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HYL1 dsRNA-binding domain-like superfamily protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 837498, updated on 18-Sep-2024

Summary

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Official Symbol
HYL1
Official Full Name
dsRNA-binding domain-like superfamily protein
Primary source
TAIR:AT1G09700
Locus tag
AT1G09700
See related
Araport:AT1G09700
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
AtDRB1; DRB1; DSRNA-BINDING PROTEIN 1; F21M12.9; F21M12_9; HYPONASTIC LEAVES 1
Summary
Encodes a nuclear dsRNA binding protein. Involved in mRNA cleavage. The mutant is characterized by shorter stature, delayed flowering, leaf hyponasty, reduced fertility, decreased rate of root growth, and an altered root gravitropic response. It also exhibits less sensitivity to auxin and cytokinin.
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Genomic context

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See HYL1 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
3
Sequence:
Chromosome: 1; NC_003070.9 (3137649..3140353, complement)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Toll-Interleukin-Resistance (TIR) domain family protein Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein Neighboring gene Translation protein SH3-like family protein Neighboring gene Homeodomain-like superfamily protein Neighboring gene Kinase interacting (KIP1-like) family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Solution structure and behaviour of the Arabidopsis thaliana HYL1 protein. Wieczorek P, et al. Biochim Biophys Acta Gen Subj, 2023 Aug. PMID 37150226
  2. A mutation in the Arabidopsis HYL1 gene encoding a dsRNA binding protein affects responses to abscisic acid, auxin, and cytokinin. Lu C, et al. Plant Cell, 2000 Dec. PMID 11148283, Free PMC Article
  3. The nuclear dsRNA binding protein HYL1 is required for microRNA accumulation and plant development, but not posttranscriptional transgene silencing. Vazquez F, et al. Curr Biol, 2004 Feb 17. PMID 14972688
  4. The N-terminal double-stranded RNA binding domains of Arabidopsis HYPONASTIC LEAVES1 are sufficient for pre-microRNA processing. Wu F, et al. Plant Cell, 2007 Mar. PMID 17337628, Free PMC Article
  5. Gene structures and processing of Arabidopsis thaliana HYL1-dependent pri-miRNAs. Szarzynska B, et al. Nucleic Acids Res, 2009 May. PMID 19304749, Free PMC Article

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Solution structure and behaviour of the Arabidopsis thaliana HYL1 protein.
    Title: Solution structure and behaviour of the Arabidopsis thaliana HYL1 protein.
  2. HYPONASTIC LEAVES 1 is required for proper establishment of auxin gradient in apical hooks.
    Title: HYPONASTIC LEAVES 1 is required for proper establishment of auxin gradient in apical hooks.
  3. Cytoplasmic HYL1 modulates miRNA-mediated translational repression.
    Title: Cytoplasmic HYL1 modulates miRNA-mediated translational repression.
  4. Light-stabilized FHA2 suppresses miRNA biogenesis through interactions with DCL1 and HYL1.
    Title: Light-stabilized FHA2 suppresses miRNA biogenesis through interactions with DCL1 and HYL1.
  5. The Intrinsically Disordered Protein CARP9 Bridges HYL1 to AGO1 in the Nucleus to Promote MicroRNA Activity.
    Title: The Intrinsically Disordered Protein CARP9 Bridges HYL1 to AGO1 in the Nucleus to Promote MicroRNA Activity.
  6. Dual function of HYPONASTIC LEAVES 1 during early skotomorphogenic growth in Arabidopsis.
    Title: Dual function of HYPONASTIC LEAVES 1 during early skotomorphogenic growth in Arabidopsis.
  7. Hyponastic Leaves 1 protects pri-miRNAs from nuclear exosome attack.
    Title: Hyponastic Leaves 1 protects pri-miRNAs from nuclear exosome attack.
  8. The selection of these GC signatures was dependent on an RNA binding protein partner of DCL1 named HYL1.
    Title: A conserved sequence signature is essential for robust plant miRNA biogenesis.
  9. The transcriptional response of select ER stress-responsive genes in hyl1 mutant plants was indistinguishable from that of wild-type plants, suggesting that the loss-of-function of HYL1 does not affect the ER stress signaling pathways.
    Title: Deficiency in the double-stranded RNA binding protein HYPONASTIC LEAVES1 increases sensitivity to the endoplasmic reticulum stress inducer tunicamycin in Arabidopsis.
  10. fiery1, hyl1 and se interact and require miRNA precursor processing in Arabidopsis
    Title: Efficiency and precision of microRNA biogenesis modes in plants.
Submit: New GeneRIF Correction See all GeneRIFs (37)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_001331846.1
NM_100842.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables double-stranded RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables double-stranded RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables miRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within leaf proximal/distal pattern formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within leaf vascular tissue pattern formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within miRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within miRNA-mediated gene silencing by mRNA destabilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pre-miRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell fate specification IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within response to abscisic acid IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to auxin IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to cytokinin IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within ta-siRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
NOT located_in Cajal body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear dicing body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
dsRNA-binding domain-like superfamily protein
NP_563850.1
  • HYPONASTIC LEAVES 1 (HYL1); CONTAINS InterPro DOMAIN/s: Double-stranded RNA-binding (InterPro:IPR001159), Double-stranded RNA-binding-like (InterPro:IPR014720); BEST Arabidopsis thaliana protein match is: dsRNA-binding protein 2 (TAIR:AT2G28380.1); Has 992 Blast hits to 893 proteins in 320 species: Archae - 14; Bacteria - 506; Metazoa - 117; Fungi - 6; Plants - 270; Viruses - 0; Other Eukaryotes - 79 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    3137649..3140353 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_100842.4 → NP_563850.1  dsRNA-binding domain-like superfamily protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_563850.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    C0Z3F9, O04492
    Conserved Domains (1) summary
    cd00048
    Location:16 → 82
    DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...

  2. NM_001331846.1 → NP_001321280.1  dsRNA-binding domain-like superfamily protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8AQD8, A0A7G2DT78
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O04492.1

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