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BSU1 Serine/threonine protein phosphatase family protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 838804, updated on 18-Sep-2024

Summary

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Official Symbol
BSU1
Official Full Name
Serine/threonine protein phosphatase family protein
Primary source
TAIR:AT1G03445
Locus tag
AT1G03445
See related
Araport:AT1G03445
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
BRI1 SUPPRESSOR 1; F21B7.7
Summary
encodes a serine#Aeithreonine protein phosphatase with an N-terminal Kelch-repeat domain, which is nuclear localized and expressed preferentially in elongating cells. Genetic evidence suggest that this gene plays a redundant role (along with other members of the same gene family) in modulating growth in response to brassinosteroid.
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Genomic context

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See BSU1 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
22
Sequence:
Chromosome: 1; NC_003070.9 (854410..859701, complement)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene histidine-containing phosphotransfer factor 5 Neighboring gene Leucine-rich repeat (LRR) family protein Neighboring gene RNA-binding (RRM/RBD/RNP motifs) family protein Neighboring gene Kinase interacting (KIP1-like) family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Nuclear protein phosphatases with Kelch-repeat domains modulate the response to brassinosteroids in Arabidopsis. Mora-García S, et al. Genes Dev, 2004 Feb 15. PMID 14977918, Free PMC Article
  2. BRASSINOSTEROID-SIGNALING KINASE 3, a plasma membrane-associated scaffold protein involved in early brassinosteroid signaling. Ren H, et al. PLoS Genet, 2019 Jan. PMID 30615605, Free PMC Article
  3. Predominant actions of cytosolic BSU1 and nuclear BIN2 regulate subcellular localization of BES1 in brassinosteroid signaling. Ryu H, et al. Mol Cells, 2010 Mar. PMID 20387035
  4. The CDG1 kinase mediates brassinosteroid signal transduction from BRI1 receptor kinase to BSU1 phosphatase and GSK3-like kinase BIN2. Kim TW, et al. Mol Cell, 2011 Aug 19. PMID 21855796, Free PMC Article
  5. Nucleocytoplasmic shuttling of BZR1 mediated by phosphorylation is essential in Arabidopsis brassinosteroid signaling. Ryu H, et al. Plant Cell, 2007 Sep. PMID 17873094, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. we find that BSK3 upregulates BSU1 transcript and protein levels to activate BR signaling. BSK3 is broadly expressed and plays an important role in BR-mediated root growth, shoot growth, and organ separation. Together, our findings suggest that BSK3 may function as a scaffold protein to regulate BR signaling. The results of our studies provide new insights into early BR signaling mechanisms.
    Title: BRASSINOSTEROID-SIGNALING KINASE 3, a plasma membrane-associated scaffold protein involved in early brassinosteroid signaling.
  2. Cytoplasmic BSU1 mediated BES1 dephosphorylation & nuclear translocation, & it compromised the dwarf phenotype of bri1-5 better than nuclear BSU1 in transgenic plants.
    Title: Predominant actions of cytosolic BSU1 and nuclear BIN2 regulate subcellular localization of BES1 in brassinosteroid signaling.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in brassinosteroid mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within brassinosteroid mediated signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of brassinosteroid mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of protein localization IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Serine/threonine protein phosphatase family protein
NP_171844.6
  • BRI1 SUPPRESSOR 1 (BSU1); FUNCTIONS IN: protein binding, protein serine/threonine phosphatase activity; INVOLVED IN: brassinosteroid mediated signaling pathway, regulation of protein localization; LOCATED IN: nucleus; EXPRESSED IN: sperm cell, male gametophyte, cultured cell, pollen tube; EXPRESSED DURING: L mature pollen stage, M germinated pollen stage; CONTAINS InterPro DOMAIN/s: Serine/threonine protein phosphatase, BSU1 (InterPro:IPR012391), Galactose oxidase/kelch, beta-propeller (InterPro:IPR011043), Metallophosphoesterase (InterPro:IPR004843), Kelch repeat type 2 (InterPro:IPR011498), Kelch-type beta propeller (InterPro:IPR015915), Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase (InterPro:IPR006186); BEST Arabidopsis thaliana protein match is: BRI1 suppressor 1 (BSU1)-like 1 (TAIR:AT4G03080.1); Has 12351 Blast hits to 9811 proteins in 679 species: Archae - 82; Bacteria - 604; Metazoa - 4121; Fungi - 2161; Plants - 2580; Viruses - 7; Other Eukaryotes - 2796 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    854410..859701 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_100227.6 → NP_171844.6  Serine/threonine protein phosphatase family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_171844.6

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9LR78
    UniProtKB/TrEMBL
    A0A178WIX8, A0A5S9SDH6
    Conserved Domains (3) summary
    PLN02193
    Location:26 → 294
    PLN02193; nitrile-specifier protein
    sd00038
    Location:31 → 92
    Kelch; KELCH repeat [structural motif]
    cl13995
    Location:456 → 757
    MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain

  2. NM_001331412.1 → NP_001321215.1  Serine/threonine protein phosphatase family protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8AQ82, A0A5S9SDH6
    Conserved Domains (3) summary
    PLN02193
    Location:26 → 294
    PLN02193; nitrile-specifier protein
    sd00038
    Location:31 → 92
    Kelch; KELCH repeat [structural motif]
    cl13995
    Location:456 → 757
    MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9LR78.2

Gene LinkOut

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