PIP5K1 phosphatidylinositol-4-phosphate 5-kinase 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: PIP5K1
Official Full Name: phosphatidylinositol-4-phosphate 5-kinase 1
Primary source: TAIR:AT1G21980
Locus tag: AT1G21980
See related: Araport:AT1G21980
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATPIP5K1; ATPIPK1; PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE; phosphatidylinositol-4-phosphate 5-kinase 1
Summary: Type I phosphatidylinositol-4-phosphate 5-kinase. Preferentially phosphorylates PtdIns4P. Induced by water stress and abscisic acid in Arabidopsis thaliana. Expressed in procambial cells of leaves, flowers and roots. A N-terminal Membrane Occupation and Recognition Nexus (MORN)affects enzyme activity and distribution.
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Genomic context

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See PIP5K1 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 8

Sequence:: Chromosome: 1; NC_003070.9 (7734661..7738772)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PIP5K1 and PIP5K2 are expressed during early stages of pollen development and their transcriptional activity respond to auxin in pollen grains. PIP5K1, PIP5K2 and phosphoinositide signaling are important cues for early developmental stages and vacuole formation during microgametogenesis.
Title: Phosphatidylinositol 4-phosphate 5-kinases 1 and 2 are involved in the regulation of vacuole morphology during Arabidopsis thaliana pollen development.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_102047.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables actin filament binding	IDA Inferred from Direct Assay more info	PubMed
enables actin monomer binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol kinase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in phosphatidylinositol metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphatidylinositol phosphate biosynthetic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISM Inferred from Sequence Model more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: phosphatidylinositol-4-phosphate 5-kinase 1

NP_173617.1

phosphatidylinositol-4-phosphate 5-kinase 1 (PIP5K1); CONTAINS InterPro DOMAIN/s: Phosphatidylinositol-4-phosphate 5-kinase, core, subgroup (InterPro:IPR016034), Phosphatidylinositol-4-phosphate 5-kinase, plant (InterPro:IPR017163), MORN motif (InterPro:IPR003409), Phosphatidylinositol-4-phosphate 5-kinase, core (InterPro:IPR002498); BEST Arabidopsis thaliana protein match is: phosphatidylinositol-4-phosphate 5-kinase 2 (TAIR:AT1G77740.1); Has 28574 Blast hits to 7954 proteins in 630 species: Archae - 0; Bacteria - 3995; Metazoa - 4425; Fungi - 453; Plants - 2526; Viruses - 0; Other Eukaryotes - 17175 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

7734661..7738772

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_102047.4 → NP_173617.1 phosphatidylinositol-4-phosphate 5-kinase 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_173617.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O22503, O82120, Q56YP2, Q9LM65

UniProtKB/TrEMBL

A0A178W750, A0A5S9VGU1

Conserved Domains (1) summary

PLN03185
Location:72 → 748

PLN03185; phosphatidylinositol phosphate kinase; Provisional