequent association.
  8. O-GlcNAc transferase regulates glioblastoma acetate metabolism via regulation of CDK5-dependent ACSS2 phosphorylation.
    Title: O-GlcNAc transferase regulates glioblastoma acetate metabolism via regulation of CDK5-dependent ACSS2 phosphorylation.
  9. P53 suppresses the progression of hepatocellular carcinoma via miR-15a by decreasing OGT expression and EZH2 stabilization.
    Title: P53 suppresses the progression of hepatocellular carcinoma via miR-15a by decreasing OGT expression and EZH2 stabilization.
  10. Upregulation of OGT by Caveolin-1 promotes hepatocellular carcinoma cell migration and invasion.
    Title: Upregulation of OGT by Caveolin-1 promotes hepatocellular carcinoma cell migration and invasion.
Submit: New GeneRIF Correction See all GeneRIFs (144)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Intellectual disability, X-linked 106
MedGen: C4478379 OMIM: 300997 GeneReviews: Not available
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Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ23071, MGC22921

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables acetylglucosaminyltransferase activity TAS
Traceable Author Statement
more info
 PubMed 
enables chromatin DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-3,4,5-trisphosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein O-acetylglucosaminyltransferase activity EXP
Inferred from Experiment
more info
 PubMed 
enables protein O-acetylglucosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein O-acetylglucosaminyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein O-acetylglucosaminyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein O-acetylglucosaminyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to glucose stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in circadian regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in hemopoiesis ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in mitophagy ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in negative regulation of cell migration NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of stem cell population maintenance NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of transforming growth factor beta receptor signaling pathway NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of TORC1 signaling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in positive regulation of lipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of proteolysis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of stem cell population maintenance NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription from RNA polymerase II promoter by glucose IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of translation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein O-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein O-linked glycosylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein O-linked glycosylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of Rac protein signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of gluconeogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of glycolytic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of insulin receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of necroptotic process TAS
Traceable Author Statement
more info
  
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of synapse assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to insulin IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to nutrient TAS
Traceable Author Statement
more info
 PubMed 
involved_in signal transduction TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of NSL complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
  
part_of histone acetyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein N-acetylglucosaminyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
Names
O-GlcNAc transferase p110 subunit
O-GlcNAc transferase subunit p110
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
O-linked N-acetylglucosamine transferase 110 kDa subunit
UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase
uridinediphospho-N-acetylglucosamine:polypeptide beta-N-acetylglucosaminyl transferase
NP_858058.1
NP_858059.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_015875.1 RefSeqGene

    Range
    5043..47831
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_181672.3 → NP_858058.1  UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform 1

    See identical proteins and their annotated locations for NP_858058.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AF070560, BC038180, BX537844, DA460761
    Consensus CDS
    CCDS14414.1
    UniProtKB/Swiss-Prot
    O15294, Q7Z3K0, Q8WWM8, Q96CC1, Q9UG57
    UniProtKB/TrEMBL
    A0A8V8TPA3
    Related
    ENSP00000362824.3, ENST00000373719.8
    Conserved Domains (3) summary
    TIGR02917
    Location:22 → 465
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:327 → 355
    TPR; TPR repeat [structural motif]
    pfam13844
    Location:556 → 1024
    Glyco_transf_41; Glycosyl transferase family 41

  2. NM_181673.3 → NP_858059.1  UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform 2

    See identical proteins and their annotated locations for NP_858059.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. This results in a shorter protein (isoform 2) compared to isoform 1.
    Source sequence(s)
    BC014434, BX537844, DA460761
    Consensus CDS
    CCDS35502.1
    UniProtKB/TrEMBL
    A0A8V8TPA3
    Related
    ENSP00000362805.3, ENST00000373701.7
    Conserved Domains (3) summary
    TIGR02917
    Location:23 → 455
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:317 → 345
    TPR; TPR repeat [structural motif]
    pfam13844
    Location:546 → 1014
    Glyco_transf_41; Glycosyl transferase family 41

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    71533104..71575892
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    69966355..70009143
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_003605.3: Suppressed sequence

    Description
    NM_003605.3: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.

  2. NM_025192.1: Suppressed sequence

    Description
    NM_025192.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O15294.3 GenPept UniProtKB/Swiss-Prot:O15294

Gene LinkOut

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