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IAR4 thiamine diphosphate-binding fold (THDP-binding) superfamily protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 839031, updated on 18-Sep-2024

Summary

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Official Symbol
IAR4
Official Full Name
thiamine diphosphate-binding fold (THDP-binding) superfamily protein
Primary source
TAIR:AT1G24180
Locus tag
AT1G24180
See related
Araport:AT1G24180
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
F3I6.11; F3I6_11; IAA-CONJUGATE-RESISTANT 4
Summary
Arabidopsis thaliana pyruvate dehydrogenase E1a-like subunit. 81% identical to a previously characterized Arabidopsis mitochondrial PDH E1a-subunit, At1g59900. Serine 296 phosphorylation of IAR4 has critical function in root hair formation and root development. Changing Ser296 in IAR4 to Ala resulted in a phenotype intermediate between mutant and wild-type, while substitution to Asp was either lethal or caused an extreme dwarf phenotype.
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Genomic context

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See IAR4 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
8
Sequence:
Chromosome: 1; NC_003070.9 (8560420..8563502, complement)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Interleukin-1 receptor-associated kinase 4 protein Neighboring gene triadin Neighboring gene Nucleotide-diphospho-sugar transferases superfamily protein Neighboring gene SIN3-like 3 Neighboring gene Paired amphipathic helix (PAH2) superfamily protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Arabidopsis IAR4 modulates auxin response by regulating auxin homeostasis. Quint M, et al. Plant Physiol, 2009 Jun. PMID 19395411, Free PMC Article
  2. Heterogeneity of the mitochondrial proteome for photosynthetic and non-photosynthetic Arabidopsis metabolism. Lee CP, et al. Mol Cell Proteomics, 2008 Jul. PMID 18385124
  3. The Extra-Pathway Interactome of the TCA Cycle: Expected and Unexpected Metabolic Interactions. Zhang Y, et al. Plant Physiol, 2018 Jul. PMID 29794018, Free PMC Article
  4. Analysis of the Arabidopsis mitochondrial proteome. Millar AH, et al. Plant Physiol, 2001 Dec. PMID 11743115, Free PMC Article
  5. Divalent metal ions in plant mitochondria and their role in interactions with proteins and oxidative stress-induced damage to respiratory function. Tan YF, et al. Plant Physiol, 2010 Feb. PMID 20018591, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The auxin phenotypes of iar4 mutants are the result of altered indole-3-acetic acid homeostasis.
    Title: Arabidopsis IAR4 modulates auxin response by regulating auxin homeostasis.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_102264.5

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables cobalt ion binding HDA PubMed 
enables pyruvate dehydrogenase (acetyl-transferring) activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding HDA PubMed 
Process Evidence Code Pubs
involved_in acetyl-CoA biosynthetic process from pyruvate IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in cytosol HDA PubMed 
located_in mitochondrion HDA PubMed 
located_in nucleus HDA PubMed 

General protein information

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Preferred Names
thiamine diphosphate-binding fold (THDP-binding) superfamily protein
NP_173828.1
  • IAA-CONJUGATE-RESISTANT 4 (IAR4); FUNCTIONS IN: cobalt ion binding, pyruvate dehydrogenase (acetyl-transferring) activity, zinc ion binding; INVOLVED IN: response to salt stress, metabolic process; LOCATED IN: cytosol, mitochondrion, nucleus; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Dehydrogenase, E1 component (InterPro:IPR001017), Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit, subgroup y (InterPro:IPR017597); BEST Arabidopsis thaliana protein match is: pyruvate dehydrogenase complex E1 alpha subunit (TAIR:AT1G59900.1); Has 9959 Blast hits to 9956 proteins in 1842 species: Archae - 124; Bacteria - 6117; Metazoa - 560; Fungi - 255; Plants - 209; Viruses - 0; Other Eukaryotes - 2694 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    8560420..8563502 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_102264.5 → NP_173828.1  thiamine diphosphate-binding fold (THDP-binding) superfamily protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_173828.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O48685, Q8H1Y0
    UniProtKB/TrEMBL
    A0A178WAC1, A0A5S9VTJ7
    Conserved Domains (1) summary
    PLN02269
    Location:32 → 393
    PLN02269; Pyruvate dehydrogenase E1 component subunit alpha
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8H1Y0.2

Gene LinkOut

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