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NTPCR nucleoside-triphosphatase, cancer-related [ Homo sapiens (human) ]

Gene ID: 84284, updated on 14-Nov-2024

Summary

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Official Symbol
NTPCRprovided by HGNC
Official Full Name
nucleoside-triphosphatase, cancer-relatedprovided by HGNC
Primary source
HGNC:HGNC:28204
See related
Ensembl:ENSG00000135778 AllianceGenome:HGNC:28204
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
THEP1; C1orf57; HCR-NTPase
Summary
The protein encoded by this gene is a non-specific nucleoside triphosphatase that is slow-acting in vitro. This gene is overexpressed in many tumor tissues, and while it is not essential for the cell, overexpression is cytotoxic. However, the cytotoxicity is not related to its triphosphatase activity. [provided by RefSeq, Jul 2016]
Expression
Ubiquitous expression in brain (RPKM 18.5), kidney (RPKM 18.3) and 25 other tissues See more
Orthologs
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Genomic context

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See NTPCR in Genome Data Viewer
Location:
1q42.2
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (232950611..232983882)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (232336950..232370221)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (233086357..233119628)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101927711 Neighboring gene RNA, U1 small nuclear 74, pseudogene Neighboring gene uncharacterized LOC105373201 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2733 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:233059320-233060519 Neighboring gene uncharacterized LOC107985361 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:233086091-233086632 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:233086633-233087172 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:233088301-233088800 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:233113500-233114699 Neighboring gene pecanex 2 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:233215157-233215658 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:233215659-233216158 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:233250348-233251547 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:233264306-233264818 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:233264819-233265329 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:233314891-233316090 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:233370205-233370728 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:233370729-233371250 Neighboring gene Sharpr-MPRA regulatory region 15021 Neighboring gene MPRA-validated peak771 silencer Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:233393606-233394805 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2738 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2739 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2740 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:233422285-233422784 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:233421783-233422284 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2741 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1959 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1960 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:233463573-233463724 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1962 Neighboring gene ribosomal protein S7 pseudogene 3 Neighboring gene mitogen-activated protein kinase kinase kinase 21 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:233507364-233507864

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. On the cytotoxicity of HCR-NTPase in the neuroblastoma cell line SH-SY5Y. Pasdziernik M, et al. BMC Res Notes, 2009 Jun 11. PMID 19519914, Free PMC Article
  2. Progesterone induced Warburg effect in HEK293 cells is associated with post-translational modifications and proteasomal degradation of progesterone receptor membrane component 1. Sabbir MG. J Steroid Biochem Mol Biol, 2019 Jul. PMID 31067491
  3. NMR structure and functional characterization of a human cancer-related nucleoside triphosphatase. Placzek WJ, et al. J Mol Biol, 2007 Mar 30. PMID 17291528
  4. Engagement of the G3BP2-TRIM25 Interaction by Nucleocapsid Protein Suppresses the Type I Interferon Response in SARS-CoV-2-Infected Cells. Yang Z, et al. Vaccines (Basel), 2022 Nov 29. PMID 36560452, Free PMC Article
  5. Stabilization of the methyl-CpG binding protein ZBTB38 by the deubiquitinase USP9X limits the occurrence and toxicity of oxidative stress in human cells. Miotto B, et al. Nucleic Acids Res, 2018 May 18. PMID 29490077, Free PMC Article

See all (95) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ11383, MGC13186

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent H2AZ histone chaperone activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent H3-H4 histone complex chaperone activity IEA
Inferred from Electronic Annotation
more info
  
enables CTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA clamp loader activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding HDA PubMed 
enables chromatin extrusion motor activity IEA
Inferred from Electronic Annotation
more info
  
enables cohesin loader activity IEA
Inferred from Electronic Annotation
more info
  
enables membrane scission GTPase motor activity IEA
Inferred from Electronic Annotation
more info
  
enables ribonucleoside triphosphate phosphatase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin looping IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane HDA PubMed 
located_in mitochondrion HTP PubMed 

General protein information

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Preferred Names
cancer-related nucleoside-triphosphatase
Names
human cancer-related NTPase
nucleoside triphosphate phosphohydrolase
nucleoside-triphosphatase C1orf57
NP_001316381.1
NP_001316382.1
NP_115700.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001329452.2 → NP_001316381.1  cancer-related nucleoside-triphosphatase isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL122003, BQ001389

  2. NM_001329453.2 → NP_001316382.1  cancer-related nucleoside-triphosphatase isoform 3

    Status: REVIEWED

    Source sequence(s)
    AA635564, AL122003, BC005102, BQ001389, HY133356
    UniProtKB/Swiss-Prot
    Q9BSD7
    Conserved Domains (1) summary
    cl21455
    Location:4 → 102
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  3. NM_032324.3 → NP_115700.1  cancer-related nucleoside-triphosphatase isoform 1

    See identical proteins and their annotated locations for NP_115700.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL122003, BC005102, BQ001389, HY133356
    Consensus CDS
    CCDS1597.1
    UniProtKB/Swiss-Prot
    Q9BSD7
    UniProtKB/TrEMBL
    Q5TDE9
    Related
    ENSP00000355587.4, ENST00000366628.10
    Conserved Domains (1) summary
    pfam03266
    Location:4 → 182
    NTPase_1; NTPase

RNA

  1. NR_138024.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL122003, BC005102, BG106026, BQ001389, HY133356

  2. NR_138025.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL122003, BC005102, BF663221, BQ001389, HY133356

  3. NR_138026.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL122003, BC005102, BQ001389, HY133356, W80669

  4. NR_138027.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL122003, BC005102, BG473925, BQ001389

  5. NR_138028.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL122003, BC005102, BQ001389, DC332692, HY133356

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    232950611..232983882
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    232336950..232370221
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BSD7.1 GenPept UniProtKB/Swiss-Prot:Q9BSD7

Gene LinkOut

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