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CVP2 DNAse I-like superfamily protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 837048, updated on 18-Sep-2024

Summary

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Official Symbol
CVP2
Official Full Name
DNAse I-like superfamily protein
Primary source
TAIR:AT1G05470
Locus tag
AT1G05470
See related
Araport:AT1G05470
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
COTYLEDON VASCULAR PATTERN 2; T25N20.12; T25N20_12
Summary
Encodes an inositol polyphosphate 5' phosphatase (5PTase) that is required for the proper recruitment of cells into developing vascular tissue in leaves and cotyledons. It is most similar to Type I 5PTases that are known to cleave a phosphate from IP3 or IP4. cvp2 mutants have elevated levels of IP3 and are hypersensitive to ABA in seed germination assays.
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Genomic context

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See CVP2 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
13
Sequence:
Chromosome: 1; NC_003070.9 (1607202..1611840, complement)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene C-8 sterol isomerase Neighboring gene Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein Neighboring gene P-loop containing nucleoside triphosphate hydrolases superfamily protein Neighboring gene chromatin remodeling 31 Neighboring gene Calcium-dependent lipid-binding (CaLB domain) family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cotyledon vascular pattern2-mediated inositol (1,4,5) triphosphate signal transduction is essential for closed venation patterns of Arabidopsis foliar organs. Carland FM, et al. Plant Cell, 2004 May. PMID 15100402, Free PMC Article
  2. Primary root protophloem differentiation requires balanced phosphatidylinositol-4,5-biphosphate levels and systemically affects root branching. Rodriguez-Villalon A, et al. Development, 2015 Apr 15. PMID 25813544
  3. CVP2- and CVL1-mediated phosphoinositide signaling as a regulator of the ARF GAP SFC/VAN3 in establishment of foliar vein patterns. Carland F, et al. Plant J, 2009 Sep. PMID 19473324
  4. Genetic regulation of vascular tissue patterning in Arabidopsis. Carland FM, et al. Plant Cell, 1999 Nov. PMID 10559439, Free PMC Article
  5. Phosphoinositide-dependent regulation of VAN3 ARF-GAP localization and activity essential for vascular tissue continuity in plants. Naramoto S, et al. Development, 2009 May. PMID 19363154

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CVP2 and CVL1 regulate vein continuity and cell polarity by generating a specific phosphoinositide ligand for SFC/VAN3.
    Title: CVP2- and CVL1-mediated phosphoinositide signaling as a regulator of the ARF GAP SFC/VAN3 in establishment of foliar vein patterns.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001331550.1
NM_100426.5

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables inositol trisphosphate phosphatase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables inositol-polyphosphate 5-phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
NOT involved_in auxin metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cotyledon vascular tissue pattern formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within inositol trisphosphate metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within leaf vascular tissue pattern formation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within leaf vascular tissue pattern formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phosphatidylinositol dephosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phosphatidylinositol dephosphorylation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within procambium histogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to abscisic acid IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within xylem and phloem pattern formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
DNAse I-like superfamily protein
NP_172038.4
  • COTYLEDON VASCULAR PATTERN 2 (CVP2); FUNCTIONS IN: hydrolase activity, inositol trisphosphate phosphatase activity; INVOLVED IN: in 8 processes; LOCATED IN: cellular_component unknown; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 8 growth stages; CONTAINS InterPro DOMAIN/s: Inositol polyphosphate related phosphatase (InterPro:IPR000300), Endonuclease/exonuclease/phosphatase (InterPro:IPR005135); BEST Arabidopsis thaliana protein match is: CVP2 like 1 (TAIR:AT2G32010.2); Has 2640 Blast hits to 2079 proteins in 233 species: Archae - 0; Bacteria - 28; Metazoa - 855; Fungi - 611; Plants - 735; Viruses - 0; Other Eukaryotes - 411 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    1607202..1611840 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_100426.5 → NP_172038.4  DNAse I-like superfamily protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_172038.4

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9LR47
    UniProtKB/TrEMBL
    A0A178WIE4, A0A5S9SRT5, A0A7G2DSX5
    Conserved Domains (1) summary
    cl00490
    Location:1 → 605
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

  2. NM_001331550.1 → NP_001322092.1  DNAse I-like superfamily protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9LR47
    UniProtKB/TrEMBL
    A0A178WIE4, A0A5S9SRT5, A0A7G2DSX5
    Conserved Domains (1) summary
    cl00490
    Location:1 → 605
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9LR47.2

Gene LinkOut

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