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Ilf3 interleukin enhancer binding factor 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 84472, updated on 2-Nov-2024

Summary

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Official Symbol
Ilf3provided by RGD
Official Full Name
interleukin enhancer binding factor 3provided by RGD
Primary source
RGD:619734
See related
EnsemblRapid:ENSRNOG00000022741 AllianceGenome:RGD:619734
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables enzyme binding activity. Acts upstream of or within protein methylation. Predicted to be located in mitochondrion; nucleolus; and nucleoplasm. Predicted to be part of ribonucleoprotein complex. Orthologous to human ILF3 (interleukin enhancer binding factor 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 115.1), Testes (RPKM 100.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ilf3 in Genome Data Viewer
Location:
8q13
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (28198454..28236634)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (19922409..19960495)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (22402877..22440984)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene adaptor related protein complex 1 subunit mu 2 Neighboring gene solute carrier family 44 member 2 Neighboring gene queuine tRNA-ribosyltransferase catalytic subunit 1 Neighboring gene dynamin 2 Neighboring gene uncharacterized LOC134480146

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Interleukin enhancement binding factor 3 inhibits cardiac hypertrophy by targeting asymmetric dimethylarginine-nitric oxide. Yang RH, et al. Nitric Oxide, 2019 Dec 1. PMID 31536826
  2. The interleukin-enhanced binding factor 3-mediated inhibition of nitric oxide production via phosphoinositide 3-kinase/protein kinase B pathway contributes to central cardiovascular regulation in the rostral ventrolateral medulla in hypertension. Tan X, et al. Am J Physiol Regul Integr Comp Physiol, 2022 Dec 1. PMID 36222883
  3. Long noncoding RNA ILF3-AS1 regulates myocardial infarction via the miR-212-3p/SIRT1 axis and PI3K/Akt signaling pathway. Zhang JY, et al. Eur Rev Med Pharmacol Sci, 2020 Mar. PMID 32196615
  4. Autoantibodies define a family of proteins with conserved double-stranded RNA-binding domains as well as DNA binding activity. Satoh M, et al. J Biol Chem, 1999 Dec 3. PMID 10574923
  5. Protein-arginine methyltransferase I, the predominant protein-arginine methyltransferase in cells, interacts with and is regulated by interleukin enhancer-binding factor 3. Tang J, et al. J Biol Chem, 2000 Jun 30. PMID 10749851

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The interleukin-enhanced binding factor 3-mediated inhibition of nitric oxide production via phosphoinositide 3-kinase/protein kinase B pathway contributes to central cardiovascular regulation in the rostral ventrolateral medulla in hypertension.
    Title: The interleukin-enhanced binding factor 3-mediated inhibition of nitric oxide production via phosphoinositide 3-kinase/protein kinase B pathway contributes to central cardiovascular regulation in the rostral ventrolateral medulla in hypertension.
  2. Long noncoding RNA ILF3-AS1 regulates myocardial infarction via the miR-212-3p/SIRT1 axis and PI3K/Akt signaling pathway.
    Title: Long noncoding RNA ILF3-AS1 regulates myocardial infarction via the miR-212-3p/SIRT1 axis and PI3K/Akt signaling pathway.
  3. ILF3 protein inhibits cardiac hypertrophy by targeting asymmetric dimethylarginine-nitric oxide. Its expression is regulated by angiotensin II.
    Title: Interleukin enhancement binding factor 3 inhibits cardiac hypertrophy by targeting asymmetric dimethylarginine-nitric oxide.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity TAS
Traceable Author Statement
more info
 PubMed 
enables double-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables double-stranded RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables double-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables enzyme binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables mRNA 3'-UTR AU-rich region binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA 3'-UTR AU-rich region binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA 3'-UTR AU-rich region binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables single-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables virus receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables virus receptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in defense response to virus IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of translation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of translation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of translation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of viral genome replication IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of viral genome replication ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of viral genome replication ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein methylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in spliceosome-depend formation of circular RNA IEA
Inferred from Electronic Annotation
more info
  
involved_in spliceosome-depend formation of circular RNA ISO
Inferred from Sequence Orthology
more info
  
involved_in spliceosome-depend formation of circular RNA ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in symbiont entry into host cell IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
interleukin enhancer-binding factor 3
Names
M phase phosphoprotein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053412.2 → NP_445864.2  interleukin enhancer-binding factor 3

