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3BETAHSD/D1 3beta-hydroxysteroid-dehydrogenase/decarboxylase isoform 1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 841132, updated on 14-Nov-2024

Summary

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Official Symbol
3BETAHSD/D1
Official Full Name
3beta-hydroxysteroid-dehydrogenase/decarboxylase isoform 1
Primary source
TAIR:AT1G47290
Locus tag
AT1G47290
See related
Araport:AT1G47290
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
3beta-hydroxysteroid- dehydrogenase/decarboxylase isoform 1; 3beta-hydroxysteroid-dehydrogenase/decarboxylase isoform 1; AT3BETAHSD/D; AT3BETAHSD/D1; T3F24.9; T3F24_9
Summary
Encodes an enzyme with 3beta-hydroxysteroid dehydrogenase/C4-decarboxylase activity <i>in vitro</i>. The activity of the enzyme was determined using microsomal extracts of yeast overexpressing the <i>Arabidopsis</i> gene. Cytosolic fractions failed to be associated to the activity, leading to the speculation that the enzyme is membrane-bound.
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Genomic context

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See 3BETAHSD/D1 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
10
Sequence:
Chromosome: 1; NC_003070.9 (17335751..17339275)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Cystathionine beta-synthase (CBS) family protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene F-box family protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Homology modeling and site-directed mutagenesis reveal catalytic key amino acids of 3beta-hydroxysteroid-dehydrogenase/C4-decarboxylase from Arabidopsis. Rahier A, et al. Plant Physiol, 2009 Apr. PMID 19218365, Free PMC Article
  2. Overexpression of 3β-hydroxysteroid dehydrogenases/C-4 decarboxylases causes growth defects possibly due to abnormal auxin transport in Arabidopsis. Kim B, et al. Mol Cells, 2012 Jul. PMID 22673766, Free PMC Article
  3. Molecular and enzymatic characterizations of novel bifunctional 3beta-hydroxysteroid dehydrogenases/C-4 decarboxylases from Arabidopsis thaliana. Rahier A, et al. J Biol Chem, 2006 Sep 15. PMID 16835224
  4. A Pan-plant Protein Complex Map Reveals Deep Conservation and Novel Assemblies. McWhite CD, et al. Cell, 2020 Apr 16. PMID 32191846, Free PMC Article
  5. Evidence for network evolution in an Arabidopsis interactome map. Arabidopsis Interactome Mapping Consortium. Science, 2011 Jul 29. PMID 21798944, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Arabidopsis 3betaHSD/D genes thus appears to affect auxin transporter activity, possibly by altering sterol composition in the membranes.
    Title: Overexpression of 3β-hydroxysteroid dehydrogenases/C-4 decarboxylases causes growth defects possibly due to abnormal auxin transport in Arabidopsis.
  2. 3betaHSD/D is a bifunctional short-chain dehydrogenase/reductase protein. Three-dimensional homology modeling was used to identify key amino acids involved in 4alpha-carboxy-sterol and NAD binding and catalysis of 3betaHSD/D. [3betaHSD/D]
    Title: Homology modeling and site-directed mutagenesis reveal catalytic key amino acids of 3beta-hydroxysteroid-dehydrogenase/C4-decarboxylase from Arabidopsis.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_103623.5
NM_179448.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating) [NAD(+)] activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating) [NAD(+)] activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
3beta-hydroxysteroid-dehydrogenase/decarboxylase isoform 1
NP_564502.1
  • 3beta-hydroxysteroid-dehydrogenase/decarboxylase isoform 1 (3BETAHSD/D1); FUNCTIONS IN: 3-beta-hydroxy-delta5-steroid dehydrogenase activity, sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity; INVOLVED IN: steroid biosynthetic process, metabolic process; LOCATED IN: membrane; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: 3-beta hydroxysteroid dehydrogenase/isomerase (InterPro:IPR002225), NAD(P)-binding domain (InterPro:IPR016040); BEST Arabidopsis thaliana protein match is: 3beta-hydroxysteroid-dehydrogenase/decarboxylase isoform 2 (TAIR:AT2G26260.1); Has 24441 Blast hits to 24428 proteins in 2873 species: Archae - 619; Bacteria - 15419; Metazoa - 693; Fungi - 529; Plants - 1563; Viruses - 132; Other Eukaryotes - 5486 (source: NCBI BLink).
NP_849779.1
  • 3beta-hydroxysteroid-dehydrogenase/decarboxylase isoform 1 (3BETAHSD/D1); FUNCTIONS IN: 3-beta-hydroxy-delta5-steroid dehydrogenase activity, sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity; INVOLVED IN: steroid biosynthetic process, metabolic process; LOCATED IN: membrane; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: NAD(P)-binding domain (InterPro:IPR016040), 3-beta hydroxysteroid dehydrogenase/isomerase (InterPro:IPR002225); BEST Arabidopsis thaliana protein match is: 3beta-hydroxysteroid-dehydrogenase/decarboxylase isoform 2 (TAIR:AT2G26260.1); Has 24445 Blast hits to 24432 proteins in 2873 species: Archae - 619; Bacteria - 15430; Metazoa - 691; Fungi - 529; Plants - 1560; Viruses - 132; Other Eukaryotes - 5484 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    17335751..17339275
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_179448.4 → NP_849779.1  3beta-hydroxysteroid-dehydrogenase/decarboxylase isoform 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_849779.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0VH36, Q8LER8, Q9FX01
    UniProtKB/TrEMBL
    A0A178WKM2, A0A5S9WMN0
    Conserved Domains (2) summary
    cd09813
    Location:11 → 358
    3b-HSD-NSDHL-like_SDR_e; human NSDHL (NAD(P)H steroid dehydrogenase-like protein)-like, extended (e) SDRs
    pfam01073
    Location:13 → 288
    3Beta_HSD; 3-beta hydroxysteroid dehydrogenase/isomerase family

  2. NM_103623.5 → NP_564502.1  3beta-hydroxysteroid-dehydrogenase/decarboxylase isoform 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_564502.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178WKM2, A0A5S9WMN0
    Conserved Domains (2) summary
    cd09813
    Location:11 → 358
    3b-HSD-NSDHL-like_SDR_e; human NSDHL (NAD(P)H steroid dehydrogenase-like protein)-like, extended (e) SDRs
    pfam01073
    Location:13 → 288
    3Beta_HSD; 3-beta hydroxysteroid dehydrogenase/isomerase family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9FX01.1

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