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PDH-E1 ALPHA pyruvate dehydrogenase E1 alpha [ Arabidopsis thaliana (thale cress) ]

Gene ID: 839429, updated on 18-Sep-2024

Summary

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Official Symbol
PDH-E1 ALPHA
Official Full Name
pyruvate dehydrogenase E1 alpha
Primary source
TAIR:AT1G01090
Locus tag
AT1G01090
See related
Araport:AT1G01090
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
pyruvate dehydrogenase E1 alpha; T25K16.8; T25K16_8
Summary
pyruvate dehydrogenase E1 alpha subunit
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Genomic context

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See PDH-E1 ALPHA in Genome Data Viewer
Location:
chromosome: 1
Exon count:
3
Sequence:
Chromosome: 1; NC_003070.9 (47234..49304, complement)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene RNA-binding (RRM/RBD/RNP motifs) family protein Neighboring gene 60S acidic ribosomal protein family Neighboring gene IQ-domain 18

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cloning and molecular analyses of the Arabidopsis thaliana plastid pyruvate dehydrogenase subunits. Johnston ML, et al. Biochim Biophys Acta, 1997 Oct 20. PMID 9393637
  2. Cosuppression of RBCS3B in Arabidopsis leads to severe photoinhibition caused by ROS accumulation. Zhan GM, et al. Plant Cell Rep, 2014 Jul. PMID 24682522
  3. Redox Conformation-Specific Protein-Protein Interactions of the 2-Cysteine Peroxiredoxin in Arabidopsis. Liebthal M, et al. Antioxidants (Basel), 2020 Jun 11. PMID 32545358, Free PMC Article
  4. Toward an interaction map of the two-component signaling pathway of Arabidopsis thaliana. Dortay H, et al. J Proteome Res, 2008 Sep. PMID 18642946
  5. Proteomic analysis of the 26S proteasome reveals its direct interaction with transit peptides of plastid protein precursors for their degradation. Sako K, et al. J Proteome Res, 2014 Jul 3. PMID 24846764

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_099991.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables pyruvate dehydrogenase (acetyl-transferring) activity IEA
Inferred from Electronic Annotation
more info
  
enables pyruvate dehydrogenase (acetyl-transferring) activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in acetyl-CoA biosynthetic process from pyruvate IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in chloroplast HDA PubMed 
located_in chloroplast envelope HDA PubMed 
located_in chloroplast stroma HDA PubMed 
NOT located_in cytosol RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
located_in mitochondrion ISM
Inferred from Sequence Model
more info
  
located_in plastid HDA PubMed 
located_in plastid ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
pyruvate dehydrogenase E1 alpha
NP_171617.1
  • pyruvate dehydrogenase E1 alpha (PDH-E1 ALPHA); FUNCTIONS IN: pyruvate dehydrogenase (acetyl-transferring) activity; INVOLVED IN: oxidation reduction, glycolysis, metabolic process; LOCATED IN: chloroplast, plastid, chloroplast envelope; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Dehydrogenase, E1 component (InterPro:IPR001017), Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit, subgroup y (InterPro:IPR017597); BEST Arabidopsis thaliana protein match is: pyruvate dehydrogenase complex E1 alpha subunit (TAIR:AT1G59900.1); Has 10065 Blast hits to 10059 proteins in 1888 species: Archae - 130; Bacteria - 6136; Metazoa - 517; Fungi - 241; Plants - 224; Viruses - 0; Other Eukaryotes - 2817 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    47234..49304 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_099991.4 → NP_171617.1  pyruvate dehydrogenase E1 alpha [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_171617.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O24457, Q9MAM6
    UniProtKB/TrEMBL
    A0A178W8A7, A0A5S9RZM7
    Conserved Domains (1) summary
    PLN02374
    Location:1 → 428
    PLN02374; pyruvate dehydrogenase (acetyl-transferring)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O24457.1

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