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TATDN1 TatD DNase domain containing 1 [ Homo sapiens (human) ]

Gene ID: 83940, updated on 3-Apr-2024

Summary

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Official Symbol
TATDN1provided by HGNC
Official Full Name
TatD DNase domain containing 1provided by HGNC
Primary source
HGNC:HGNC:24220
See related
Ensembl:ENSG00000147687 MIM:619364; AllianceGenome:HGNC:24220
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CDA11
Summary
Predicted to enable 3'-5'-exodeoxyribonuclease activity. Predicted to be involved in DNA metabolic process and nucleic acid phosphodiester bond hydrolysis. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 16.0), ovary (RPKM 13.3) and 25 other tissues See more
Orthologs
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Genomic context

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See TATDN1 in Genome Data Viewer
Location:
8q24.13
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (124488494..124539088, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (125621522..125672104, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (125500735..125551329, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:125483735-125484236 Neighboring gene RNF139 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27882 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:125486486-125487030 Neighboring gene tRNA methyltransferase 12 homolog Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:125487031-125487576 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:125487577-125488120 Neighboring gene ring finger protein 139 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27884 Neighboring gene microRNA 6844 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27885 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27886 Neighboring gene NADH:ubiquinone oxidoreductase subunit B9 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19514 Neighboring gene uncharacterized LOC105375740 Neighboring gene MTSS I-BAR domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. LncRNA TATDN1 contributes to the cisplatin resistance of non-small cell lung cancer through TATDN1/miR-451/TRIM66 axis. Wang L, et al. Cancer Biol Ther, 2019. PMID 30481109, Free PMC Article
  2. The role and potential mechanisms of LncRNA-TATDN1 on metastasis and invasion of non-small cell lung cancer. Zequn N, et al. Oncotarget, 2016 Apr 5. PMID 26943769, Free PMC Article
  3. Human and bacterial TatD enzymes exhibit apurinic/apyrimidinic (AP) endonuclease activity. Dorival J, et al. Nucleic Acids Res, 2023 Apr 11. PMID 36881763, Free PMC Article
  4. LncRNA TATDN1 induces the progression of hepatocellular carcinoma via targeting miRNA-6089. Shen C, et al. Eur Rev Med Pharmacol Sci, 2019 Aug. PMID 31378885
  5. The DNase domain-containing protein TATDN1 plays an important role in chromosomal segregation and cell cycle progression during zebrafish eye development. Yang H, et al. Cell Cycle, 2012 Dec 15. PMID 23187801, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Human and bacterial TatD enzymes exhibit apurinic/apyrimidinic (AP) endonuclease activity.
    Title: Human and bacterial TatD enzymes exhibit apurinic/apyrimidinic (AP) endonuclease activity.
  2. TATDN1 promotes the development and progression of breast cancer by targeting microRNA-140-3p.
    Title: TATDN1 promotes the development and progression of breast cancer by targeting microRNA-140-3p.
  3. LncRNA TATDN1 induces the progression of hepatocellular carcinoma via targeting miRNA-6089.
    Title: LncRNA TATDN1 induces the progression of hepatocellular carcinoma via targeting miRNA-6089.
  4. TATDN1 enhanced the DDP-tolerance of NSCLC cells by upregulating TRIM66 expression via sponging miR-451, hinting a novel regulatory pathway of chemoresistance in DDP-tolerant NSCLC cells.
    Title: LncRNA TATDN1 contributes to the cisplatin resistance of non-small cell lung cancer through TATDN1/miR-451/TRIM66 axis.
  5. The data indicate that TATDN1 expression is associated with 95D cells' higher potential of invasion and metastasis, and suggest that TATDN1 may be a potential prognostic factor and therapeutic target for non-small cell lung cancer.
    Title: The role and potential mechanisms of LncRNA-TATDN1 on metastasis and invasion of non-small cell lung cancer.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of TatD DNase domain containing 1 (TATDN1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ43280

