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FAB1 fatty acid biosynthesis 1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 843835, updated on 18-Sep-2024

Summary

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Official Symbol
FAB1
Official Full Name
fatty acid biosynthesis 1
Primary source
TAIR:AT1G74960
Locus tag
AT1G74960
See related
Araport:AT1G74960
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ARABIDOPSIS BETA-KETOACYL-ACP SYNTHETASE 2; ATKAS2; BETA-KETOACYL-ACP SYNTHETASE 2; F25A4.7; F25A4_7; fatty acid biosynthesis 1; KAS2
Summary
Encodes a plastidic beta-ketoacyl-ACP synthase II, involved in fatty acid elongation from 16:0-ACP to 18:0-ACP. Homozygous knock-out mutants are embryo lethal, indicating early embryo development is sensitive to elevated 16:0.
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Genomic context

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See FAB1 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
14
Sequence:
Chromosome: 1; NC_003070.9 (28151920..28156350, complement)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene cyclin-dependent kinase, putative (DUF581) Neighboring gene TIFY domain/Divergent CCT motif family protein Neighboring gene ribosomal protein S9 Neighboring gene RING/U-box superfamily protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mutations in the Prokaryotic Pathway Rescue the fatty acid biosynthesis1 Mutant in the Cold. Gao J, et al. Plant Physiol, 2015 Sep. PMID 26224803, Free PMC Article
  2. Expression and developmental function of the 3-ketoacyl-ACP synthase2 gene in Arabidopsis thaliana. Hakozaki H, et al. Genes Genet Syst, 2008 Apr. PMID 18506098
  3. A KAS2 cDNA complements the phenotypes of the Arabidopsis fab1 mutant that differs in a single residue bordering the substrate binding pocket. Carlsson AS, et al. Plant J, 2002 Mar. PMID 12148534
  4. A mutation in the LPAT1 gene suppresses the sensitivity of fab1 plants to low temperature. Kim HU, et al. Plant Physiol, 2010 Jul. PMID 20488893, Free PMC Article
  5. A suppressor of fab1 challenges hypotheses on the role of thylakoid unsaturation in photosynthetic function. Barkan L, et al. Plant Physiol, 2006 Jul. PMID 16698898, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the identification of two suppressor mutations, one in act1, which encodes the chloroplast acyl-ACP:glycerol-3-phosphate acyltransferase, and one in lpat1, which encodes the chloroplast acyl-ACP:lysophosphatidic acid acyltransferase, is reported..
    Title: Mutations in the Prokaryotic Pathway Rescue the fatty acid biosynthesis1 Mutant in the Cold.
  2. The suppressor mutation of fab1 was identified, by map-based and candidate-gene approaches, as a hypomorphic allele of lysophosphatidic acid acyltransferase1 (lpat1), lpat1-3.
    Title: A mutation in the LPAT1 gene suppresses the sensitivity of fab1 plants to low temperature.
  3. Results suggest that AtKAS2 is required for embryo development in Arabidopsis during the transition from the globular to the heart stage.
    Title: Expression and developmental function of the 3-ketoacyl-ACP synthase2 gene in Arabidopsis thaliana.
  4. A change in shape of the major thylakoid lipid, monogalactosyldiacylglycerol, mediated by the fad5-2 mutation, may compensate for changes in lipid structure resulting from the original fab1 mutation.
    Title: A suppressor of fab1 challenges hypotheses on the role of thylakoid unsaturation in photosynthetic function.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001198471.1
NM_106154.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables 3-oxoacyl-[acyl-carrier-protein] synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 3-oxoacyl-[acyl-carrier-protein] synthase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in cold acclimation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in embryo development ending in seed dormancy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within fatty acid biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within unsaturated fatty acid biosynthetic process TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast HDA PubMed 
