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Transducin/WD40 repeat-like superfamily protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 842811, updated on 18-Sep-2024

Summary

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Official Full Name
Transducin/WD40 repeat-like superfamily protein
Primary source
TAIR:AT1G65030
Locus tag
AT1G65030
See related
Araport:AT1G65030
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
F16G16.2; F16G16_2
Summary
This gene is predicted to encode a protein with a DWD motif. It can bind to DDB1a in Y2H assays, and DDB1b in co-IP assays, and may be involved in the formation of a CUL4-based E3 ubiquitin ligase
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Genomic context

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Location:
chromosome: 1
Exon count:
3
Sequence:
Chromosome: 1; NC_003070.9 (24156672..24158675)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene F-box only protein Neighboring gene WEB family protein (DUF827) Neighboring gene plasma protein Neighboring gene COMPLEX 1 LYR-like protein Neighboring gene RING/U-box superfamily protein Neighboring gene TRAF-like superfamily protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of Arabidopsis and rice DWD proteins and their roles as substrate receptors for CUL4-RING E3 ubiquitin ligases. Lee JH, et al. Plant Cell, 2008 Jan. PMID 18223036, Free PMC Article
  2. Proteomic analysis of the Arabidopsis nucleolus suggests novel nucleolar functions. Pendle AF, et al. Mol Biol Cell, 2005 Jan. PMID 15496452, Free PMC Article
  3. A Pan-plant Protein Complex Map Reveals Deep Conservation and Novel Assemblies. McWhite CD, et al. Cell, 2020 Apr 16. PMID 32191846, Free PMC Article
  4. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_105177.5

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of Cul4-RING E3 ubiquitin ligase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in nucleolus HDA PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
Transducin/WD40 repeat-like superfamily protein
NP_176683.1
  • Transducin/WD40 repeat-like superfamily protein; FUNCTIONS IN: protein binding, nucleotide binding; LOCATED IN: nucleolus, CUL4 RING ubiquitin ligase complex, heterotrimeric G-protein complex; EXPRESSED IN: cultured cell; CONTAINS InterPro DOMAIN/s: WD40 repeat 2 (InterPro:IPR019782), WD40 repeat-like-containing domain (InterPro:IPR011046), WD40 repeat, conserved site (InterPro:IPR019775), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), WD40 repeat (InterPro:IPR001680), WD40 repeat, subgroup (InterPro:IPR019781); Has 5965 Blast hits to 4406 proteins in 385 species: Archae - 22; Bacteria - 1754; Metazoa - 1570; Fungi - 1477; Plants - 405; Viruses - 0; Other Eukaryotes - 737 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    24156672..24158675
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_105177.5 → NP_176683.1  Transducin/WD40 repeat-like superfamily protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_176683.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178W155, Q5XEV4, Q8H177
    Conserved Domains (2) summary
    sd00039
    Location:45 → 81
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:39 → 319
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein
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