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 3'-5'-DNA exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
deoxyribonuclease TATDN1
Names
hepatocarcinoma high expression protein
putative deoxyribonuclease TATDN1
NP_001139632.1
NP_001304818.1
NP_001304819.1
NP_001304820.1
NP_114415.1
XP_006716729.1
XP_006716732.1
XP_011515633.1
XP_016869384.1
XP_016869386.1
XP_016869388.1
XP_024303061.1
XP_047278256.1
XP_047278257.1
XP_047278258.1
XP_054189019.1
XP_054189020.1
XP_054189021.1
XP_054189022.1
XP_054189023.1
XP_054189024.1
XP_054189025.1
XP_054189026.1
XP_054189027.1
XP_054189028.1
XP_054217316.1
XP_054217317.1
XP_054217318.1
XP_054217319.1
XP_054217320.1
XP_054217321.1
XP_054217322.1
XP_054217323.1
XP_054217324.1
XP_054217325.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146160.1 → NP_001139632.1  deoxyribonuclease TATDN1 isoform b

    See identical proteins and their annotated locations for NP_001139632.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences compared to variant 4. These differences cause translation initiation at a downstream AUG and result in an isoform (b) that is shorter than isoform c.
    Source sequence(s)
    AF212250, AV729364, AY071865, BC007066
    Consensus CDS
    CCDS55273.1
    UniProtKB/Swiss-Prot
    Q6P1N9
    Related
    ENSP00000428336.1, ENST00000519548.5
    Conserved Domains (1) summary
    cd01310
    Location:1 → 247
    TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.

  2. NM_001317889.1 → NP_001304818.1  deoxyribonuclease TATDN1 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) encodes the longest isoform (c).
    Source sequence(s)
    AV729364, BC007066, BU784642, BX332564
    UniProtKB/TrEMBL
    E5RG17
    Related
    ENSP00000430274.1, ENST00000522810.5
    Conserved Domains (1) summary
    cd01310
    Location:6 → 330
    TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.

  3. NM_001317890.1 → NP_001304819.1  deoxyribonuclease TATDN1 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) has multiple differences compared to variant 4. These differences cause translation initiation at a downstream AUG and result in an isoform (d) that is shorter than isoform c.
    Source sequence(s)
    AV729364, AY071865, BC007066, BG532054
    Consensus CDS
    CCDS83323.1
    UniProtKB/TrEMBL
    A0A0D9SGD3, E5RGF2
    Related
    ENSP00000487380.1, ENST00000630259.1
    Conserved Domains (1) summary
    cd01310
    Location:14 → 240
    TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.

  4. NM_001317891.1 → NP_001304820.1  deoxyribonuclease TATDN1 isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) has multiple differences compared to variant 4. These differences cause translation initiation at a downstream AUG and result in an isoform (e) that is shorter than isoform c.
    Source sequence(s)
    AV729364, AY071865, BC007066, BG529611
    UniProtKB/Swiss-Prot
    Q6P1N9
    Conserved Domains (1) summary
    cl00281
    Location:1 → 149
    metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...

  5. NM_032026.4 → NP_114415.1  deoxyribonuclease TATDN1 isoform a

    See identical proteins and their annotated locations for NP_114415.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) uses an alternate in-frame splice site and lacks an alternate exon in the 3' coding region compared to variant 4. The encoded isoform (a) is shorter than isoform c.
    Source sequence(s)
    AF212250, AV729364, BC007066, BC064964
    Consensus CDS
    CCDS6351.1
    UniProtKB/Swiss-Prot
    B2R5J0, Q6P1N9, Q8TD02, Q9BY40
    UniProtKB/TrEMBL
    E5RG17
    Related
    ENSP00000276692.6, ENST00000276692.11
    Conserved Domains (1) summary
    cd01310
    Location:6 → 294
    TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.

RNA

  1. NR_027427.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in an internal exon compared to variant 4. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC090198, AF212250, AV729364, BC007066
    Related
    ENST00000523214.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    124488494..124539088 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011517331.4 → XP_011515633.1  deoxyribonuclease TATDN1 isoform X2

    UniProtKB/TrEMBL
    E5RG17
    Conserved Domains (1) summary
    cd01310
    Location:5 → 308
    TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.

  2. XM_024447293.2 → XP_024303061.1  deoxyribonuclease TATDN1 isoform X6

    UniProtKB/TrEMBL
    E5RG17
    Conserved Domains (1) summary
    cd01310
    Location:5 → 272
    TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.

