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Fen1 flap structure-specific endonuclease 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 84490, updated on 17-Aug-2024

Summary

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Official Symbol
Fen1provided by RGD
Official Full Name
flap structure-specific endonuclease 1provided by RGD
Primary source
RGD:621821
See related
EnsemblRapid:ENSRNOG00000020531 AllianceGenome:RGD:621821
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
FEN-1
Summary
Predicted to enable DNA binding activity; metal ion binding activity; and nuclease activity. Involved in memory. Located in nucleus. Orthologous to human FEN1 (flap structure-specific endonuclease 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 101.0), Spleen (RPKM 76.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Fen1 in Genome Data Viewer
Location:
1q43
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (216270016..216274873, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (206845126..206849821, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (226251516..226256160, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene S-formylglutathione hydrolase-like Neighboring gene fatty acid desaturase 1 Neighboring gene transmembrane protein 258 Neighboring gene myelin regulatory factor Neighboring gene diacylglycerol lipase, alpha

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification of flap structure-specific endonuclease 1 as a factor involved in long-term memory formation of aversive learning. Saavedra-Rodríguez L, et al. J Neurosci, 2009 May 6. PMID 19420241, Free PMC Article
  2. Gene expression of flap endonuclease-1 during cell proliferation and differentiation. Kim IS, et al. Biochim Biophys Acta, 2000 Apr 17. PMID 10771101
  3. Overexpression and hypomethylation of flap endonuclease 1 gene in breast and other cancers. Singh P, et al. Mol Cancer Res, 2008 Nov. PMID 19010819, Free PMC Article
  4. Fen1 mutations result in autoimmunity, chronic inflammation and cancers. Zheng L, et al. Nat Med, 2007 Jul. PMID 17589521
  5. Proliferation failure and gamma radiation sensitivity of Fen1 null mutant mice at the blastocyst stage. Larsen E, et al. Mol Cell Biol, 2003 Aug. PMID 12861020, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This study defines the fen-1 endonuclease as a new DNA recombination/repair factor involved in the formation of long-term memories.
    Title: Identification of flap structure-specific endonuclease 1 as a factor involved in long-term memory formation of aversive learning.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC94425

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 5'-3' exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 5'-3' exonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables 5'-flap endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 5'-flap endonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA-DNA hybrid ribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA-DNA hybrid ribonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables exonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables exonuclease activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables flap endonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables manganese ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables manganese ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA repair ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA replication, removal of RNA primer ISO
Inferred from Sequence Orthology
more info
  
involved_in base-excision repair IEA
Inferred from Electronic Annotation
more info
  
involved_in memory IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of sister chromatid cohesion ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
flap endonuclease 1
NP_001401385.1
NP_445882.2
XP_006231134.1
XP_006231136.1
XP_008758467.1
XP_063131907.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001414456.1 → NP_001401385.1  flap endonuclease 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    Q5XIP6, Q9JHW7

  2. NM_053430.3 → NP_445882.2  flap endonuclease 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    Q5XIP6, Q9JHW7
    Conserved Domains (1) summary
    PTZ00217
    Location:1 → 359
    PTZ00217; flap endonuclease-1; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    216270016..216274873 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006231072.5 → XP_006231134.1  flap endonuclease 1 isoform X1

    Related
    ENSRNOP00000081266.2, ENSRNOT00000104683.2
    Conserved Domains (3) summary
    cd09907
    Location:246 → 315
    H3TH_FEN1-Euk; H3TH domain of Flap Endonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease: Eukaryotic homologs
    cd09867
    Location:30 → 369
    PIN_FEN1; PIN domain of Flap Endonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease and homologs
    PTZ00217
    Location:26 → 384
    PTZ00217; flap endonuclease-1; Provisional

  2. XM_006231074.5 → XP_006231136.1  flap endonuclease 1 isoform X2

    See identical proteins and their annotated locations for XP_006231136.1

    UniProtKB/Swiss-Prot
    Q5XIP6, Q9JHW7
    Conserved Domains (1) summary
    PTZ00217
    Location:1 → 359
    PTZ00217; flap endonuclease-1; Provisional

  3. XM_063275837.1 → XP_063131907.1  flap endonuclease 1 isoform X2

    UniProtKB/Swiss-Prot
    Q5XIP6, Q9JHW7
    Related
    ENSRNOP00000078106.1, ENSRNOT00000106648.2

  4. XM_008760245.4 → XP_008758467.1  flap endonuclease 1 isoform X2

    See identical proteins and their annotated locations for XP_008758467.1

    UniProtKB/Swiss-Prot
    Q5XIP6, Q9JHW7
    Conserved Domains (1) summary
    PTZ00217
    Location:1 → 359
    PTZ00217; flap endonuclease-1; Provisional
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5XIP6.1 GenPept UniProtKB/Swiss-Prot:Q5XIP6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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