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DAL1 E3 Ubiquitin ligase family protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 842693, updated on 18-Sep-2024

Summary

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Official Symbol
DAL1
Official Full Name
E3 Ubiquitin ligase family protein
Primary source
TAIR:AT1G63900
Locus tag
AT1G63900
See related
Araport:AT1G63900
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
AT1G63890; DIAP1-like protein 1; SP1; SUPPRESSOR OF PPI1 locus 1; T12P18.8; T12P18_8
Summary
Encodes a RING-type ubiquitin E3 ligase of the chloroplast outer membrane that associates with TOC complexes and mediated ubiquitination of TOC components, promoting their degradation.
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Genomic context

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See DAL1 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
10
Sequence:
Chromosome: 1; NC_003070.9 (23716643..23719337)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Disease resistance protein (TIR-NBS-LRR class) family Neighboring gene Disease resistance protein (TIR-NBS-LRR class) family Neighboring gene myb domain protein 103 Neighboring gene miscRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. MORF2 tightly associates with MORF9 to regulate chloroplast RNA editing in Arabidopsis. Huang C, et al. Plant Sci, 2019 Jan. PMID 30471730
  2. E3 ubiquitin ligase SP1 regulates peroxisome biogenesis in Arabidopsis. Pan R, et al. Proc Natl Acad Sci U S A, 2016 Nov 15. PMID 27799549, Free PMC Article
  3. Chloroplast biogenesis is regulated by direct action of the ubiquitin-proteasome system. Ling Q, et al. Science, 2012 Nov 2. PMID 23118188
  4. Border control--a membrane-linked interactome of Arabidopsis. Jones AM, et al. Science, 2014 May 16. PMID 24833385
  5. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MORF2-MORF9 heterodimer is a core member of editosomes in Arabidopsis chloroplasts. [MORF2]
    Title: MORF2 tightly associates with MORF9 to regulate chloroplast RNA editing in Arabidopsis.
  2. In this study, we identified the Arabidopsis RING-type E3 ubiquitin ligase SP1 as a peroxisome membrane protein that regulates peroxisome biogenesis.
    Title: E3 ubiquitin ligase SP1 regulates peroxisome biogenesis in Arabidopsis.
  3. SP1 protein (At1g63900) associated with TOC (translocon at the outer envelope of chloroplasts) complexes and mediated ubiquitination of TOC components, promoting degradation; mutant sp1 plants performed developmental transitions involving plastid proteome changes inefficiently, indicating requirement for reorganization of TOC machinery
    Title: Chloroplast biogenesis is regulated by direct action of the ubiquitin-proteasome system.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_105064.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within chloroplast organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within negative regulation of fatty acid beta-oxidation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within negative regulation of fatty acid beta-oxidation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in organelle organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein destabilization IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within protein import into chloroplast stroma IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within protein import into peroxisome matrix IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within protein ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of protein import into chloroplast stroma IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chloroplast envelope IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chloroplast outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISM
Inferred from Sequence Model
more info
  
located_in peroxisomal membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
E3 Ubiquitin ligase family protein
NP_001319312.1
  • E3 Ubiquitin ligase family protein; FUNCTIONS IN: zinc ion binding; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Zinc finger, RING-type (InterPro:IPR001841), E3 Ubiquitin ligase (InterPro:IPR022170); BEST Arabidopsis thaliana protein match is: E3 Ubiquitin ligase family protein (TAIR:AT1G59560.1).
NP_176574.2
  • E3 Ubiquitin ligase family protein; FUNCTIONS IN: zinc ion binding; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Zinc finger, RING-type (InterPro:IPR001841), E3 Ubiquitin ligase (InterPro:IPR022170); BEST Arabidopsis thaliana protein match is: E3 Ubiquitin ligase family protein (TAIR:AT1G59560.1); Has 3444 Blast hits to 3338 proteins in 260 species: Archae - 0; Bacteria - 10; Metazoa - 1891; Fungi - 50; Plants - 799; Viruses - 222; Other Eukaryotes - 472 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    23716643..23719337
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001334139.1 → NP_001319312.1  E3 Ubiquitin ligase family protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    F4I570

  2. NM_105064.4 → NP_176574.2  E3 Ubiquitin ligase family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_176574.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8L7N4, Q9CAK2, Q9CAK3
    UniProtKB/TrEMBL
    A0A178WJL1, A0A5S9WS89
    Conserved Domains (2) summary
    cd16515
    Location:295 → 334
    RING-HC_LRSAM1; RING finger, HC subclass, found in leucine-rich repeat and sterile alpha motif-containing protein 1 (LRSAM1) and similar proteins
    pfam12483
    Location:86 → 235
    GIDE; E3 Ubiquitin ligase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8L7N4.1

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