U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ACC1 acetyl-CoA carboxylase 1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 840521, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
ACC1
Official Full Name
acetyl-CoA carboxylase 1
Primary source
TAIR:AT1G36160
Locus tag
AT1G36160
See related
Araport:AT1G36160
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
acetyl-CoA carboxylase 1; AT-ACC1; EMB22; EMBRYO DEFECTIVE 22; GK; GLOSSYHEAD 1; GSD1; GURKE; PAS3; PASTICCINO 3; SENSITIVE TO FREEZING 3; SFR3
Summary
Encodes acetyl-CoA carboxylase. Mutant displays uncoordinated cell divisions which are enhanced by cytokinins. Mutant also has aberrant organization of the apical region in the embryo and abnormal root and shoot development and is deficient in freezing tolerance after cold acclimation. Essential for very long chain fatty acid elongation.
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See ACC1 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
32
Sequence:
Chromosome: 1; NC_003070.9 (13533168..13544015)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein Neighboring gene acetyl-CoA carboxylase 2 Neighboring gene pseudo

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The sensitive to freezing3 mutation of Arabidopsis thaliana is a cold-sensitive allele of homomeric acetyl-CoA carboxylase that results in cold-induced cuticle deficiencies. Amid A, et al. J Exp Bot, 2012 Sep. PMID 22791831, Free PMC Article
  2. The glossyhead1 allele of ACC1 reveals a principal role for multidomain acetyl-coenzyme A carboxylase in the biosynthesis of cuticular waxes by Arabidopsis. Lü S, et al. Plant Physiol, 2011 Nov. PMID 21949210, Free PMC Article
  3. gurke and pasticcino3 mutants affected in embryo development are impaired in acetyl-CoA carboxylase. Baud S, et al. EMBO Rep, 2004 May. PMID 15088065, Free PMC Article
  4. Multifunctional acetyl-CoA carboxylase 1 is essential for very long chain fatty acid elongation and embryo development in Arabidopsis. Baud S, et al. Plant J, 2003 Jan. PMID 12943542
  5. The GURKE gene is required for normal organization of the apical region in the Arabidopsis embryo. Torres-Ruiz RA, et al. Plant J, 1996 Dec. PMID 9011083

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. sensitive to freezing3(sfr3) is a missense mutation in aminoglycoside N1-acetyltransferase. Freezing sensitivity of sfr3 appears to be due to cuticular deficiencies that develop during cold acclimation.
    Title: The sensitive to freezing3 mutation of Arabidopsis thaliana is a cold-sensitive allele of homomeric acetyl-CoA carboxylase that results in cold-induced cuticle deficiencies.
  2. The gsd1 locus was mapped to chromosome 1, and the causal gene was identified as a new allele of Acetyl-Coenzyme A Carboxylase1 (ACC1), a gene encoding the main enzyme in cytosolic malonyl-coenzyme A synthesis.
    Title: The glossyhead1 allele of ACC1 reveals a principal role for multidomain acetyl-coenzyme A carboxylase in the biosynthesis of cuticular waxes by Arabidopsis.
  3. Data suggest that the lack of cytosolic malonyl-CoA is likely to be the initial factor leading to abnormal development in acetyl-CoA carboxylase 1 mutants.
    Title: gurke and pasticcino3 mutants affected in embryo development are impaired in acetyl-CoA carboxylase.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

NM_001198214.2
NM_103313.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables acetyl-CoA carboxylase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables biotin carboxylase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cold acclimation IMP
Inferred from Mutant Phenotype
more info
  
acts_upstream_of_or_within embryo development ending in seed dormancy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within fatty acid elongation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in malonyl-CoA biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within meristem structural organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within primary shoot apical meristem specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to cytokinin IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within root development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within shoot system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  
located_in nucleus HDA PubMed 

