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Dihydrolipoamide acetyltransferase, long form protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 841863, updated on 18-Sep-2024

Summary

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Official Full Name
Dihydrolipoamide acetyltransferase, long form protein
Primary source
TAIR:AT1G54220
Locus tag
AT1G54220
See related
Araport:AT1G54220
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
F20D21.4; F20D21_4
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Genomic context

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Location:
chromosome: 1
Exon count:
19
Sequence:
Chromosome: 1; NC_003070.9 (20246026..20250345, complement)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene proline-rich family protein Neighboring gene Ribosomal protein L18ae family Neighboring gene Winged helix-turn-helix transcription repressor DNA-binding protein Neighboring gene winged-helix DNA-binding transcription factor family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Lipoic acid-dependent oxidative catabolism of alpha-keto acids in mitochondria provides evidence for branched-chain amino acid catabolism in Arabidopsis. Taylor NL, et al. Plant Physiol, 2004 Feb. PMID 14764908, Free PMC Article
  2. Heterogeneity of the mitochondrial proteome for photosynthetic and non-photosynthetic Arabidopsis metabolism. Lee CP, et al. Mol Cell Proteomics, 2008 Jul. PMID 18385124
  3. The Extra-Pathway Interactome of the TCA Cycle: Expected and Unexpected Metabolic Interactions. Zhang Y, et al. Plant Physiol, 2018 Jul. PMID 29794018, Free PMC Article
  4. Proteomic analysis of the 26S proteasome reveals its direct interaction with transit peptides of plastid protein precursors for their degradation. Sako K, et al. J Proteome Res, 2014 Jul 3. PMID 24846764
  5. Experimental analysis of the Arabidopsis mitochondrial proteome highlights signaling and regulatory components, provides assessment of targeting prediction programs, and indicates plant-specific mitochondrial proteins. Heazlewood JL, et al. Plant Cell, 2004 Jan. PMID 14671022, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001036109.1
NM_104300.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables dihydrolipoyllysine-residue acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in acetyl-CoA biosynthetic process from pyruvate IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISM
Inferred from Sequence Model
more info
  
located_in nucleus HDA PubMed 
part_of pyruvate dehydrogenase complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Dihydrolipoamide acetyltransferase, long form protein
NP_001031186.1
  • Dihydrolipoamide acetyltransferase, long form protein; FUNCTIONS IN: dihydrolipoyllysine-residue acetyltransferase activity, acyltransferase activity; INVOLVED IN: pyruvate metabolic process, metabolic process; LOCATED IN: mitochondrion; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: 2-oxo acid dehydrogenase, lipoyl-binding site (InterPro:IPR003016), Dihydrolipoamide acetyltransferase, long form (InterPro:IPR006257), E3 binding (InterPro:IPR004167), 2-oxoacid dehydrogenase acyltransferase, catalytic domain (InterPro:IPR001078), Single hybrid motif (InterPro:IPR011053), Biotin/lipoyl attachment (InterPro:IPR000089); BEST Arabidopsis thaliana protein match is: Dihydrolipoamide acetyltransferase, long form protein (TAIR:AT3G13930.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
NP_564654.1
  • Dihydrolipoamide acetyltransferase, long form protein; FUNCTIONS IN: dihydrolipoyllysine-residue acetyltransferase activity, acyltransferase activity; INVOLVED IN: pyruvate metabolic process, metabolic process, acetyl-CoA biosynthetic process from pyruvate; LOCATED IN: mitochondrion; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: 2-oxo acid dehydrogenase, lipoyl-binding site (InterPro:IPR003016), Dihydrolipoamide acetyltransferase, long form (InterPro:IPR006257), E3 binding (InterPro:IPR004167), 2-oxoacid dehydrogenase acyltransferase, catalytic domain (InterPro:IPR001078), Single hybrid motif (InterPro:IPR011053), Biotin/lipoyl attachment (InterPro:IPR000089); BEST Arabidopsis thaliana protein match is: Dihydrolipoamide acetyltransferase, long form protein (TAIR:AT3G13930.1); Has 21519 Blast hits to 19723 proteins in 2310 species: Archae - 104; Bacteria - 12081; Metazoa - 737; Fungi - 478; Plants - 377; Viruses - 0; Other Eukaryotes - 7742 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    20246026..20250345 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_104300.4 → NP_564654.1  Dihydrolipoamide acetyltransferase, long form protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_564654.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q5M729, Q8L787, Q94IP5, Q9SLL0
    UniProtKB/TrEMBL
    A0A178W5Y1, A0A5S9WPJ8, A0A7G2E0R9
    Conserved Domains (1) summary
    PLN02744
    Location:2 → 539
    PLN02744; dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex

  2. NM_001036109.1 → NP_001031186.1  Dihydrolipoamide acetyltransferase, long form protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001031186.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q5M729, Q8L787, Q94IP5, Q9SLL0
    UniProtKB/TrEMBL
    A0A178W5Y1, A0A5S9WPJ8, A0A7G2E0R9
    Conserved Domains (1) summary
    PLN02744
    Location:2 → 539
    PLN02744; dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5M729.1

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