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/Swiss-Prot
    Q9JIL3
    UniProtKB/TrEMBL
    A6JNR5
    Conserved Domains (3) summary
    smart00572
    Location:101 → 355
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    cd19910
    Location:411 → 483
    DSRM_ILF3_rpt1; first double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins
    cd19912
    Location:533 → 604
    DSRM_ILF3_rpt2; second double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    28198454..28236634
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063266245.1 → XP_063122315.1  interleukin enhancer-binding factor 3 isoform X9

  2. XM_008765994.4 → XP_008764216.1  interleukin enhancer-binding factor 3 isoform X6

    UniProtKB/Swiss-Prot
    Q9JIL3
    UniProtKB/TrEMBL
    A0A0G2K4U6
    Related
    ENSRNOP00000073179.2, ENSRNOT00000085320.3
    Conserved Domains (3) summary
    smart00572
    Location:88 → 342
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    cd19910
    Location:398 → 470
    DSRM_ILF3_rpt1; first double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins
    cd19912
    Location:520 → 591
    DSRM_ILF3_rpt2; second double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins

  3. XM_063266244.1 → XP_063122314.1  interleukin enhancer-binding factor 3 isoform X7

  4. XM_063266249.1 → XP_063122319.1  interleukin enhancer-binding factor 3 isoform X14

    UniProtKB/TrEMBL
    A0A8I6A0Y6

  5. XM_063266252.1 → XP_063122322.1  interleukin enhancer-binding factor 3 isoform X15

  6. XM_008765990.4 → XP_008764212.1  interleukin enhancer-binding factor 3 isoform X1

    UniProtKB/Swiss-Prot
    Q9JIL3
    Conserved Domains (3) summary
    smart00572
    Location:106 → 360
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    cd19910
    Location:416 → 488
    DSRM_ILF3_rpt1; first double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins
    cd19912
    Location:538 → 609
    DSRM_ILF3_rpt2; second double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins

  7. XM_039082213.2 → XP_038938141.1  interleukin enhancer-binding factor 3 isoform X8

    UniProtKB/Swiss-Prot
    Q9JIL3
    Conserved Domains (3) summary
    smart00572
    Location:106 → 360
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    cd19910
    Location:416 → 488
    DSRM_ILF3_rpt1; first double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins
    cd19912
    Location:538 → 609
    DSRM_ILF3_rpt2; second double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins

  8. XM_008765991.4 → XP_008764213.1  interleukin enhancer-binding factor 3 isoform X2

    UniProtKB/Swiss-Prot
    Q9JIL3
    Conserved Domains (2) summary
    smart00572
    Location:106 → 360
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    smart00358
    Location:420 → 484
    DSRM; Double-stranded RNA binding motif

  9. XM_008765995.4 → XP_008764217.1  interleukin enhancer-binding factor 3 isoform X10

    Conserved Domains (2) summary
    smart00572
    Location:106 → 360
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    smart00358
    Location:420 → 484
    DSRM; Double-stranded RNA binding motif

  10. XM_008765992.4 → XP_008764214.1  interleukin enhancer-binding factor 3 isoform X3

    See identical proteins and their annotated locations for XP_008764214.1

    UniProtKB/Swiss-Prot
    Q9JIL3
    UniProtKB/TrEMBL
    A6JNR5
    Conserved Domains (3) summary
    smart00572
    Location:101 → 355
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    cd19910
    Location:411 → 483
    DSRM_ILF3_rpt1; first double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins
    cd19912
    Location:533 → 604
    DSRM_ILF3_rpt2; second double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins

