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HDG2 homeodomain GLABROUS 2 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 839256, updated on 18-Sep-2024

Summary

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Official Symbol
HDG2
Official Full Name
homeodomain GLABROUS 2
Primary source
TAIR:AT1G05230
Locus tag
AT1G05230
See related
Araport:AT1G05230
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
homeodomain GLABROUS 2; YUP8H12.16; YUP8H12_16
Summary
Encodes a homeobox-leucine zipper family protein belonging to the HD-ZIP IV family. Mutants have trichomes that appear glass-like under a dissecting microscope as compared to the wild-type trichomes. The mutations do not affect trichome growth or branch number.
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Genomic context

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See HDG2 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
14
Sequence:
Chromosome: 1; NC_003070.9 (1512896..1518900, complement)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Transmembrane protein 97, Putative Neighboring gene Transmembrane protein 97, Putative Neighboring gene ncRNA Neighboring gene Peroxidase superfamily protein Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. HOMEODOMAIN GLABROUS2 regulates cellulose biosynthesis in seed coat mucilage by activating CELLULOSE SYNTHASE5. Kong Y, et al. Plant Physiol, 2021 Feb 25. PMID 33631797, Free PMC Article
  2. Arabidopsis homeodomain-leucine zipper IV proteins promote stomatal development and ectopically induce stomata beyond the epidermis. Peterson KM, et al. Development, 2013 May. PMID 23515473, Free PMC Article
  3. Mutations in epidermis-specific HD-ZIP IV genes affect floral organ identity in Arabidopsis thaliana. Kamata N, et al. Plant J, 2013 Aug. PMID 23590515
  4. Transcriptome analysis of Arabidopsis wild-type and gl3-sst sim trichomes identifies four additional genes required for trichome development. Marks MD, et al. Mol Plant, 2009 Jul. PMID 19626137, Free PMC Article
  5. AIL and HDG proteins act antagonistically to control cell proliferation. Horstman A, et al. Development, 2015 Feb 1. PMID 25564655

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. HDG2 is involved in determining the identity of petals and stamens.
    Title: Mutations in epidermis-specific HD-ZIP IV genes affect floral organ identity in Arabidopsis thaliana.
  2. HDG2 overexpression confers differentiation of ectopic stomata in internal mesophyll tissues.
    Title: Arabidopsis homeodomain-leucine zipper IV proteins promote stomatal development and ectopically induce stomata beyond the epidermis.
  3. HDG2 gene is required for normal gl3-sst sim trichome development.
    Title: Transcriptome analysis of Arabidopsis wild-type and gl3-sst sim trichomes identifies four additional genes required for trichome development.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001123759.1
NM_001197982.1
NM_001331528.1
NM_001331529.1
NM_001331530.1
NM_001331531.1
NM_001331532.1
NM_001331533.1
NM_001331534.1
NM_001331535.1
NM_100402.3
NM_179265.2

