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LRRIQ1 leucine rich repeats and IQ motif containing 1 [ Homo sapiens (human) ]

Gene ID: 84125, updated on 14-Nov-2024

Summary

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Official Symbol
LRRIQ1provided by HGNC
Official Full Name
leucine rich repeats and IQ motif containing 1provided by HGNC
Primary source
HGNC:HGNC:25708
See related
Ensembl:ENSG00000133640 MIM:620922; AllianceGenome:HGNC:25708
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to be involved in regulation of signal transduction. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis (RPKM 3.9), lung (RPKM 0.9) and 4 other tissues See more
Orthologs
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Genomic context

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See LRRIQ1 in Genome Data Viewer
Location:
12q21.31
Exon count:
37
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (85036351..85272805)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (85015741..85253151)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (85430129..85638883)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:85306245-85306792 Neighboring gene uncharacterized LOC102724680 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:85306793-85307339 Neighboring gene NANOG hESC enhancer GRCh37_chr12:85397904-85398436 Neighboring gene Sharpr-MPRA regulatory region 14945 Neighboring gene tetraspanin 19 Neighboring gene Sharpr-MPRA regulatory region 79 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr12:85711317-85711919 and GRCh37_chr12:85711920-85712521 Neighboring gene long intergenic non-protein coding RNA 2820 Neighboring gene ALX homeobox 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6693 Neighboring gene uncharacterized LOC107984537 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6694

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. Nagase T, et al. DNA Res, 2001 Apr 27. PMID 11347906
  2. Cullin 1 (CUL1) Promotes Primary Ciliogenesis through the Induction of Ubiquitin-Proteasome-Dependent Dvl2 Degradation. Kim SO, et al. Int J Mol Sci, 2021 Jul 15. PMID 34299191, Free PMC Article
  3. Genome-scale RNAi screen for host factors required for HIV replication. Zhou H, et al. Cell Host Microbe, 2008 Nov 13. PMID 18976975
  4. Tumor suppressor BAP1 nuclear import is governed by transportin-1. Yang TJ, et al. J Cell Biol, 2022 Jun 6. PMID 35446349, Free PMC Article
  5. Pulse-SILAC and Interactomics Reveal Distinct DDB1-CUL4-Associated Factors, Cellular Functions, and Protein Substrates. Raisch J, et al. Mol Cell Proteomics, 2023 Oct. PMID 37689310, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of leucine-rich repeats and IQ motif containing 1 (LRRIQ1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ12303

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
leucine-rich repeat and IQ domain-containing protein 1
Names
testicular tissue protein Li 111

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001079910.2 → NP_001073379.1  leucine-rich repeat and IQ domain-containing protein 1

    See identical proteins and their annotated locations for NP_001073379.1

    Status: VALIDATED

    Source sequence(s)
    AB058704, AC079631, AU122206, BU608190, BU677204, CA502842, DB447399, DN831755
    Consensus CDS
    CCDS41816.1
    UniProtKB/Swiss-Prot
    Q567P4, Q96JM4, Q9BS17, Q9HA36
    UniProtKB/TrEMBL
    A0A140VJN5
    Related
    ENSP00000376910.2, ENST00000393217.7
    Conserved Domains (5) summary
    smart00015
    Location:1338 → 1354
    IQ; Calmodulin-binding motif
    cd00116
    Location:963 → 1095
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:820 → 841
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:818 → 856
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:1037 → 1091
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    85036351..85272805
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011538819.4 → XP_011537121.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X3

    Conserved Domains (5) summary
    smart00015
    Location:1338 → 1354
    IQ; Calmodulin-binding motif
    cd00116
    Location:963 → 1095
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:820 → 841
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:818 → 856
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:1037 → 1091
    LRR_8; Leucine rich repeat

  2. XM_024449222.2 → XP_024304990.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X7

    Conserved Domains (5) summary
    smart00015
    Location:1338 → 1354
    IQ; Calmodulin-binding motif
    sd00033
    Location:820 → 841
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:1037 → 1091
    LRR_8; Leucine rich repeat
    cl26018
    Location:971 → 1108
    NEL; C-terminal novel E3 ligase, LRR-interacting
    cl26511
    Location:162 → 644
    Neuromodulin_N; Gap junction protein N-terminal region

  3. XM_011538817.3 → XP_011537119.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X1

    Conserved Domains (6) summary
    smart00015
    Location:1338 → 1354
    IQ; Calmodulin-binding motif
    cd00116
    Location:963 → 1095
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:820 → 841
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:818 → 856
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:1037 → 1091
    LRR_8; Leucine rich repeat
    pfam14988
    Location:164 → 343
    DUF4515; Domain of unknown function (DUF4515)

