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PSRC1 proline and serine rich coiled-coil 1 [ Homo sapiens (human) ]

Gene ID: 84722, updated on 2-Nov-2024

Summary

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Official Symbol
PSRC1provided by HGNC
Official Full Name
proline and serine rich coiled-coil 1provided by HGNC
Primary source
HGNC:HGNC:24472
See related
Ensembl:ENSG00000134222 MIM:613126; AllianceGenome:HGNC:24472
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DDA3; FP3214
Summary
This gene encodes a proline-rich protein that is a target for regulation by the tumor suppressor protein p53. The encoded protein plays an important role in mitosis by recruiting and regulating microtubule depolymerases that destabalize microtubules. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Apr 2014]
Expression
Broad expression in brain (RPKM 9.0), testis (RPKM 4.6) and 23 other tissues See more
Orthologs
mouse all
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Genomic context

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See PSRC1 in Genome Data Viewer
Location:
1p13.3
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (109279556..109283145, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (109312356..109315945, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (109822178..109825767, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1143 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1437 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:109767996-109768680 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:109768681-109769365 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:109772336-109773132 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:109773133-109773930 Neighboring gene seryl-tRNA synthetase 1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:109779623-109780822 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:109781947-109782361 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:109782763-109783458 Neighboring gene Sharpr-MPRA regulatory region 12007 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:109785117-109785616 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:109791478-109792198 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1144 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1145 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:109793618-109793808 Neighboring gene VISTA enhancer hs2216 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:109802367-109802915 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:109803429-109803928 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:109806365-109807347 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:109807766-109807952 Neighboring gene cadherin EGF LAG seven-pass G-type receptor 2 Neighboring gene VISTA enhancer hs2263 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:109820047-109820796 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:109826136-109826861 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:109839316-109839887 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:109842955-109843465 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:109843466-109843975 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:109849151-109849890 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:109849891-109850629 Neighboring gene myosin binding protein H like Neighboring gene MPRA-validated peak354 silencer Neighboring gene sortilin 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1147 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1148 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1149