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription cis-regulatory region binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within maintenance of floral organ identity IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in maintenance of floral organ identity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mucilage biosynthetic process involved in seed coat development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in plant-type cell wall cellulose metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription initiation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within seed coat development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within trichome morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
homeodomain GLABROUS 2
NP_001117231.1
  • homeodomain GLABROUS 2 (HDG2); FUNCTIONS IN: DNA binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: regulation of transcription, DNA-dependent, trichome morphogenesis; LOCATED IN: nucleus; EXPRESSED IN: 32 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Homeobox, conserved site (InterPro:IPR017970), Homeobox (InterPro:IPR001356), Homeodomain-like (InterPro:IPR009057), Lipid-binding START (InterPro:IPR002913), Homeodomain-related (InterPro:IPR012287); BEST Arabidopsis thaliana protein match is: protodermal factor 2 (TAIR:AT4G04890.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
NP_001184911.1
  • homeodomain GLABROUS 2 (HDG2); FUNCTIONS IN: DNA binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: regulation of transcription, DNA-dependent, trichome morphogenesis; LOCATED IN: nucleus; EXPRESSED IN: 32 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Homeobox, conserved site (InterPro:IPR017970), Homeobox (InterPro:IPR001356), Homeodomain-like (InterPro:IPR009057), Lipid-binding START (InterPro:IPR002913), Homeodomain-related (InterPro:IPR012287); BEST Arabidopsis thaliana protein match is: protodermal factor 2 (TAIR:AT4G04890.1).
NP_172015.1
  • homeodomain GLABROUS 2 (HDG2); FUNCTIONS IN: DNA binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: regulation of transcription, DNA-dependent, trichome morphogenesis; LOCATED IN: nucleus; EXPRESSED IN: 32 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Homeobox, conserved site (InterPro:IPR017970), Homeobox (InterPro:IPR001356), Homeodomain-like (InterPro:IPR009057), Lipid-binding START (InterPro:IPR002913), Homeodomain-related (InterPro:IPR012287); BEST Arabidopsis thaliana protein match is: protodermal factor 2 (TAIR:AT4G04890.1); Has 8730 Blast hits to 8651 proteins in 460 species: Archae - 0; Bacteria - 0; Metazoa - 6110; Fungi - 222; Plants - 2153; Viruses - 0; Other Eukaryotes - 245 (source: NCBI BLink).
NP_849596.1
  • homeodomain GLABROUS 2 (HDG2); FUNCTIONS IN: DNA binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: regulation of transcription, DNA-dependent, trichome morphogenesis; LOCATED IN: nucleus; EXPRESSED IN: 32 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Homeobox, conserved site (InterPro:IPR017970), Homeobox (InterPro:IPR001356), Homeodomain-like (InterPro:IPR009057), Lipid-binding START (InterPro:IPR002913), Homeodomain-related (InterPro:IPR012287); BEST Arabidopsis thaliana protein match is: protodermal factor 2 (TAIR:AT4G04890.1); Has 8732 Blast hits to 8653 proteins in 460 species: Archae - 0; Bacteria - 0; Metazoa - 6111; Fungi - 223; Plants - 2153; Viruses - 0; Other Eukaryotes - 245 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    1512896..1518900 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001123759.1 → NP_001117231.1  homeodomain GLABROUS 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001117231.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178WDY9, B3H6Y4
    Conserved Domains (3) summary
    cd08875
    Location:246 → 464
    START_ArGLABRA2_like; C-terminal lipid-binding START domain of the Arabidopsis homeobox protein GLABRA 2 and related proteins
    pfam00046
    Location:67 → 120
    Homeobox; Homeobox domain
    cl19252
    Location:130 → 202
    MreC; rod shape-determining protein MreC

  2. NM_179265.2 → NP_849596.1  homeodomain GLABROUS 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_849596.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O23045, Q94C37
    UniProtKB/TrEMBL
    A0A178WE21, A0A5S9SPD3, B9DFH8
    Conserved Domains (2) summary
    cd08875
    Location:246 → 464
    START_ArGLABRA2_like; C-terminal lipid-binding START domain of the Arabidopsis homeobox protein GLABRA 2 and related proteins
    pfam00046
    Location:67 → 121
    Homeobox; Homeobox domain

  3. NM_001197982.1 → NP_001184911.1  homeodomain GLABROUS 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001184911.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O23045, Q94C37
    UniProtKB/TrEMBL
    A0A178WE21, A0A5S9SPD3, B9DFH8
    Conserved Domains (2) summary
    cd08875
    Location:246 → 464
    START_ArGLABRA2_like; C-terminal lipid-binding START domain of the Arabidopsis homeobox protein GLABRA 2 and related proteins
    pfam00046
    Location:67 → 121
    Homeobox; Homeobox domain

  4. NM_100402.3 → NP_172015.1  homeodomain GLABROUS 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_172015.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O23045, Q94C37
    UniProtKB/TrEMBL
    A0A178WE21, A0A5S9SPD3, B9DFH8
    Conserved Domains (2) summary
    cd08875
    Location:246 → 464
    START_ArGLABRA2_like; C-terminal lipid-binding START domain of the Arabidopsis homeobox protein GLABRA 2 and related proteins
    pfam00046
    Location:67 → 121
    Homeobox; Homeobox domain