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in chloroplast stroma HDA PubMed 
located_in cytosol HDA PubMed 
located_in plastid ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
fatty acid biosynthesis 1
NP_001185400.1
  • fatty acid biosynthesis 1 (FAB1); CONTAINS InterPro DOMAIN/s: Beta-ketoacyl synthase (InterPro:IPR000794), Thiolase-like (InterPro:IPR016039), Beta-ketoacyl synthase, C-terminal (InterPro:IPR014031), 3-oxoacyl-[acyl-carrier-protein] synthase 2 (InterPro:IPR017568), Beta-ketoacyl synthase, N-terminal (InterPro:IPR014030), Thiolase-like, subgroup (InterPro:IPR016038), Beta-ketoacyl synthase, active site (InterPro:IPR018201); BEST Arabidopsis thaliana protein match is: 3-ketoacyl-acyl carrier protein synthase I (TAIR:AT5G46290.1).
NP_565097.1
  • fatty acid biosynthesis 1 (FAB1); FUNCTIONS IN: 3-oxoacyl-[acyl-carrier-protein] synthase activity, fatty acid synthase activity; INVOLVED IN: fatty acid biosynthetic process, unsaturated fatty acid biosynthetic process; LOCATED IN: chloroplast, plastid; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Beta-ketoacyl synthase (InterPro:IPR000794), Thiolase-like (InterPro:IPR016039), Beta-ketoacyl synthase, C-terminal (InterPro:IPR014031), 3-oxoacyl-[acyl-carrier-protein] synthase 2 (InterPro:IPR017568), Beta-ketoacyl synthase, N-terminal (InterPro:IPR014030), Thiolase-like, subgroup (InterPro:IPR016038), Beta-ketoacyl synthase, active site (InterPro:IPR018201); BEST Arabidopsis thaliana protein match is: 3-ketoacyl-acyl carrier protein synthase I (TAIR:AT5G46290.1); Has 31012 Blast hits to 28002 proteins in 3663 species: Archae - 7; Bacteria - 21780; Metazoa - 495; Fungi - 2498; Plants - 402; Viruses - 1; Other Eukaryotes - 5829 (source: NCBI BLink).
NP_849888.1
  • fatty acid biosynthesis 1 (FAB1); FUNCTIONS IN: 3-oxoacyl-[acyl-carrier-protein] synthase activity, fatty acid synthase activity; INVOLVED IN: fatty acid biosynthetic process, unsaturated fatty acid biosynthetic process; LOCATED IN: chloroplast, plastid; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Beta-ketoacyl synthase (InterPro:IPR000794), Thiolase-like (InterPro:IPR016039), Beta-ketoacyl synthase, C-terminal (InterPro:IPR014031), 3-oxoacyl-[acyl-carrier-protein] synthase 2 (InterPro:IPR017568), Beta-ketoacyl synthase, N-terminal (InterPro:IPR014030), Thiolase-like, subgroup (InterPro:IPR016038), Beta-ketoacyl synthase, active site (InterPro:IPR018201); BEST Arabidopsis thaliana protein match is: 3-ketoacyl-acyl carrier protein synthase I (TAIR:AT5G46290.1); Has 31012 Blast hits to 28002 proteins in 3663 species: Archae - 7; Bacteria - 21780; Metazoa - 495; Fungi - 2498; Plants - 402; Viruses - 1; Other Eukaryotes - 5829 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    28151920..28156350 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_179557.4 → NP_849888.1  fatty acid biosynthesis 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_849888.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8RXF5, Q945N5, Q9C9P4, Q9SSG8
    UniProtKB/TrEMBL
    A0A5S9WUI4, A0A654EQM7
    Conserved Domains (1) summary
    PLN02787
    Location:3 → 541
    PLN02787; 3-oxoacyl-[acyl-carrier-protein] synthase II

  2. NM_001198471.1 → NP_001185400.1  fatty acid biosynthesis 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001185400.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8RXF5, Q945N5, Q9C9P4, Q9SSG8
    UniProtKB/TrEMBL
    A0A5S9WUI4, A0A654EQM7
    Conserved Domains (1) summary
    PLN02787
    Location:3 → 541
    PLN02787; 3-oxoacyl-[acyl-carrier-protein] synthase II

  3. NM_106154.4 → NP_565097.1  fatty acid biosynthesis 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_565097.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8RXF5, Q945N5, Q9C9P4, Q9SSG8
    UniProtKB/TrEMBL
    A0A5S9WUI4, A0A654EQM7
    Conserved Domains (1) summary
    PLN02787
    Location:3 → 541
    PLN02787; 3-oxoacyl-[acyl-carrier-protein] synthase II
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9C9P4.1

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