PARP9 poly(ADP-ribose) polymerase family member 9 [Homo sapiens (human)] - Gene

Summary

Official Symbol: PARP9provided by HGNC
Official Full Name: poly(ADP-ribose) polymerase family member 9provided by HGNC
Primary source: HGNC:HGNC:24118
See related: Ensembl:ENSG00000138496 MIM:612065; AllianceGenome:HGNC:24118
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: BAL; BAL1; ARTD9; MGC:7868
Summary: Enables several functions, including ADP-D-ribose binding activity; NAD+-protein ADP-ribosyltransferase activity; and STAT family protein binding activity. Involved in several processes, including positive regulation of tyrosine phosphorylation of STAT protein; regulation of defense response; and regulation of gene expression. Located in several cellular components, including mitochondrion; nucleoplasm; and site of DNA damage. Part of protein-containing complex. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in spleen (RPKM 10.3), appendix (RPKM 10.1) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 3q21.1

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	3	NC_000003.12 (122527924..122564784, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	3	NC_060927.1 (125247222..125284030, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (122246771..122283631, complement)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

P. gingivalis-Induced TLR2 Interactome Analysis Reveals Association with PARP9.
Title: P. gingivalis-Induced TLR2 Interactome Analysis Reveals Association with PARP9.
Poly(ADP-ribose) polymerase 9 mediates early protection against Mycobacterium tuberculosis infection by regulating type I IFN production.
Title: Poly(ADP-ribose) polymerase 9 mediates early protection against Mycobacterium tuberculosis infection by regulating type I IFN production.
The SARS-CoV-2 Nsp3 macrodomain reverses PARP9/DTX3L-dependent ADP-ribosylation induced by interferon signaling.
Title: The SARS-CoV-2 Nsp3 macrodomain reverses PARP9/DTX3L-dependent ADP-ribosylation induced by interferon signaling.
Molecular and clinical characterization of PARP9 in gliomas: A potential immunotherapeutic target.
Title: Molecular and clinical characterization of PARP9 in gliomas: A potential immunotherapeutic target.
Decylubiquinone suppresses breast cancer growth and metastasis by inhibiting angiogenesis via the ROS/p53/ BAI1 signaling pathway.
Title: Decylubiquinone suppresses breast cancer growth and metastasis by inhibiting angiogenesis via the ROS/p53/ BAI1 signaling pathway.
Identification of poly(ADP-ribose) polymerase 9 (PARP9) as a noncanonical sensor for RNA virus in dendritic cells.
Title: Identification of poly(ADP-ribose) polymerase 9 (PARP9) as a noncanonical sensor for RNA virus in dendritic cells.
Androgen signaling uses a writer and a reader of ADP-ribosylation to regulate protein complex assembly.
Title: Androgen signaling uses a writer and a reader of ADP-ribosylation to regulate protein complex assembly.
Engineering Af1521 improves ADP-ribose binding and identification of ADP-ribosylated proteins.
Title: Engineering Af1521 improves ADP-ribose binding and identification of ADP-ribosylated proteins.
This study summarizes specific molecular pathways, including those involving poly(ADP-ribose) polymerase family member 14 (PARP14) and poly(ADP-ribose) polymerase family member 9 (PARP9) at the intersection of interferon gamma (IFN-gamma) and ADP-ribosylation signaling pathways.
Title: A Study into the ADP-Ribosylome of IFN-γ-Stimulated THP-1 Human Macrophage-like Cells Identifies ARTD8/PARP14 and ARTD9/PARP9 ADP-Ribosylation.
PARP9 and PARP14 regulate macrophage activation in macrophage cell lines treated with either IFNgamma or IL-4; PARP14 silencing induces pro-inflammatory genes and STAT1 phosphorylation in M(IFNgamma) cells, whereas it suppresses anti-inflammatory gene expression and STAT6 phosphorylation in M(IL-4) cells
Title: PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A mega-analysis of genome-wide association studies for major depressive disorder. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of poly (ADP-ribose) polymerase family, member 9 (PARP9) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	HIV-1 Tat upregulates the expression of poly (ADP-ribose) polymerase family, member 9 (PARP9) in human primary T cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Clone Names