  3. XM_006716666.5 → XP_006716729.1  deoxyribonuclease TATDN1 isoform X1

    UniProtKB/TrEMBL
    E5RG17
    Conserved Domains (1) summary
    cd01310
    Location:13 → 314
    TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.

  4. XM_017013895.3 → XP_016869384.1  deoxyribonuclease TATDN1 isoform X5

    UniProtKB/TrEMBL
    E5RG17

  5. XM_047422301.1 → XP_047278257.1  deoxyribonuclease TATDN1 isoform X4

  6. XM_006716669.4 → XP_006716732.1  deoxyribonuclease TATDN1 isoform X3

    See identical proteins and their annotated locations for XP_006716732.1

    UniProtKB/TrEMBL
    E5RG17
    Conserved Domains (1) summary
    cd01310
    Location:21 → 297
    TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.

  7. XM_047422302.1 → XP_047278258.1  deoxyribonuclease TATDN1 isoform X9

  8. XM_047422300.1 → XP_047278256.1  deoxyribonuclease TATDN1 isoform X3

  9. XM_017013897.3 → XP_016869386.1  deoxyribonuclease TATDN1 isoform X7

    Conserved Domains (1) summary
    cd01310
    Location:21 → 261
    TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.

  10. XM_017013899.2 → XP_016869388.1  deoxyribonuclease TATDN1 isoform X8

    UniProtKB/TrEMBL
    G5EA19
    Related
    ENSP00000476180.1, ENST00000605953.5

RNA

  1. XR_007060756.1 RNA Sequence

    Related
    ENST00000519776.5

  2. XR_007060757.1 RNA Sequence

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791784.1 Reference GRCh38.p14 PATCHES

    Range
    23444..74038 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054333045.1 → XP_054189020.1  deoxyribonuclease TATDN1 isoform X2

  2. XM_054333050.1 → XP_054189025.1  deoxyribonuclease TATDN1 isoform X6

  3. XM_054333044.1 → XP_054189019.1  deoxyribonuclease TATDN1 isoform X1

  4. XM_054333049.1 → XP_054189024.1  deoxyribonuclease TATDN1 isoform X5

  5. XM_054333048.1 → XP_054189023.1  deoxyribonuclease TATDN1 isoform X4

  6. XM_054333047.1 → XP_054189022.1  deoxyribonuclease TATDN1 isoform X3

  7. XM_054333053.1 → XP_054189028.1  deoxyribonuclease TATDN1 isoform X9

  8. XM_054333046.1 → XP_054189021.1  deoxyribonuclease TATDN1 isoform X3

  9. XM_054333051.1 → XP_054189026.1  deoxyribonuclease TATDN1 isoform X7

  10. XM_054333052.1 → XP_054189027.1  deoxyribonuclease TATDN1 isoform X8

RNA

  1. XR_008485817.1 RNA Sequence

  2. XR_008485818.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    125621522..125672104 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054361342.1 → XP_054217317.1  deoxyribonuclease TATDN1 isoform X2

  2. XM_054361347.1 → XP_054217322.1  deoxyribonuclease TATDN1 isoform X6

  3. XM_054361341.1 → XP_054217316.1  deoxyribonuclease TATDN1 isoform X1

  4. XM_054361346.1 → XP_054217321.1  deoxyribonuclease TATDN1 isoform X5

  5. XM_054361345.1 → XP_054217320.1  deoxyribonuclease TATDN1 isoform X4

  6. XM_054361344.1 → XP_054217319.1  deoxyribonuclease TATDN1 isoform X3

  7. XM_054361350.1 → XP_054217325.1  deoxyribonuclease TATDN1 isoform X9

  8. XM_054361343.1 → XP_054217318.1  deoxyribonuclease TATDN1 isoform X3

  9. XM_054361348.1 → XP_054217323.1  deoxyribonuclease TATDN1 isoform X7

  10. XM_054361349.1 → XP_054217324.1  deoxyribonuclease TATDN1 isoform X8

RNA

  1. XR_008487883.1 RNA Sequence

  2. XR_008487884.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P1N9.2 GenPept UniProtKB/Swiss-Prot:Q6P1N9

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