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Genetically programmed changes in transcription of the novel progranulin regulator.
    Title: Genetically programmed changes in transcription of the novel progranulin regulator.
  2. Association of the PSRC1 rs599839 Variant with Coronary Artery Disease in a Mexican Population.
    Title: Association of the PSRC1 rs599839 Variant with Coronary Artery Disease in a Mexican Population.
  3. Reciprocal regulation of Aurora kinase A and ATIP3 in the control of metaphase spindle length.
    Title: Reciprocal regulation of Aurora kinase A and ATIP3 in the control of metaphase spindle length.
  4. the frequency of SNP rs599839 located in the 3' UTR of the PSRC1 gene in patients with genetically confirmed diagnosis of heterozygous familial hypercholesterolemia was analyzed. It was found that there was no association between rs599839 alleles and coronary heart disease in the multivariate analysis.
    Title: Multivariate analysis for coronary heart disease in heterozygote familial hypercholesterolemia patients.
  5. Mdp3 (also known as MAP7D3) forms a complex with DDA3 (also known as PSRC1) and controls spindle dynamics at the minus end of Microtubuless by inhibiting DDA3-mediated Kif2a recruitment to the spindle.
    Title: DDA3 and Mdp3 modulate Kif2a recruitment onto the mitotic spindle to control minus-end spindle dynamics.
  6. these data indicate that ASB7 plays a crucial role in regulating spindle dynamics and genome integrity by controlling the expression of DDA3.
    Title: ASB7 regulates spindle dynamics and genome integrity by targeting DDA3 for proteasomal degradation.
  7. no association was found between the SNPs of rs599839, rs464218 and rs6698843 at the CELSR2-PSRC1-SORT1 and the risk of coronary artery disease or ischemic stroke
    Title: Association of variants in CELSR2-PSRC1-SORT1 with risk of serum lipid traits, coronary artery disease and ischemic stroke.
  8. Thus, ANKRD53 is recruited to the mitotic spindle by DDA3 and acts as a regulator of spindle dynamics and cytokinesis.
    Title: ANKRD53 interacts with DDA3 and regulates chromosome integrity during mitosis.
  9. Thus, our findings identified a definite regulatory mechanism of the search and capture process for stable spindle attachment through cross-talk between spindle dynamics and KT composition mediated by DDA3 and Ska1.
    Title: Ska1 cooperates with DDA3 for spindle dynamics and spindle attachment to kinetochore.
  10. DDA3 controls astral spindle formation and spindle positioning by targeting Cep290 to the centrosome. Depletion of Cep290 caused a reduction of the astral spindle, leading to misorientation of the mitotic spindle.
    Title: DDA3 targets Cep290 into the centrosome to regulate spindle positioning.
Submit: New GeneRIF Correction See all GeneRIFs (27)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease.
EBI GWAS Catalog
Biological, clinical and population relevance of 95 loci for blood lipids.
EBI GWAS Catalog
Common variants at 30 loci contribute to polygenic dyslipidemia.
EBI GWAS Catalog
Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis.
EBI GWAS Catalog
Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.
EBI GWAS Catalog
Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants.
EBI GWAS Catalog
Genome-wide association of lipid-lowering response to statins in combined study populations.
EBI GWAS Catalog
Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia.
EBI GWAS Catalog
Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.
EBI GWAS Catalog
Genome-wide association study of Lp-PLA(2) activity and mass in the Framingham Heart Study.
EBI GWAS Catalog
Genome-wide screen identifies rs646776 near sortilin as a regulator of progranulin levels in human plasma.
EBI GWAS Catalog
Genomewide association analysis of coronary artery disease.
EBI GWAS Catalog
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.
EBI GWAS Catalog
Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits.
EBI GWAS Catalog
LDL-cholesterol concentrations: a genome-wide association study.
EBI GWAS Catalog
Newly identified loci that influence lipid concentrations and risk of coronary artery disease.
EBI GWAS Catalog
Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants.
EBI GWAS Catalog
Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC1780

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in microtubule bundle formation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in mitotic metaphase chromosome alignment IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic metaphase chromosome alignment IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of cell growth ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in positive regulation of cyclin-dependent protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in positive regulation of microtubule polymerization ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in regulation of mitotic spindle organization IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule cytoskeleton ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in midbody ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in spindle ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
colocalizes_with spindle microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
colocalizes_with spindle microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with spindle pole IBA
Inferred from Biological aspect of Ancestor
more info
  
colocalizes_with spindle pole IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
proline/serine-rich coiled-coil protein 1
Names
differential display and activated by p53
p53-regulated DDA3
proline/serine-rich coiled-coil 1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005290.4 → NP_001005290.1  proline/serine-rich coiled-coil protein 1 isoform b

    See identical proteins and their annotated locations for NP_001005290.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses two different alternate splice sites, which results in a frameshift, compared to variant 1. It encodes isoform b which has a shorter and distinct C-terminus, compared to isoform a.
    Source sequence(s)
    BJ992594, BX649139
    Consensus CDS
    CCDS30791.1
    UniProtKB/Swiss-Prot
    Q6PGN9
    Related
    ENSP00000358920.3, ENST00000369904.7
    Conserved Domains (1) summary
    pfam15259
    Location:8 → 122
    GTSE1_N; G-2 and S-phase expressed 1

  2. NM_001032291.3 → NP_001027462.1  proline/serine-rich coiled-coil protein 1 isoform a

    See identical proteins and their annotated locations for NP_001027462.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Both variants 1 and 3 encode the same isoform (a).
    Source sequence(s)
    AK289593, AL390252, BI857497, BJ992594
    Consensus CDS
    CCDS797.1
    UniProtKB/TrEMBL
    A8K0M8
    Related
    ENSP00000358925.2, ENST00000369909.7
    Conserved Domains (2) summary
    PRK07003
    Location:98 → 333
    PRK07003; DNA polymerase III subunit gamma/tau
    pfam15259
    Location:8 → 122
    GTSE1_N; G-2 and S-phase expressed 1