FLJ26637, FLJ35310, FLJ41418, FLJ43593, DKFZp666B0810, DKFZp686M15238

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ADP-D-ribose binding	IMP Inferred from Mutant Phenotype more info	PubMed
NOT enables NAD+ binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables NAD+-protein ADP-ribosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables NAD+-protein poly-ADP-ribosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
NOT enables NAD+-protein poly-ADP-ribosyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables NAD+-protein poly-ADP-ribosyltransferase activity	TAS Traceable Author Statement more info
enables NAD+-protein-C-terminal glycine ADP-ribosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables STAT family protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables enzyme inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables histone binding	IPI Inferred from Physical Interaction more info	PubMed
enables nucleotidyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ubiquitin-like protein ligase binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-like protein ligase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA damage checkpoint signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in NAD biosynthesis via nicotinamide riboside salvage pathway	TAS Traceable Author Statement more info
involved_in cell migration	TAS Traceable Author Statement more info	PubMed
involved_in defense response to virus	IEA Inferred from Electronic Annotation more info
involved_in double-strand break repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of catalytic activity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of chromatin binding	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of defense response to virus by host	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of protein localization to nucleus	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of type II interferon-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of type II interferon-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of tyrosine phosphorylation of STAT protein	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in post-transcriptional regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in protein poly-ADP-ribosylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of response to type II interferon	IDA Inferred from Direct Assay more info	PubMed
involved_in viral protein processing	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
located_in membrane	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleus	IC Inferred by Curator more info	PubMed
colocalizes_with nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	TAS Traceable Author Statement more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
located_in site of DNA damage	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: protein mono-ADP-ribosyltransferase PARP9

Names: ADP-ribosyltransferase diphtheria toxin-like 9; PARP-9; b aggressive lymphoma protein; poly (ADP-ribose) polymerase 9; poly [ADP-ribose] polymerase 9

NP_001139574.1

EC 2.4.2.30

NP_001139575.1

EC 2.4.2.30

NP_001139576.1

EC 2.4.2.30

NP_001139577.1

EC 2.4.2.30

NP_001139578.1

EC 2.4.2.30

NP_001374800.1

EC 2.4.2.30

NP_001374801.1

EC 2.4.2.30

NP_001374802.1

EC 2.4.2.30

NP_001374803.1

EC 2.4.2.30

NP_001374804.1

EC 2.4.2.30

NP_001374805.1

EC 2.4.2.30

NP_001374806.1

EC 2.4.2.30

NP_001374807.1

EC 2.4.2.30

NP_001374808.1

EC 2.4.2.30

NP_001374809.1

EC 2.4.2.30

NP_001374810.1

EC 2.4.2.30

NP_001374811.1

EC 2.4.2.30

NP_001374812.1

EC 2.4.2.30

NP_001374813.1

EC 2.4.2.30

NP_001374814.1

EC 2.4.2.30

NP_001374815.1

EC 2.4.2.30

NP_001374816.1

EC 2.4.2.30

NP_113646.2

EC 2.4.2.30

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001146102.2 → NP_001139574.1 protein mono-ADP-ribosyltransferase PARP9 isoform a

See identical proteins and their annotated locations for NP_001139574.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (a).

