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EIF1AD eukaryotic translation initiation factor 1A domain containing [ Homo sapiens (human) ]

Gene ID: 84285, updated on 2-Nov-2024

Summary

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Official Symbol
EIF1ADprovided by HGNC
Official Full Name
eukaryotic translation initiation factor 1A domain containingprovided by HGNC
Primary source
HGNC:HGNC:28147
See related
Ensembl:ENSG00000175376 MIM:618473; AllianceGenome:HGNC:28147
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OBELIX; haponin
Summary
Predicted to enable RNA binding activity and translation initiation factor activity. Predicted to be involved in translational initiation. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in bone marrow (RPKM 7.6), testis (RPKM 6.0) and 25 other tissues See more
Orthologs
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Genomic context

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See EIF1AD in Genome Data Viewer
Location:
11q13.1
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (65996545..66002157, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (65990678..65996291, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (65764016..65769628, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:65729063-65729850 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:65733572-65734072 Neighboring gene spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP Neighboring gene phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5024 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:65767725-65768224 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5025 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3569 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:65770703-65771509 Neighboring gene Sharpr-MPRA regulatory region 5067 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:65775781-65776575 Neighboring gene barrier to autointegration nuclear assembly factor 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:65780961-65781536 Neighboring gene cystatin E/M Neighboring gene cation channel sperm associated 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:65790121-65790622

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Novel protein haponin regulates cellular response to oxidative stress.
    Title: Novel protein haponin regulates cellular response to oxidative stress.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC11102

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables translation initiation factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in translational initiation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
probable RNA-binding protein EIF1AD
Names
eukaryotic translation initiation factor 1A domain-containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001242481.2 → NP_001229410.1  probable RNA-binding protein EIF1AD

    See identical proteins and their annotated locations for NP_001229410.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript.
    Source sequence(s)
    AI831454, AP006287, BE669813, BE791453, BP328412
    Consensus CDS
    CCDS8124.1
    UniProtKB/Swiss-Prot
    B2R4N5, Q8N9N8, Q9BSC1
    Related
    ENSP00000434056.1, ENST00000533544.6
    Conserved Domains (1) summary
    cd05792
    Location:25 → 102
    S1_eIF1AD_like; eukaryotic translation initiation factor 1A domain containing protein (eIF1AD)-like, S1-like RNA-binding domain. eIF1AD is also known as MGC11102 protein. Little is known about the function of eIF1AD. S1-like RNA-binding domains are found in a wide ...

  2. NM_001242482.2 → NP_001229411.1  probable RNA-binding protein EIF1AD

    See identical proteins and their annotated locations for NP_001229411.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1, but encodes the same protein.
    Source sequence(s)
    AP006287, BE669813, BE791453, BP328412, BU790195
    Consensus CDS
    CCDS8124.1
    UniProtKB/Swiss-Prot
    B2R4N5, Q8N9N8, Q9BSC1
    Related
    ENSP00000435439.1, ENST00000527249.5
    Conserved Domains (1) summary
    cd05792
    Location:25 → 102
    S1_eIF1AD_like; eukaryotic translation initiation factor 1A domain containing protein (eIF1AD)-like, S1-like RNA-binding domain. eIF1AD is also known as MGC11102 protein. Little is known about the function of eIF1AD. S1-like RNA-binding domains are found in a wide ...

  3. NM_001242483.2 → NP_001229412.1  probable RNA-binding protein EIF1AD

    See identical proteins and their annotated locations for NP_001229412.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in the 5' UTR, compared to variant 1, but encodes the same protein.
    Source sequence(s)
    AP006287, AW872373, BE669813, BE791453, BP328412
    Consensus CDS
    CCDS8124.1
    UniProtKB/Swiss-Prot
    B2R4N5, Q8N9N8, Q9BSC1
    Conserved Domains (1) summary
    cd05792
    Location:25 → 102
    S1_eIF1AD_like; eukaryotic translation initiation factor 1A domain containing protein (eIF1AD)-like, S1-like RNA-binding domain. eIF1AD is also known as MGC11102 protein. Little is known about the function of eIF1AD. S1-like RNA-binding domains are found in a wide ...