  3. NM_001350237.2 → NP_001337166.1  proline/serine-rich coiled-coil protein 1 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and uses two alternate splice sites in the central coding region, but maintains the reading frame, compared to variant 1. It encodes isoform d which has the same N- and C-termini, but is shorter than isoform a. Variant 5-10 encode the same isoform (d).
    Source sequence(s)
    AL390252, AW898470, BX649139, DA141210, DA666480
    UniProtKB/TrEMBL
    A8K0M8
    Conserved Domains (2) summary
    pfam15259
    Location:8 → 122
    GTSE1_N; G-2 and S-phase expressed 1
    cl26464
    Location:47 → 317
    Atrophin-1; Atrophin-1 family

  4. NM_001350238.2 → NP_001337167.1  proline/serine-rich coiled-coil protein 1 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and uses two alternate splice sites in the central coding region, but maintains the reading frame, compared to variant 1. It encodes isoform d which has the same N- and C-termini, but is shorter than isoform a. Variant 5-10 encode the same isoform (d).
    Source sequence(s)
    AW898470, BJ992594, BX649139, DR158928
    UniProtKB/TrEMBL
    A8K0M8
    Conserved Domains (2) summary
    pfam15259
    Location:8 → 122
    GTSE1_N; G-2 and S-phase expressed 1
    cl26464
    Location:47 → 317
    Atrophin-1; Atrophin-1 family

  5. NM_001350239.2 → NP_001337168.1  proline/serine-rich coiled-coil protein 1 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and uses two alternate splice sites in the central coding region, but maintains the reading frame, compared to variant 1. It encodes isoform d which has the same N- and C-termini, but is shorter than isoform a. Variant 5-10 encode the same isoform (d).
    Source sequence(s)
    AW898470, BJ992594, BX649139, DR158928
    UniProtKB/TrEMBL
    A8K0M8
    Conserved Domains (2) summary
    pfam15259
    Location:8 → 122
    GTSE1_N; G-2 and S-phase expressed 1
    cl26464
    Location:47 → 317
    Atrophin-1; Atrophin-1 family

  6. NM_001350240.2 → NP_001337169.1  proline/serine-rich coiled-coil protein 1 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) uses two alternate splice sites in the central coding region, but maintains the reading frame, compared to variant 1. It encodes isoform d which has the same N- and C-termini, but is shorter than isoform a. Variant 5-10 encode the same isoform (d).
    Source sequence(s)
    AW898470, BP354477, BX649139, DR158928
    UniProtKB/TrEMBL
    A8K0M8
    Conserved Domains (2) summary
    pfam15259
    Location:8 → 122
    GTSE1_N; G-2 and S-phase expressed 1
    cl26464
    Location:47 → 317
    Atrophin-1; Atrophin-1 family

  7. NM_001350241.2 → NP_001337170.1  proline/serine-rich coiled-coil protein 1 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR and uses two alternate splice sites in the central coding region, but maintains the reading frame, compared to variant 1. It encodes isoform d which has the same N- and C-termini, but is shorter than isoform a. Variant 5-10 encode the same isoform (d).
    Source sequence(s)
    AW898470, BJ992594, BX649139, CN405809
    UniProtKB/TrEMBL
    A8K0M8
    Conserved Domains (2) summary
    pfam15259
    Location:8 → 122
    GTSE1_N; G-2 and S-phase expressed 1
    cl26464
    Location:47 → 317
    Atrophin-1; Atrophin-1 family