General protein information

Go to the top of the page Help
Preferred Names
acetyl-CoA carboxylase 1
NP_001185143.1
  • acetyl-CoA carboxylase 1 (ACC1); CONTAINS InterPro DOMAIN/s: Acetyl-coenzyme A carboxyltransferase, N-terminal (InterPro:IPR011762), Carboxyl transferase (InterPro:IPR000022), Biotin/lipoyl attachment (InterPro:IPR000089), Carbamoyl phosphate synthase, large subunit, N-terminal (InterPro:IPR005481), PreATP-grasp-like fold (InterPro:IPR016185), ATP-grasp fold (InterPro:IPR011761), Biotin carboxylase, C-terminal (InterPro:IPR005482), Single hybrid motif (InterPro:IPR011053), Carbamoyl phosphate synthetase, large subunit, ATP-binding (InterPro:IPR005479), Acetyl-CoA carboxylase, central region (InterPro:IPR013537), Biotin carboxylation domain (InterPro:IPR011764), Biotin-binding site (InterPro:IPR001882), ATP-grasp fold, subdomain 2 (InterPro:IPR013816), Acetyl-coenzyme A carboxyltransferase, C-terminal (InterPro:IPR011763), Pre-ATP-grasp fold (InterPro:IPR013817), Rudiment single hybrid motif (InterPro:IPR011054); BEST Arabidopsis thaliana protein match is: acetyl-CoA carboxylase 2 (TAIR:AT1G36180.1).
NP_174849.2
  • acetyl-CoA carboxylase 1 (ACC1); FUNCTIONS IN: acetyl-CoA carboxylase activity; INVOLVED IN: in 7 processes; LOCATED IN: plasma membrane; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Acetyl-coenzyme A carboxyltransferase, N-terminal (InterPro:IPR011762), Carboxyl transferase (InterPro:IPR000022), Biotin/lipoyl attachment (InterPro:IPR000089), Carbamoyl phosphate synthase, large subunit, N-terminal (InterPro:IPR005481), PreATP-grasp-like fold (InterPro:IPR016185), ATP-grasp fold (InterPro:IPR011761), Biotin carboxylase, C-terminal (InterPro:IPR005482), Single hybrid motif (InterPro:IPR011053), Carbamoyl phosphate synthetase, large subunit, ATP-binding (InterPro:IPR005479), Acetyl-CoA carboxylase, central region (InterPro:IPR013537), Biotin carboxylation domain (InterPro:IPR011764), Biotin-binding site (InterPro:IPR001882), ATP-grasp fold, subdomain 2 (InterPro:IPR013816), Acetyl-coenzyme A carboxyltransferase, C-terminal (InterPro:IPR011763), Pre-ATP-grasp fold (InterPro:IPR013817), Rudiment single hybrid motif (InterPro:IPR011054); BEST Arabidopsis thaliana protein match is: acetyl-CoA carboxylase 2 (TAIR:AT1G36180.1); Has 35904 Blast hits to 31362 proteins in 3745 species: Archae - 652; Bacteria - 22267; Metazoa - 1934; Fungi - 1046; Plants - 1042; Viruses - 0; Other Eukaryotes - 8963 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    13533168..13544015
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001198214.2 → NP_001185143.1  acetyl-CoA carboxylase 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001185143.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0WNF3, Q38970, Q38971, Q9C8G1, Q9SKV1
    UniProtKB/TrEMBL
    A0A178W1F6, A0A5S9WJ11
    Conserved Domains (8) summary
    cd06850
    Location:679 → 741
    biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...
    COG0439
    Location:40 → 545
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    COG0511
    Location:601 → 741
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
    pfam00289
    Location:37 → 156
    CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
    pfam01039
    Location:1587 → 2139
    Carboxyl_trans; Carboxyl transferase domain
    pfam02785
    Location:432 → 539
    Biotin_carb_C; Biotin carboxylase C-terminal domain
    pfam08326
    Location:744 → 1485
    ACC_central; Acetyl-CoA carboxylase, central region
    cl17255
    Location:161 → 385
    ATP-grasp_4; ATP-grasp domain

  2. NM_103313.4 → NP_174849.2  acetyl-CoA carboxylase 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_174849.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0WNF3, Q38970, Q38971, Q9C8G1, Q9SKV1
    UniProtKB/TrEMBL
    A0A178W1F6, A0A5S9WJ11
    Conserved Domains (8) summary
    cd06850
    Location:679 → 741
    biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...
    COG0439
    Location:40 → 545
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    COG0511
    Location:601 → 741
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
    pfam00289
    Location:37 → 156
    CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
    pfam01039
    Location:1587 → 2139
    Carboxyl_trans; Carboxyl transferase domain
    pfam02785
    Location:432 → 539
    Biotin_carb_C; Biotin carboxylase C-terminal domain
    pfam08326
    Location:744 → 1485
    ACC_central; Acetyl-CoA carboxylase, central region
    cl17255
    Location:161 → 385
    ATP-grasp_4; ATP-grasp domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q38970.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools