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MCCA methylcrotonyl-CoA carboxylase alpha chain [ Arabidopsis thaliana (thale cress) ]

Gene ID: 838362, updated on 18-Sep-2024

Summary

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Official Symbol
MCCA
Official Full Name
methylcrotonyl-CoA carboxylase alpha chain
Primary source
TAIR:AT1G03090
Locus tag
AT1G03090
See related
Araport:AT1G03090
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Summary
MCCA is the biotinylated subunit of the dimer MCCase, which is involved in leucine degradation. Both subunits are nuclear coded and the active enzyme is located in the mitochondrion.
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Genomic context

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See MCCA in Genome Data Viewer
Location:
chromosome: 1
Exon count:
16
Sequence:
Chromosome: 1; NC_003070.9 (739544..744184)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene BEACH-DOMAIN HOMOLOG A1 Neighboring gene Bax inhibitor-1 family protein Neighboring gene kinase interacting (KIP1-like) family protein Neighboring gene ncRNA Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein Neighboring gene ncRNA Neighboring gene Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic dissection of methylcrotonyl CoA carboxylase indicates a complex role for mitochondrial leucine catabolism during seed development and germination. Ding G, et al. Plant J, 2012 May. PMID 22211474
  2. Metabolic and environmental regulation of 3-methylcrotonyl-coenzyme A carboxylase expression in Arabidopsis. Che P, et al. Plant Physiol, 2002 Jun. PMID 12068107, Free PMC Article
  3. Heterogeneity of the mitochondrial proteome for photosynthetic and non-photosynthetic Arabidopsis metabolism. Lee CP, et al. Mol Cell Proteomics, 2008 Jul. PMID 18385124
  4. High heterogeneity within the ribosomal proteins of the Arabidopsis thaliana 80S ribosome. Giavalisco P, et al. Plant Mol Biol, 2005 Mar. PMID 15821981
  5. Divalent metal ions in plant mitochondria and their role in interactions with proteins and oxidative stress-induced damage to respiratory function. Tan YF, et al. Plant Physiol, 2010 Feb. PMID 20018591, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Studies indicate that mutations in either 3-methylcrotonyl CoA carboxylase MCCA (At1g03090) or MCCB (At4g34030) block mitochondrial Leu catabolism, as inferred from the increased accumulation of Leu.
    Title: Genetic dissection of methylcrotonyl CoA carboxylase indicates a complex role for mitochondrial leucine catabolism during seed development and germination.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_100191.4
NM_179252.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables cobalt ion binding HDA PubMed 
enables methylcrotonoyl-CoA carboxylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within L-leucine catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in L-leucine catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosolic ribosome HDA PubMed 
located_in extracellular region HDA PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
methylcrotonyl-CoA carboxylase alpha chain
NP_563674.1
  • MCCA; FUNCTIONS IN: cobalt ion binding, methylcrotonoyl-CoA carboxylase activity; INVOLVED IN: leucine catabolic process; LOCATED IN: mitochondrion, cytosolic ribosome; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Single hybrid motif (InterPro:IPR011053), Biotin/lipoyl attachment (InterPro:IPR000089), Carbamoyl phosphate synthase, large subunit, N-terminal (InterPro:IPR005481), Carbamoyl phosphate synthetase, large subunit, ATP-binding (InterPro:IPR005479), PreATP-grasp-like fold (InterPro:IPR016185), Biotin-binding site (InterPro:IPR001882), Biotin carboxylation domain (InterPro:IPR011764), Biotin carboxylase, C-terminal (InterPro:IPR005482), ATP-grasp fold (InterPro:IPR011761), ATP-grasp fold, subdomain 2 (InterPro:IPR013816), Rudiment single hybrid motif (InterPro:IPR011054), Pre-ATP-grasp fold (InterPro:IPR013817); BEST Arabidopsis thaliana protein match is: acetyl Co-enzyme a carboxylase biotin carboxylase subunit (TAIR:AT5G35360.1); Has 35200 Blast hits to 30603 proteins in 3073 species: Archae - 603; Bacteria - 22615; Metazoa - 922; Fungi - 892; Plants - 784; Viruses - 0; Other Eukaryotes - 9384 (source: NCBI BLink).
NP_849583.1
  • MCCA; FUNCTIONS IN: cobalt ion binding, methylcrotonoyl-CoA carboxylase activity; INVOLVED IN: leucine catabolic process; LOCATED IN: mitochondrion, cytosolic ribosome; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Single hybrid motif (InterPro:IPR011053), Biotin/lipoyl attachment (InterPro:IPR000089), Carbamoyl phosphate synthase, large subunit, N-terminal (InterPro:IPR005481), Carbamoyl phosphate synthetase, large subunit, ATP-binding (InterPro:IPR005479), PreATP-grasp-like fold (InterPro:IPR016185), Biotin-binding site (InterPro:IPR001882), Biotin carboxylation domain (InterPro:IPR011764), Biotin carboxylase, C-terminal (InterPro:IPR005482), ATP-grasp fold (InterPro:IPR011761), ATP-grasp fold, subdomain 2 (InterPro:IPR013816), Rudiment single hybrid motif (InterPro:IPR011054), Pre-ATP-grasp fold (InterPro:IPR013817); BEST Arabidopsis thaliana protein match is: acetyl Co-enzyme a carboxylase biotin carboxylase subunit (TAIR:AT5G35360.1); Has 41492 Blast hits to 34824 proteins in 3674 species: Archae - 718; Bacteria - 26555; Metazoa - 1797; Fungi - 1117; Plants - 802; Viruses - 0; Other Eukaryotes - 10503 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    739544..744184
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_179252.3 → NP_849583.1  methylcrotonyl-CoA carboxylase alpha chain [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_849583.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q42523, Q9SA61
    UniProtKB/TrEMBL
    A0A654E6B5, A0A7G2DQ98
    Conserved Domains (1) summary
    COG4770
    Location:38 → 734
    PccA; Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid transport and metabolism]

  2. NM_100191.4 → NP_563674.1  methylcrotonyl-CoA carboxylase alpha chain [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_563674.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A7G2DQ98
    Conserved Domains (5) summary
    cd06850
    Location:646 → 712
    biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...
    COG4770
    Location:38 → 714
    PccA; Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid transport and metabolism]
    pfam00289
    Location:38 → 146
    CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
    pfam02785
    Location:353 → 460
    Biotin_carb_C; Biotin carboxylase C-terminal domain
    cl17255
    Location:151 → 339
    ATP-grasp_4; ATP-grasp domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q42523.2

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