Source sequence(s)

AK313494, BC039580, DC368112

Consensus CDS

CCDS3014.1

UniProtKB/Swiss-Prot

A8KA94, B2R8S9, E9PFM7, Q8IXQ6, Q8TCP3, Q9BZL8, Q9BZL9

UniProtKB/TrEMBL

B7Z5L6

Conserved Domains (3) summary

cd01439
Location:702 → 821

TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...

cd02903
Location:310 → 486

Macro_BAL-like; macrodomain, B-aggressive lymphoma (BAL)-like family

cd02907
Location:117 → 277

Macro_Af1521_BAL-like; macrodomain, Af1521-like family
NM_001146103.2 → NP_001139575.1 protein mono-ADP-ribosyltransferase PARP9 isoform b

See identical proteins and their annotated locations for NP_001139575.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a. Variants 3, 4 and 5 encode the same isoform (b).

Source sequence(s)

AC092908, AF307339, AL713679, BU675792, DB096326

Consensus CDS

CCDS54634.1

UniProtKB/TrEMBL

B7Z5L6

Related

ENSP00000419506.1, ENST00000477522.6

Conserved Domains (3) summary

cd01439
Location:667 → 786

TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...

cd02903
Location:275 → 451

Macro_BAL-like; macrodomain, B-aggressive lymphoma (BAL)-like family

cd02907
Location:82 → 242

Macro_Af1521_BAL-like; macrodomain, Af1521-like family
NM_001146104.2 → NP_001139576.1 protein mono-ADP-ribosyltransferase PARP9 isoform b

See identical proteins and their annotated locations for NP_001139576.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a. Variants 3, 4 and 5 encode the same isoform (b).

Source sequence(s)

BC039580, DC309545

Consensus CDS

CCDS54634.1

UniProtKB/TrEMBL

B7Z5L6

Related

ENSP00000419001.1, ENST00000471785.5

Conserved Domains (3) summary

cd01439
Location:667 → 786

TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...

cd02903
Location:275 → 451

Macro_BAL-like; macrodomain, B-aggressive lymphoma (BAL)-like family

cd02907
Location:82 → 242

Macro_Af1521_BAL-like; macrodomain, Af1521-like family
NM_001146105.2 → NP_001139577.1 protein mono-ADP-ribosyltransferase PARP9 isoform b

See identical proteins and their annotated locations for NP_001139577.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a. Variants 3, 4 and 5 encode the same isoform (b).

Source sequence(s)

BC039580, DC368112

Consensus CDS

CCDS54634.1

UniProtKB/TrEMBL

B7Z5L6

Related

ENSP00000507390.1, ENST00000682323.1

Conserved Domains (3) summary

cd01439
Location:667 → 786

TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...

cd02903
Location:275 → 451

Macro_BAL-like; macrodomain, B-aggressive lymphoma (BAL)-like family

cd02907
Location:82 → 242

Macro_Af1521_BAL-like; macrodomain, Af1521-like family
NM_001146106.3 → NP_001139578.1 protein mono-ADP-ribosyltransferase PARP9 isoform c

Status: VALIDATED

Description

Transcript Variant: This variant (6) differs in the 5' UTR, 3' UTR and 3' coding region, compared to variant 1, which results in a frameshift. The encoded protein (isoform c) has a shorter and distinct C-terminus, compared to isoform a.

Source sequence(s)

AB209742, AC092908, AK092629, BC017463, BP259272

Consensus CDS

CCDS54633.1

UniProtKB/TrEMBL

B7Z5L6

Related

ENSP00000418894.1, ENST00000462315.5

Conserved Domains (3) summary

cd02903
Location:275 → 451

Macro_BAL-like; macrodomain, B-aggressive lymphoma (BAL)-like family

cd02907
Location:82 → 242

Macro_Af1521_BAL-like; macrodomain, Af1521-like family

cl00283
Location:667 → 695

ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
NM_001387871.1 → NP_001374800.1 protein mono-ADP-ribosyltransferase PARP9 isoform a

Status: VALIDATED

Source sequence(s)

AC092908, AC096861

Consensus CDS

CCDS3014.1

UniProtKB/Swiss-Prot

A8KA94, B2R8S9, E9PFM7, Q8IXQ6, Q8TCP3, Q9BZL8, Q9BZL9

UniProtKB/TrEMBL

B7Z5L6

Conserved Domains (3) summary

cd01439
Location:702 → 821

TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...

