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FAB1C FORMS APLOID AND BINUCLEATE CELLS 1C [ Arabidopsis thaliana (thale cress) ]

Gene ID: 843440, updated on 18-Sep-2024

Summary

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Official Symbol
FAB1C
Official Full Name
FORMS APLOID AND BINUCLEATE CELLS 1C
Primary source
TAIR:AT1G71010
Locus tag
AT1G71010
See related
Araport:AT1G71010
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
F23N20.21; FORMS APLOID AND BINUCLEATE CELLS 1C
Summary
Encodes a protein that is predicted to act as a phosphatidylinositol-3P 5-kinase, but, because it lacks a FYVE domain, it is unlikely to be efficiently targeted to membranes containing the proposed phosphatidylinositol-3P substrate. Therefore, its molecular function remains unknown.
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Genomic context

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See FAB1C in Genome Data Viewer
Location:
chromosome: 1
Exon count:
11
Sequence:
Chromosome: 1; NC_003070.9 (26782048..26788973)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene plastid movement impaired protein Neighboring gene ARM repeat superfamily protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. FAB1C, a phosphatidylinositol 3-phosphate 5-kinase, interacts with PIN-FORMEDs and modulates their lytic trafficking in Arabidopsis. Maeng KH, et al. Proc Natl Acad Sci U S A, 2023 Nov 14. PMID 37934824, Free PMC Article
  2. Rapid structural changes and acidification of guard cell vacuoles during stomatal closure require phosphatidylinositol 3,5-bisphosphate. Bak G, et al. Plant Cell, 2013 Jun. PMID 23757398, Free PMC Article
  3. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FAB1C, a phosphatidylinositol 3-phosphate 5-kinase, interacts with PIN-FORMEDs and modulates their lytic trafficking in Arabidopsis.
    Title: FAB1C, a phosphatidylinositol 3-phosphate 5-kinase, interacts with PIN-FORMEDs and modulates their lytic trafficking in Arabidopsis.
  2. Data indicate that single and double mutants of phosphatidylinositol 3-phosphate 5-kinases (PI3P5Ks) FAB1A, FAB1B, FAB1C and FAB1D exhibited slow stomatal closure upon ABA treatment.
    Title: Rapid structural changes and acidification of guard cell vacuoles during stomatal closure require phosphatidylinositol 3,5-bisphosphate.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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NM_105770.6

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables 1-phosphatidylinositol-3-phosphate 5-kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in phosphatidylinositol metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within stomatal closure IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
FORMS APLOID AND BINUCLEATE CELLS 1C
NP_177257.3
  • FORMS APLOID AND BINUCLEATE CELLS 1C (FAB1C); FUNCTIONS IN: 1-phosphatidylinositol-4-phosphate 5-kinase activity, phosphatidylinositol phosphate kinase activity, ATP binding; INVOLVED IN: phosphatidylinositol metabolic process, cellular protein metabolic process; LOCATED IN: cellular_component unknown; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Chaperonin Cpn60/TCP-1 (InterPro:IPR002423), Phosphatidylinositol-4-phosphate 5-kinase, core (InterPro:IPR002498); BEST Arabidopsis thaliana protein match is: phosphatidylinositol-4-phosphate 5-kinase family protein (TAIR:AT3G14270.1); Has 4961 Blast hits to 4644 proteins in 430 species: Archae - 584; Bacteria - 4; Metazoa - 1658; Fungi - 1043; Plants - 685; Viruses - 0; Other Eukaryotes - 987 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    26782048..26788973
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_105770.6 → NP_177257.3  FORMS APLOID AND BINUCLEATE CELLS 1C [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_177257.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8VZ86, Q9SSJ8
    UniProtKB/TrEMBL
    A0A178WPD0
    Conserved Domains (2) summary
    cd03334
    Location:330 → 602
    Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
    cl02572
    Location:1370 → 1640
    PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9SSJ8.1

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