  8. NM_001350242.2 → NP_001337171.1  proline/serine-rich coiled-coil protein 1 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR and uses two alternate splice sites in the central coding region, but maintains the reading frame, compared to variant 1. It encodes isoform d which has the same N- and C-termini, but is shorter than isoform a. Variant 5-10 encode the same isoform (d).
    Source sequence(s)
    AW898470, BG281896, BJ992594, BX649139
    UniProtKB/TrEMBL
    A8K0M8
    Conserved Domains (2) summary
    pfam15259
    Location:8 → 122
    GTSE1_N; G-2 and S-phase expressed 1
    cl26464
    Location:47 → 317
    Atrophin-1; Atrophin-1 family

  9. NM_001363309.2 → NP_001350238.1  proline/serine-rich coiled-coil protein 1 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) differs in the 5' UTR and retains an intron in the 3' coding region compared to variant 1. It encodes isoform c which has the same N- and C-termini, as well as an additional segment, compared to isoform a
    Source sequence(s)
    BC056909, BI857497
    Consensus CDS
    CCDS30792.1
    UniProtKB/Swiss-Prot
    Q5T2Z3, Q6PGN9, Q6ZTI8, Q71MG3, Q9BV77
    UniProtKB/TrEMBL
    A8K0M8
    Related
    ENSP00000474667.1, ENST00000409138.6
    Conserved Domains (1) summary
    pfam15259
    Location:8 → 122
    GTSE1_N; G-2 and S-phase expressed 1

  10. NM_001394002.1 → NP_001380931.1  proline/serine-rich coiled-coil protein 1 isoform a

    Status: REVIEWED

    Source sequence(s)
    AL390252, KF459601
    Consensus CDS
    CCDS797.1
    UniProtKB/TrEMBL
    A8K0M8
    Conserved Domains (2) summary
    PRK07003
    Location:98 → 333
    PRK07003; DNA polymerase III subunit gamma/tau
    pfam15259
    Location:8 → 122
    GTSE1_N; G-2 and S-phase expressed 1

  11. NM_001394003.1 → NP_001380932.1  proline/serine-rich coiled-coil protein 1 isoform b

    Status: REVIEWED

    Source sequence(s)
    AL390252, KF459601
    Consensus CDS
    CCDS30791.1
    Conserved Domains (1) summary
    pfam15259
    Location:8 → 122
    GTSE1_N; G-2 and S-phase expressed 1

  12. NM_001394004.1 → NP_001380933.1  proline/serine-rich coiled-coil protein 1 isoform b

    Status: REVIEWED

    Source sequence(s)
    AL390252, KF459601
    Consensus CDS
    CCDS30791.1
    Conserved Domains (1) summary
    pfam15259
    Location:8 → 122
    GTSE1_N; G-2 and S-phase expressed 1

  13. NM_001394005.1 → NP_001380934.1  proline/serine-rich coiled-coil protein 1 isoform c

    Status: REVIEWED

    Source sequence(s)
    AL390252, KF459601
    Consensus CDS
    CCDS30792.1
    UniProtKB/Swiss-Prot
    Q5T2Z3, Q6PGN9, Q6ZTI8, Q71MG3, Q9BV77
    UniProtKB/TrEMBL
    A8K0M8
    Conserved Domains (1) summary
    pfam15259
    Location:8 → 122
    GTSE1_N; G-2 and S-phase expressed 1

  14. NM_032636.8 → NP_116025.1  proline/serine-rich coiled-coil protein 1 isoform a

    See identical proteins and their annotated locations for NP_116025.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the second-longest isoform (a). Both variants 1 and 3 encode the same isoform (a).
    Source sequence(s)
    AF223000, BI857497
    Consensus CDS
    CCDS797.1
    UniProtKB/TrEMBL
    A8K0M8
    Related
    ENSP00000358923.3, ENST00000369907.7
    Conserved Domains (2) summary
    PRK07003
    Location:98 → 333
    PRK07003; DNA polymerase III subunit gamma/tau
    pfam15259
    Location:8 → 122
    GTSE1_N; G-2 and S-phase expressed 1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    109279556..109283145 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005271283.4 → XP_005271340.1  proline/serine-rich coiled-coil protein 1 isoform X2