  4. XM_024449221.2 → XP_024304989.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X6

    Conserved Domains (5) summary
    smart00015
    Location:1338 → 1354
    IQ; Calmodulin-binding motif
    sd00033
    Location:820 → 841
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:1037 → 1091
    LRR_8; Leucine rich repeat
    cl26018
    Location:971 → 1108
    NEL; C-terminal novel E3 ligase, LRR-interacting
    cl26511
    Location:162 → 644
    Neuromodulin_N; Gap junction protein N-terminal region

  5. XM_047429655.1 → XP_047285611.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X12

  6. XM_011538818.3 → XP_011537120.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X2

    Conserved Domains (5) summary
    smart00015
    Location:1338 → 1354
    IQ; Calmodulin-binding motif
    cd00116
    Location:963 → 1095
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:820 → 841
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:818 → 856
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:1037 → 1091
    LRR_8; Leucine rich repeat

  7. XM_024449220.2 → XP_024304988.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X5

    Conserved Domains (5) summary
    smart00015
    Location:1338 → 1354
    IQ; Calmodulin-binding motif
    sd00033
    Location:820 → 841
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:1037 → 1091
    LRR_8; Leucine rich repeat
    cl26018
    Location:971 → 1108
    NEL; C-terminal novel E3 ligase, LRR-interacting
    cl26511
    Location:162 → 644
    Neuromodulin_N; Gap junction protein N-terminal region

  8. XM_047429651.1 → XP_047285607.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X4

  9. XM_047429652.1 → XP_047285608.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X4

  10. XM_047429656.1 → XP_047285612.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X13

  11. XM_047429657.1 → XP_047285613.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X14

  12. XM_047429653.1 → XP_047285609.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X8

  13. XM_024449223.2 → XP_024304991.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X9

    Conserved Domains (5) summary
    smart00015
    Location:1338 → 1354
    IQ; Calmodulin-binding motif
    sd00033
    Location:820 → 841
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:1037 → 1091
    LRR_8; Leucine rich repeat
    cl26018
    Location:971 → 1108
    NEL; C-terminal novel E3 ligase, LRR-interacting
    cl26511
    Location:162 → 644
    Neuromodulin_N; Gap junction protein N-terminal region

  14. XM_047429654.1 → XP_047285610.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X11

  15. XM_011538823.3 → XP_011537125.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X10

    Conserved Domains (5) summary
    smart00015
    Location:1338 → 1354
    IQ; Calmodulin-binding motif
    cd00116
    Location:963 → 1095
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:820 → 841
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:818 → 856
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:1037 → 1091
    LRR_8; Leucine rich repeat

  16. XM_011538824.3 → XP_011537126.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X16

    Related
    ENST00000525971.6
    Conserved Domains (5) summary
    smart00015
    Location:1338 → 1354
    IQ; Calmodulin-binding motif
    cd00116
    Location:963 → 1095
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:820 → 841
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:818 → 856
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:1037 → 1091
    LRR_8; Leucine rich repeat

  17. XM_011538825.3 → XP_011537127.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X15

    Conserved Domains (3) summary
    sd00033
    Location:820 → 841
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:818 → 856
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:1015 → 1070
    LRR_8; Leucine rich repeat

RNA

  1. XR_944764.3 RNA Sequence

  2. XR_944765.3 RNA Sequence

  3. XR_944766.3 RNA Sequence

  4. XR_001748890.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    85015741..85253151
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054373435.1 → XP_054229410.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X3

  2. XM_054373440.1 → XP_054229415.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X7

  3. XM_054373433.1 → XP_054229408.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X1

  4. XM_054373439.1 → XP_054229414.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X6

  5. XM_054373445.1 → XP_054229420.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X12

  6. XM_054373434.1 → XP_054229409.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X2

  7. XM_054373438.1 → XP_054229413.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X5

  8. XM_054373436.1 → XP_054229411.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X4

  9. XM_054373437.1 → XP_054229412.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X4

  10. XM_054373446.1 → XP_054229421.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X13

  11. XM_054373447.1 → XP_054229422.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X14

  12. XM_054373441.1 → XP_054229416.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X8

  13. XM_054373442.1 → XP_054229417.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X9

  14. XM_054373444.1 → XP_054229419.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X11

  15. XM_054373443.1 → XP_054229418.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X10

  16. XM_054373448.1 → XP_054229423.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X15

RNA

  1. XR_008488693.1 RNA Sequence

  2. XR_008488694.1 RNA Sequence

  3. XR_008488695.1 RNA Sequence

  4. XR_008488696.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_032165.3: Suppressed sequence

    Description
    NM_032165.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96JM4.3 GenPept UniProtKB/Swiss-Prot:Q96JM4

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