  11. XM_063266239.1 → XP_063122309.1  interleukin enhancer-binding factor 3 isoform X4

  12. XM_008765993.4 → XP_008764215.1  interleukin enhancer-binding factor 3 isoform X5

    UniProtKB/Swiss-Prot
    Q9JIL3
    UniProtKB/TrEMBL
    A0A0G2K2T6
    Related
    ENSRNOP00000072369.3, ENSRNOT00000079230.3
    Conserved Domains (3) summary
    smart00572
    Location:93 → 347
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    cd19910
    Location:403 → 475
    DSRM_ILF3_rpt1; first double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins
    cd19912
    Location:525 → 596
    DSRM_ILF3_rpt2; second double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins

  13. XM_008765996.4 → XP_008764218.1  interleukin enhancer-binding factor 3 isoform X12

    UniProtKB/TrEMBL
    F1LRU1
    Related
    ENSRNOP00000086301.2, ENSRNOT00000101953.2
    Conserved Domains (2) summary
    smart00572
    Location:101 → 355
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    smart00358
    Location:415 → 479
    DSRM; Double-stranded RNA binding motif

  14. XM_063266247.1 → XP_063122317.1  interleukin enhancer-binding factor 3 isoform X13

  15. XM_063266242.1 → XP_063122312.1  interleukin enhancer-binding factor 3 isoform X6

    UniProtKB/TrEMBL
    A0A0G2K4U6

  16. XM_017595942.3 → XP_017451431.1  interleukin enhancer-binding factor 3 isoform X1

    UniProtKB/Swiss-Prot
    Q9JIL3
    Conserved Domains (3) summary
    smart00572
    Location:106 → 360
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    cd19910
    Location:416 → 488
    DSRM_ILF3_rpt1; first double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins
    cd19912
    Location:538 → 609
    DSRM_ILF3_rpt2; second double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins

  17. XM_063266238.1 → XP_063122308.1  interleukin enhancer-binding factor 3 isoform X3

    UniProtKB/TrEMBL
    A6JNR5

  18. XM_039082212.2 → XP_038938140.1  interleukin enhancer-binding factor 3 isoform X6

    UniProtKB/Swiss-Prot
    Q9JIL3
    UniProtKB/TrEMBL
    A0A0G2K4U6
    Conserved Domains (3) summary
    smart00572
    Location:88 → 342
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    cd19910
    Location:398 → 470
    DSRM_ILF3_rpt1; first double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins
    cd19912
    Location:520 → 591
    DSRM_ILF3_rpt2; second double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins

  19. XM_063266250.1 → XP_063122320.1  interleukin enhancer-binding factor 3 isoform X14

    UniProtKB/TrEMBL
    A0A8I6A0Y6

  20. XM_063266248.1 → XP_063122318.1  interleukin enhancer-binding factor 3 isoform X13

  21. XM_063266241.1 → XP_063122311.1  interleukin enhancer-binding factor 3 isoform X6

    UniProtKB/TrEMBL
    A0A0G2K4U6

  22. XM_039082210.2 → XP_038938138.1  interleukin enhancer-binding factor 3 isoform X1

    UniProtKB/Swiss-Prot
    Q9JIL3
    Conserved Domains (3) summary
    smart00572
    Location:106 → 360
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    cd19910
    Location:416 → 488
    DSRM_ILF3_rpt1; first double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins
    cd19912
    Location:538 → 609
    DSRM_ILF3_rpt2; second double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins

  23. XM_063266240.1 → XP_063122310.1  interleukin enhancer-binding factor 3 isoform X5

    UniProtKB/TrEMBL
    A0A0G2K2T6

  24. XM_063266246.1 → XP_063122316.1  interleukin enhancer-binding factor 3 isoform X11

  25. XM_039082216.2 → XP_038938144.1  interleukin enhancer-binding factor 3 isoform X16

    Conserved Domains (2) summary
    cd19910
    Location:63 → 135
    DSRM_ILF3_rpt1; first double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins
    cd19912
    Location:185 → 256
    DSRM_ILF3_rpt2; second double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JIL3.2 GenPept UniProtKB/Swiss-Prot:Q9JIL3

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