U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

bco1 beta-carotene oxygenase 1 [ Danio rerio (zebrafish) ]

Gene ID: 84039, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
bco1provided by ZNC
Official Full Name
beta-carotene oxygenase 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-010508-1
See related
Ensembl:ENSDARG00000104256 AllianceGenome:ZFIN:ZDB-GENE-010508-1
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
bcdo; bcox; bcdo1; bcmo1; b-diox; bcmo1a
Summary
Enables beta-carotene 15,15'-dioxygenase activity. Acts upstream of or within eye photoreceptor cell differentiation and hindbrain development. Is expressed in gut; liver; neural crest; ovary; and xanthophore. Orthologous to human BCO1 (beta-carotene oxygenase 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See bco1 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (65272470..65290474)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (65048442..65066446)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene polycystic kidney disease 1 like 2a Neighboring gene beta-carotene oxygenase 1, like Neighboring gene bolA family member 3 Neighboring gene vesicle amine transport 1-like

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Photoreceptor morphology is severely affected in the beta,beta-carotene-15,15'-oxygenase (bcox) zebrafish morphant. Biehlmaier O, et al. Eur J Neurosci, 2005 Jan. PMID 15654843
  2. The evolution and functional divergence of the beta-carotene oxygenase gene family in teleost fish--exemplified by Atlantic salmon. Helgeland H, et al. Gene, 2014 Jun 15. PMID 24583166
  3. Identification and characterization of a mammalian enzyme catalyzing the asymmetric oxidative cleavage of provitamin A. Kiefer C, et al. J Biol Chem, 2001 Apr 27. PMID 11278918
  4. Global transcriptomic analysis of zebrafish in response to embryonic exposure to three antidepressants, amitriptyline, fluoxetine and mianserin. Wu M, et al. Aquat Toxicol, 2017 Nov. PMID 28992598
  5. Thyroid hormone regulates distinct paths to maturation in pigment cell lineages. Saunders LM, et al. Elife, 2019 May 29. PMID 31140974, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables beta-carotene 15,15'-dioxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables beta-carotene 15,15'-dioxygenase activity IDA
Inferred from Direct Assay
more info
  
enables beta-carotene 15,15'-dioxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables carotenoid dioxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ferrous iron binding NAS
Non-traceable Author Statement
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carotene catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within eye photoreceptor cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within hindbrain development IMP
Inferred from Mutant Phenotype
more info
  
involved_in retinal metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
beta,beta-carotene 15,15'-dioxygenase
Names
beta-carotene 15, 15'-dioxygenase
beta-carotene 15,15'-monooxygenase 1a
NP_001315424.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001328495.1 → NP_001315424.1  beta,beta-carotene 15,15'-dioxygenase

    Status: VALIDATED

    Source sequence(s)
    CU682354, CU856172
    UniProtKB/TrEMBL
    A0A8M1PAC3, Q7ZTS0
    Related
    ENSDARP00000137596.1, ENSDART00000162471.2
    Conserved Domains (1) summary
    pfam03055
    Location:10 → 513
    RPE65; Retinal pigment epithelial membrane protein

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    65272470..65290474
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_131798.2: Suppressed sequence

    Description
    NM_131798.2: This RefSeq was removed because currently there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.