    See identical proteins and their annotated locations for XP_005271340.1

    UniProtKB/TrEMBL
    A8K0M8
    Conserved Domains (2) summary
    PRK07003
    Location:98 → 333
    PRK07003; DNA polymerase III subunit gamma/tau
    pfam15259
    Location:8 → 122
    GTSE1_N; G-2 and S-phase expressed 1

  2. XM_047432284.1 → XP_047288240.1  proline/serine-rich coiled-coil protein 1 isoform X4

  3. XM_047432275.1 → XP_047288231.1  proline/serine-rich coiled-coil protein 1 isoform X3

  4. XM_047432277.1 → XP_047288233.1  proline/serine-rich coiled-coil protein 1 isoform X4

  5. XM_017002564.2 → XP_016858053.1  proline/serine-rich coiled-coil protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q5T2Z3, Q6PGN9, Q6ZTI8, Q71MG3, Q9BV77
    UniProtKB/TrEMBL
    A8K0M8
    Conserved Domains (1) summary
    pfam15259
    Location:8 → 122
    GTSE1_N; G-2 and S-phase expressed 1

  6. XM_017002569.2 → XP_016858058.1  proline/serine-rich coiled-coil protein 1 isoform X2

    UniProtKB/TrEMBL
    A8K0M8
    Related
    ENSP00000358919.2, ENST00000369903.6
    Conserved Domains (2) summary
    PRK07003
    Location:98 → 333
    PRK07003; DNA polymerase III subunit gamma/tau
    pfam15259
    Location:8 → 122
    GTSE1_N; G-2 and S-phase expressed 1

  7. XM_047432274.1 → XP_047288230.1  proline/serine-rich coiled-coil protein 1 isoform X3

  8. XM_047432251.1 → XP_047288207.1  proline/serine-rich coiled-coil protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q5T2Z3, Q6PGN9, Q6ZTI8, Q71MG3, Q9BV77

  9. XM_017002560.3 → XP_016858049.1  proline/serine-rich coiled-coil protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q5T2Z3, Q6PGN9, Q6ZTI8, Q71MG3, Q9BV77
    UniProtKB/TrEMBL
    A8K0M8
    Conserved Domains (1) summary
    pfam15259
    Location:8 → 122
    GTSE1_N; G-2 and S-phase expressed 1

  10. XM_047432255.1 → XP_047288211.1  proline/serine-rich coiled-coil protein 1 isoform X2

  11. XM_017002562.2 → XP_016858051.1  proline/serine-rich coiled-coil protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q5T2Z3, Q6PGN9, Q6ZTI8, Q71MG3, Q9BV77
    UniProtKB/TrEMBL
    A8K0M8
    Conserved Domains (1) summary
    pfam15259
    Location:8 → 122
    GTSE1_N; G-2 and S-phase expressed 1

  12. XM_047432272.1 → XP_047288228.1  proline/serine-rich coiled-coil protein 1 isoform X2

    Related
    ENSP00000386323.1, ENST00000409267.5

  13. XM_017002567.2 → XP_016858056.1  proline/serine-rich coiled-coil protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q5T2Z3, Q6PGN9, Q6ZTI8, Q71MG3, Q9BV77
    UniProtKB/TrEMBL
    A8K0M8
    Conserved Domains (1) summary
    pfam15259
    Location:8 → 122
    GTSE1_N; G-2 and S-phase expressed 1

  14. XM_017002570.2 → XP_016858059.1  proline/serine-rich coiled-coil protein 1 isoform X2

    UniProtKB/TrEMBL
    A8K0M8
    Conserved Domains (2) summary
    PRK07003
    Location:98 → 333
    PRK07003; DNA polymerase III subunit gamma/tau
    pfam15259
    Location:8 → 122
    GTSE1_N; G-2 and S-phase expressed 1

  15. XM_047432294.1 → XP_047288250.1  proline/serine-rich coiled-coil protein 1 isoform X4

  16. XM_017002566.2 → XP_016858055.1  proline/serine-rich coiled-coil protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q5T2Z3, Q6PGN9, Q6ZTI8, Q71MG3, Q9BV77
    UniProtKB/TrEMBL
    A8K0M8
    Conserved Domains (1) summary
    pfam15259
    Location:8 → 122
    GTSE1_N; G-2 and S-phase expressed 1

  17. XM_047432264.1 → XP_047288220.1  proline/serine-rich coiled-coil protein 1 isoform X2

  18. XM_017002563.2 → XP_016858052.1  proline/serine-rich coiled-coil protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q5T2Z3, Q6PGN9, Q6ZTI8, Q71MG3, Q9BV77
    UniProtKB/TrEMBL
    A8K0M8
    Conserved Domains (1) summary
    pfam15259
    Location:8 → 122
    GTSE1_N; G-2 and S-phase expressed 1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    109312356..109315945 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054339232.1 → XP_054195207.1  proline/serine-rich coiled-coil protein 1 isoform X2

  2. XM_054339238.1 → XP_054195213.1  proline/serine-rich coiled-coil protein 1 isoform X4

  3. XM_054339236.1 → XP_054195211.1  proline/serine-rich coiled-coil protein 1 isoform X3

  4. XM_054339237.1 → XP_054195212.1  proline/serine-rich coiled-coil protein 1 isoform X4

  5. XM_054339223.1 → XP_054195198.1  proline/serine-rich coiled-coil protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q5T2Z3, Q6PGN9, Q6ZTI8, Q71MG3, Q9BV77

  6. XM_054339230.1 → XP_054195205.1  proline/serine-rich coiled-coil protein 1 isoform X2

  7. XM_054339235.1 → XP_054195210.1  proline/serine-rich coiled-coil protein 1 isoform X3

  8. XM_054339228.1 → XP_054195203.1  proline/serine-rich coiled-coil protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q5T2Z3, Q6PGN9, Q6ZTI8, Q71MG3, Q9BV77

  9. XM_054339222.1 → XP_054195197.1  proline/serine-rich coiled-coil protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q5T2Z3, Q6PGN9, Q6ZTI8, Q71MG3, Q9BV77

  10. XM_054339229.1 → XP_054195204.1  proline/serine-rich coiled-coil protein 1 isoform X2

  11. XM_054339224.1 → XP_054195199.1  proline/serine-rich coiled-coil protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q5T2Z3, Q6PGN9, Q6ZTI8, Q71MG3, Q9BV77

  12. XM_054339234.1 → XP_054195209.1  proline/serine-rich coiled-coil protein 1 isoform X2

  13. XM_054339227.1 → XP_054195202.1  proline/serine-rich coiled-coil protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q5T2Z3, Q6PGN9, Q6ZTI8, Q71MG3, Q9BV77

  14. XM_054339233.1 → XP_054195208.1  proline/serine-rich coiled-coil protein 1 isoform X2

  15. XM_054339239.1 → XP_054195214.1  proline/serine-rich coiled-coil protein 1 isoform X4

  16. XM_054339225.1 → XP_054195200.1  proline/serine-rich coiled-coil protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q5T2Z3, Q6PGN9, Q6ZTI8, Q71MG3, Q9BV77

  17. XM_054339231.1 → XP_054195206.1  proline/serine-rich coiled-coil protein 1 isoform X2

  18. XM_054339226.1 → XP_054195201.1  proline/serine-rich coiled-coil protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q5T2Z3, Q6PGN9, Q6ZTI8, Q71MG3, Q9BV77

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001032290.1: Suppressed sequence

    Description
    NM_001032290.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PGN9.1 GenPept UniProtKB/Swiss-Prot:Q6PGN9

Gene LinkOut

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Chemical Information
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