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PMEAMT S-adenosyl-L-methionine-dependent methyltransferases superfamily protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 841281, updated on 18-Sep-2024

Summary

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Official Symbol
PMEAMT
Official Full Name
S-adenosyl-L-methionine-dependent methyltransferases superfamily protein
Primary source
TAIR:AT1G48600
Locus tag
AT1G48600
See related
Araport:AT1G48600
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
AtPMEAMT; phosphoethanolamine N-methyltransferase; T1N15.23; T1N15_23
Summary
Encodes a phosphoethanolamine N-methyltransferase that catalyses the last two methylation steps of the three sequential methylations of phosphoethanolamine (PEA) that are required for the synthesis of phosphocholine (PCho) in plants.
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Genomic context

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See PMEAMT in Genome Data Viewer
Location:
chromosome: 1
Exon count:
12
Sequence:
Chromosome: 1; NC_003070.9 (17965871..17969354)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Calcium-dependent lipid-binding (CaLB domain) family protein Neighboring gene ncRNA Neighboring gene Flavoprotein Neighboring gene AT hook motif-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A Methyltransferase Trio Essential for Phosphatidylcholine Biosynthesis and Growth. Liu YC, et al. Plant Physiol, 2019 Feb. PMID 30518673, Free PMC Article
  2. Identification of phosphomethylethanolamine N-methyltransferase from Arabidopsis and its role in choline and phospholipid metabolism. BeGora MD, et al. J Biol Chem, 2010 Sep 17. PMID 20650897, Free PMC Article
  3. Novel Aquaporin Regulatory Mechanisms Revealed by Interactomics. Bellati J, et al. Mol Cell Proteomics, 2016 Nov. PMID 27609422, Free PMC Article
  4. Discovering the RNA-Binding Proteome of Plant Leaves with an Improved RNA Interactome Capture Method. Bach-Pages M, et al. Biomolecules, 2020 Apr 24. PMID 32344669, Free PMC Article
  5. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PMT2 (or PMEAMT; At1g48600) has a critical role in phosphatidylcholine biosynthesis and growth.
    Title: A Methyltransferase Trio Essential for Phosphatidylcholine Biosynthesis and Growth.
  2. phosphomethylethanolamine N-methyltransferase is involved in Arabidopsis choline and phospholipid metabolism.
    Title: Identification of phosphomethylethanolamine N-methyltransferase from Arabidopsis and its role in choline and phospholipid metabolism.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Miscellaneous features

  • Loc: 17965933-17966010 AT1G48600.uORF1
NM_103756.3
NM_202264.2

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphoethanolamine N-methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within methylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within phosphatidylcholine biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phosphatidylcholine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phosphatidylcholine biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
S-adenosyl-L-methionine-dependent methyltransferases superfamily protein
NP_175293.1
  • phosphoethanolamine N-methyltransferase (PMEAMT); FUNCTIONS IN: phosphomethylethanolamine N-methyltransferase activity, phosphoethanolamine N-methyltransferase activity; INVOLVED IN: phosphatidylcholine biosynthetic process; EXPRESSED IN: sperm cell, cotyledon, male gametophyte, guard cell, pollen tube; EXPRESSED DURING: L mature pollen stage, M germinated pollen stage; CONTAINS InterPro DOMAIN/s: Methyltransferase type 11 (InterPro:IPR013216); BEST Arabidopsis thaliana protein match is: S-adenosyl-L-methionine-dependent methyltransferases superfamily protein (TAIR:AT3G18000.1); Has 21397 Blast hits to 20726 proteins in 2642 species: Archae - 625; Bacteria - 15762; Metazoa - 271; Fungi - 989; Plants - 576; Viruses - 5; Other Eukaryotes - 3169 (source: NCBI BLink).
NP_973993.1
  • phosphoethanolamine N-methyltransferase (PMEAMT); FUNCTIONS IN: phosphomethylethanolamine N-methyltransferase activity, phosphoethanolamine N-methyltransferase activity; INVOLVED IN: phosphatidylcholine biosynthetic process; EXPRESSED IN: sperm cell, cotyledon, male gametophyte, guard cell, pollen tube; EXPRESSED DURING: L mature pollen stage, M germinated pollen stage; CONTAINS InterPro DOMAIN/s: Methyltransferase type 11 (InterPro:IPR013216); BEST Arabidopsis thaliana protein match is: S-adenosyl-L-methionine-dependent methyltransferases superfamily protein (TAIR:AT3G18000.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    17965871..17969354
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_202264.2 → NP_973993.1  S-adenosyl-L-methionine-dependent methyltransferases superfamily protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_973993.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    F4HYI6, Q944H0, Q9LP63, Q9LP64
    UniProtKB/TrEMBL
    A0A178WLJ9, A0A5S9WMS2
    Conserved Domains (1) summary
    PLN02336
    Location:17 → 491
    PLN02336; phosphoethanolamine N-methyltransferase

  2. NM_103756.3 → NP_175293.1  S-adenosyl-L-methionine-dependent methyltransferases superfamily protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_175293.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178WLU9, A0A5S9WMS2
    Conserved Domains (1) summary
    PLN02336
    Location:1 → 475
    PLN02336; phosphoethanolamine N-methyltransferase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q944H0.2

Gene LinkOut

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