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ATPI4K ALPHA Phosphatidylinositol 3- and 4-kinase family protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 841357, updated on 18-Sep-2024

Summary

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Official Symbol
ATPI4K ALPHA
Official Full Name
Phosphatidylinositol 3- and 4-kinase family protein
Primary source
TAIR:AT1G49340
Locus tag
AT1G49340
See related
Araport:AT1G49340
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Summary
Encodes a phosphatidylinositol 4-kinase that is expressed in inflorescences and shoots.
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Genomic context

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See ATPI4K ALPHA in Genome Data Viewer
Location:
chromosome: 1
Exon count:
26
Sequence:
Chromosome: 1; NC_003070.9 (18252050..18264672)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene unknown seed protein like 1 Neighboring gene hydroxyproline-rich glycoprotein family protein Neighboring gene pfkB-like carbohydrate kinase family protein Neighboring gene ncRNA Neighboring gene F-box family protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A phosphatidylinositol 4-kinase pleckstrin homology domain that binds phosphatidylinositol 4-monophosphate. Stevenson JM, et al. J Biol Chem, 1998 Aug 28. PMID 9712908
  2. Differential regulation of two Arabidopsis type III phosphatidylinositol 4-kinase isoforms. A regulatory role for the pleckstrin homology domain. Stevenson-Paulik J, et al. Plant Physiol, 2003 Jun. PMID 12805633, Free PMC Article
  3. A nanodomain-anchored scaffolding complex is required for the function and localization of phosphatidylinositol 4-kinase alpha in plants. Noack LC, et al. Plant Cell, 2022 Jan 20. PMID 34010411, Free PMC Article
  4. Arabidopsis plasmodesmal proteome. Fernandez-Calvino L, et al. PLoS One, 2011 Apr 20. PMID 21533090, Free PMC Article
  5. Global Analysis of Membrane-associated Protein Oligomerization Using Protein Correlation Profiling. McBride Z, et al. Mol Cell Proteomics, 2017 Nov. PMID 28887381, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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NM_001333375.1
NM_001333376.1
NM_103824.4
NM_180629.2

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables 1-phosphatidylinositol 4-kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables actin filament binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables lipid kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables lipid kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables phosphatidic acid binding IDA
Inferred from Direct Assay
more info
 PubMed 
NOT enables phosphatidylinositol-3,4-bisphosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
NOT enables phosphatidylinositol-3-phosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol-4,5-bisphosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol-4-phosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in phosphatidylinositol phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within pollen development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of shoot system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within root development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  
located_in cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extrinsic component of cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane microdomain IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus HDA PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
part_of plasma membrane protein complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasmodesma HDA PubMed 

General protein information

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Preferred Names
Phosphatidylinositol 3- and 4-kinase family protein
NP_175359.2
  • ATPI4K ALPHA; FUNCTIONS IN: 1-phosphatidylinositol 4-kinase activity, inositol or phosphatidylinositol kinase activity; INVOLVED IN: protein amino acid phosphorylation; LOCATED IN: plasma membrane; EXPRESSED IN: shoot, male gametophyte, flower, pollen tube; EXPRESSED DURING: L mature pollen stage, M germinated pollen stage; CONTAINS InterPro DOMAIN/s: Phosphatidylinositol 3-/4-kinase, catalytic (InterPro:IPR000403), Phosphoinositide 3-kinase, accessory (PIK) domain (InterPro:IPR001263), Phosphatidylinositol Kinase (InterPro:IPR015433), Armadillo-type fold (InterPro:IPR016024), Phosphatidylinositol 3/4-kinase, conserved site (InterPro:IPR018936), Protein kinase-like domain (InterPro:IPR011009); BEST Arabidopsis thaliana protein match is: Protein kinase superfamily protein (TAIR:AT1G51040.1); Has 2472 Blast hits to 2328 proteins in 267 species: Archae - 0; Bacteria - 0; Metazoa - 1180; Fungi - 474; Plants - 245; Viruses - 4; Other Eukaryotes - 569 (source: NCBI BLink).
NP_850960.1
  • ATPI4K ALPHA; FUNCTIONS IN: 1-phosphatidylinositol 4-kinase activity, inositol or phosphatidylinositol kinase activity; INVOLVED IN: protein amino acid phosphorylation; LOCATED IN: plasma membrane; EXPRESSED IN: shoot, male gametophyte, flower, pollen tube; EXPRESSED DURING: L mature pollen stage, M germinated pollen stage; CONTAINS InterPro DOMAIN/s: Phosphoinositide 3-kinase, accessory (PIK) domain (InterPro:IPR001263), Phosphatidylinositol 3-/4-kinase, catalytic (InterPro:IPR000403), Phosphatidylinositol Kinase (InterPro:IPR015433), Armadillo-type fold (InterPro:IPR016024), Phosphatidylinositol 3/4-kinase, conserved site (InterPro:IPR018936), Protein kinase-like domain (InterPro:IPR011009); BEST Arabidopsis thaliana protein match is: Protein kinase superfamily protein (TAIR:AT1G51040.1); Has 2472 Blast hits to 2328 proteins in 267 species: Archae - 0; Bacteria - 0; Metazoa - 1180; Fungi - 474; Plants - 245; Viruses - 4; Other Eukaryotes - 569 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    18252050..18264672
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_180629.2 → NP_850960.1  Phosphatidylinositol 3- and 4-kinase family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_850960.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O81129, Q9SXA1
    UniProtKB/TrEMBL
    A0A5S9WNF1, A0A654ESP1
    Conserved Domains (2) summary
    cd05167
    Location:1728 → 2027
    PI4Kc_III_alpha; Catalytic domain of Type III Phosphoinositide 4-kinase alpha
    cl00271
    Location:1489 → 1667
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in ...

  2. NM_001333375.1 → NP_001323160.1  Phosphatidylinositol 3- and 4-kinase family protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8AWA3, A0A7G2DZA9

  3. NM_103824.4 → NP_175359.2  Phosphatidylinositol 3- and 4-kinase family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_175359.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O81129, Q9SXA1
    UniProtKB/TrEMBL
    A0A5S9WNF1, A0A654ESP1
    Conserved Domains (2) summary
    cd05167
    Location:1728 → 2027
    PI4Kc_III_alpha; Catalytic domain of Type III Phosphoinositide 4-kinase alpha
    cl00271
    Location:1489 → 1667
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in ...

  4. NM_001333376.1 → NP_001323161.1  Phosphatidylinositol 3- and 4-kinase family protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8AWA3, A0A7G2DZA9
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9SXA1.2

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