  5. NM_001331528.1 → NP_001322680.1  homeodomain GLABROUS 2 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O23045, Q94C37
    UniProtKB/TrEMBL
    A0A178WE21, A0A5S9SPD3, B9DFH8
    Conserved Domains (2) summary
    cd08875
    Location:246 → 464
    START_ArGLABRA2_like; C-terminal lipid-binding START domain of the Arabidopsis homeobox protein GLABRA 2 and related proteins
    pfam00046
    Location:67 → 121
    Homeobox; Homeobox domain

  6. NM_001331533.1 → NP_001322675.1  homeodomain GLABROUS 2 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O23045, Q94C37
    UniProtKB/TrEMBL
    A0A178WE21, A0A5S9SPD3, B9DFH8
    Conserved Domains (2) summary
    cd08875
    Location:246 → 464
    START_ArGLABRA2_like; C-terminal lipid-binding START domain of the Arabidopsis homeobox protein GLABRA 2 and related proteins
    pfam00046
    Location:67 → 121
    Homeobox; Homeobox domain

  7. NM_001331532.1 → NP_001322674.1  homeodomain GLABROUS 2 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O23045, Q94C37
    UniProtKB/TrEMBL
    A0A178WE21, A0A5S9SPD3, B9DFH8
    Conserved Domains (2) summary
    cd08875
    Location:246 → 464
    START_ArGLABRA2_like; C-terminal lipid-binding START domain of the Arabidopsis homeobox protein GLABRA 2 and related proteins
    pfam00046
    Location:67 → 121
    Homeobox; Homeobox domain

  8. NM_001331531.1 → NP_001322673.1  homeodomain GLABROUS 2 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O23045, Q94C37
    UniProtKB/TrEMBL
    A0A178WE21, A0A5S9SPD3, B9DFH8
    Conserved Domains (2) summary
    cd08875
    Location:246 → 464
    START_ArGLABRA2_like; C-terminal lipid-binding START domain of the Arabidopsis homeobox protein GLABRA 2 and related proteins
    pfam00046
    Location:67 → 121
    Homeobox; Homeobox domain

  9. NM_001331529.1 → NP_001322678.1  homeodomain GLABROUS 2 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O23045, Q94C37
    UniProtKB/TrEMBL
    A0A178WE21, A0A5S9SPD3, B9DFH8
    Conserved Domains (2) summary
    cd08875
    Location:246 → 464
    START_ArGLABRA2_like; C-terminal lipid-binding START domain of the Arabidopsis homeobox protein GLABRA 2 and related proteins
    pfam00046
    Location:67 → 121
    Homeobox; Homeobox domain

  10. NM_001331535.1 → NP_001322677.1  homeodomain GLABROUS 2 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O23045, Q94C37
    UniProtKB/TrEMBL
    A0A178WE21, A0A5S9SPD3, B9DFH8
    Conserved Domains (2) summary
    cd08875
    Location:246 → 464
    START_ArGLABRA2_like; C-terminal lipid-binding START domain of the Arabidopsis homeobox protein GLABRA 2 and related proteins
    pfam00046
    Location:67 → 121
    Homeobox; Homeobox domain

  11. NM_001331534.1 → NP_001322676.1  homeodomain GLABROUS 2 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O23045, Q94C37
    UniProtKB/TrEMBL
    A0A178WE21, A0A5S9SPD3, B9DFH8
    Conserved Domains (2) summary
    cd08875
    Location:246 → 464
    START_ArGLABRA2_like; C-terminal lipid-binding START domain of the Arabidopsis homeobox protein GLABRA 2 and related proteins
    pfam00046
    Location:67 → 121
    Homeobox; Homeobox domain

  12. NM_001331530.1 → NP_001322679.1  homeodomain GLABROUS 2 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178WE21, A0A1P8AUV2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q94C37.1

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