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ACLA-3 ATP-citrate lyase A-3 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 837466, updated on 18-Sep-2024

Summary

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Official Symbol
ACLA-3
Official Full Name
ATP-citrate lyase A-3
Primary source
TAIR:AT1G09430
Locus tag
AT1G09430
See related
Araport:AT1G09430
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATP-citrate lyase A-3; F14J9.9; F14J9_9
Summary
Encodes subunit A of the heteromeric enzyme ATP citrate lyase (ACL). In animals, ACL is encoded by a single gene; ACL in Arabidopsis is composed of two polypeptides, ACLA (encoded by 3 genes) and ACLB (encoded by 2 genes). The holoenzyme has an A(4)B(4)stoichiometry. Expression of both ACLA and ACLB but not of either of the subunits alone results in ACL activity.
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Genomic context

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See ACLA-3 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
12
Sequence:
Chromosome: 1; NC_003070.9 (3041996..3045541)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene NIM1-interacting 3 Neighboring gene ncRNA Neighboring gene glucose-6-phosphate dehydrogenase 4 Neighboring gene Protein kinase superfamily protein Neighboring gene Protein kinase superfamily protein Neighboring gene Carbohydrate-binding X8 domain superfamily protein Neighboring gene myosin heavy chain, cardiac protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular characterization of a heteromeric ATP-citrate lyase that generates cytosolic acetyl-coenzyme A in Arabidopsis. Fatland BL, et al. Plant Physiol, 2002 Oct. PMID 12376641, Free PMC Article
  2. Protein and metabolite composition of Arabidopsis stress granules. Kosmacz M, et al. New Phytol, 2019 May. PMID 30664249
  3. Targeted interactomics reveals a complex core cell cycle machinery in Arabidopsis thaliana. Van Leene J, et al. Mol Syst Biol, 2010 Aug 10. PMID 20706207, Free PMC Article
  4. A proteomic strategy for global analysis of plant protein complexes. Aryal UK, et al. Plant Cell, 2014 Oct. PMID 25293756, Free PMC Article
  5. Global Analysis of Membrane-associated Protein Oligomerization Using Protein Correlation Profiling. McBride Z, et al. Mol Cell Proteomics, 2017 Nov. PMID 28887381, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_100814.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables ATP citrate synthase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within acetyl-CoA biosynthetic process TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of ATP-dependent citrate lyase complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  
located_in cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol HDA PubMed 
located_in extracellular region HDA PubMed 

General protein information

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Preferred Names
ATP-citrate lyase A-3
NP_172414.1
  • ATP-citrate lyase A-3 (ACLA-3); CONTAINS InterPro DOMAIN/s: ATP-grasp fold, subdomain 2 (InterPro:IPR013816), ATP-grasp fold, succinyl-CoA synthetase-type (InterPro:IPR013650), Succinyl-CoA synthetase-like (InterPro:IPR016102); BEST Arabidopsis thaliana protein match is: ATP-citrate lyase A-1 (TAIR:AT1G10670.4); Has 5303 Blast hits to 5302 proteins in 1635 species: Archae - 133; Bacteria - 3235; Metazoa - 230; Fungi - 139; Plants - 96; Viruses - 0; Other Eukaryotes - 1470 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    3041996..3045541
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_100814.4 → NP_172414.1  ATP-citrate lyase A-3 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_172414.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O80526
    UniProtKB/TrEMBL
    A0A178WAZ4, A0A654EA62, A0A7G2DU60
    Conserved Domains (1) summary
    PLN02235
    Location:1 → 423
    PLN02235; ATP citrate (pro-S)-lyase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O80526.1

Gene LinkOut

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