  4. NM_001242484.2 → NP_001229413.1  probable RNA-binding protein EIF1AD

    See identical proteins and their annotated locations for NP_001229413.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site in the 5' UTR, compared to variant 1, but encodes the same protein.
    Source sequence(s)
    AP006287, BE669813, DA024526
    Consensus CDS
    CCDS8124.1
    UniProtKB/Swiss-Prot
    B2R4N5, Q8N9N8, Q9BSC1
    Conserved Domains (1) summary
    cd05792
    Location:25 → 102
    S1_eIF1AD_like; eukaryotic translation initiation factor 1A domain containing protein (eIF1AD)-like, S1-like RNA-binding domain. eIF1AD is also known as MGC11102 protein. Little is known about the function of eIF1AD. S1-like RNA-binding domains are found in a wide ...

  5. NM_001242485.2 → NP_001229414.1  probable RNA-binding protein EIF1AD

    See identical proteins and their annotated locations for NP_001229414.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) uses multiple alternate splice sites in the 5' UTR, compared to variant 1, but encodes the same protein.
    Source sequence(s)
    AP006287, BC005131, BG149615, BP328412
    Consensus CDS
    CCDS8124.1
    UniProtKB/Swiss-Prot
    B2R4N5, Q8N9N8, Q9BSC1
    Related
    ENSP00000436644.1, ENST00000526451.5
    Conserved Domains (1) summary
    cd05792
    Location:25 → 102
    S1_eIF1AD_like; eukaryotic translation initiation factor 1A domain containing protein (eIF1AD)-like, S1-like RNA-binding domain. eIF1AD is also known as MGC11102 protein. Little is known about the function of eIF1AD. S1-like RNA-binding domains are found in a wide ...

  6. NM_001242486.2 → NP_001229415.1  probable RNA-binding protein EIF1AD

    See identical proteins and their annotated locations for NP_001229415.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) uses multiple alternate splice sites in the 5' UTR, compared to variant 1, but encodes the same protein.
    Source sequence(s)
    AP006287, BP328412
    Consensus CDS
    CCDS8124.1
    UniProtKB/Swiss-Prot
    B2R4N5, Q8N9N8, Q9BSC1
    Related
    ENSP00000435942.2, ENST00000529964.5
    Conserved Domains (1) summary
    cd05792
    Location:25 → 102
    S1_eIF1AD_like; eukaryotic translation initiation factor 1A domain containing protein (eIF1AD)-like, S1-like RNA-binding domain. eIF1AD is also known as MGC11102 protein. Little is known about the function of eIF1AD. S1-like RNA-binding domains are found in a wide ...

  7. NM_032325.4 → NP_115701.2  probable RNA-binding protein EIF1AD

    See identical proteins and their annotated locations for NP_115701.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' UTR, compared to variant 1, but encodes the same protein.
    Source sequence(s)
    AK311891, AP006287, BP328412
    Consensus CDS
    CCDS8124.1
    UniProtKB/Swiss-Prot
    B2R4N5, Q8N9N8, Q9BSC1
    Related
    ENSP00000309175.2, ENST00000312234.6
    Conserved Domains (1) summary
    cd05792
    Location:25 → 102
    S1_eIF1AD_like; eukaryotic translation initiation factor 1A domain containing protein (eIF1AD)-like, S1-like RNA-binding domain. eIF1AD is also known as MGC11102 protein. Little is known about the function of eIF1AD. S1-like RNA-binding domains are found in a wide ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    65996545..66002157 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017018412.3 → XP_016873901.1  probable RNA-binding protein EIF1AD isoform X1

    UniProtKB/Swiss-Prot
    B2R4N5, Q8N9N8, Q9BSC1
    Conserved Domains (1) summary
    cd05792
    Location:25 → 102
    S1_eIF1AD_like; eukaryotic translation initiation factor 1A domain containing protein (eIF1AD)-like, S1-like RNA-binding domain. eIF1AD is also known as MGC11102 protein. Little is known about the function of eIF1AD. S1-like RNA-binding domains are found in a wide ...

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    65990678..65996291 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054370174.1 → XP_054226149.1  probable RNA-binding protein EIF1AD isoform X1

    UniProtKB/Swiss-Prot
    B2R4N5, Q8N9N8, Q9BSC1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N9N8.1 GenPept UniProtKB/Swiss-Prot:Q8N9N8

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