cd02903
Location:310 → 486

Macro_BAL-like; macrodomain, B-aggressive lymphoma (BAL)-like family

cd02907
Location:117 → 277

Macro_Af1521_BAL-like; macrodomain, Af1521-like family
NM_001387872.1 → NP_001374801.1 protein mono-ADP-ribosyltransferase PARP9 isoform a

Status: VALIDATED

Source sequence(s)

AC092908, AC096861

Consensus CDS

CCDS3014.1

UniProtKB/Swiss-Prot

A8KA94, B2R8S9, E9PFM7, Q8IXQ6, Q8TCP3, Q9BZL8, Q9BZL9

UniProtKB/TrEMBL

B7Z5L6

Conserved Domains (3) summary

cd01439
Location:702 → 821

TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...

cd02903
Location:310 → 486

Macro_BAL-like; macrodomain, B-aggressive lymphoma (BAL)-like family

cd02907
Location:117 → 277

Macro_Af1521_BAL-like; macrodomain, Af1521-like family
NM_001387873.1 → NP_001374802.1 protein mono-ADP-ribosyltransferase PARP9 isoform d

Status: VALIDATED

Source sequence(s)

AC092908, AC096861

UniProtKB/TrEMBL

B7Z5L6

Conserved Domains (3) summary

cd01439
Location:680 → 799

TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...

cd02903
Location:288 → 464

Macro_BAL-like; macrodomain, B-aggressive lymphoma (BAL)-like family

cd02907
Location:95 → 255

Macro_Af1521_BAL-like; macrodomain, Af1521-like family
NM_001387874.1 → NP_001374803.1 protein mono-ADP-ribosyltransferase PARP9 isoform d

Status: VALIDATED

Source sequence(s)

AC092908, AC096861

UniProtKB/TrEMBL

B7Z5L6

Conserved Domains (3) summary

cd01439
Location:680 → 799

TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...

cd02903
Location:288 → 464

Macro_BAL-like; macrodomain, B-aggressive lymphoma (BAL)-like family

cd02907
Location:95 → 255

Macro_Af1521_BAL-like; macrodomain, Af1521-like family
NM_001387875.1 → NP_001374804.1 protein mono-ADP-ribosyltransferase PARP9 isoform b

Status: VALIDATED

Source sequence(s)

AC092908, AC096861

Consensus CDS

CCDS54634.1

UniProtKB/TrEMBL

B7Z5L6

Conserved Domains (3) summary

cd01439
Location:667 → 786

TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...

cd02903
Location:275 → 451

Macro_BAL-like; macrodomain, B-aggressive lymphoma (BAL)-like family

cd02907
Location:82 → 242

Macro_Af1521_BAL-like; macrodomain, Af1521-like family
NM_001387876.1 → NP_001374805.1 protein mono-ADP-ribosyltransferase PARP9 isoform b

Status: VALIDATED

Source sequence(s)

AC092908, AC096861

Consensus CDS

CCDS54634.1

UniProtKB/TrEMBL

B7Z5L6

Conserved Domains (3) summary

cd01439
Location:667 → 786

TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...

cd02903
Location:275 → 451

Macro_BAL-like; macrodomain, B-aggressive lymphoma (BAL)-like family

cd02907
Location:82 → 242

Macro_Af1521_BAL-like; macrodomain, Af1521-like family
NM_001387877.1 → NP_001374806.1 protein mono-ADP-ribosyltransferase PARP9 isoform b

Status: VALIDATED

Source sequence(s)

AC092908, AC096861

Consensus CDS

CCDS54634.1

UniProtKB/TrEMBL

B7Z5L6

Conserved Domains (3) summary

cd01439
Location:667 → 786

TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...

cd02903
Location:275 → 451

Macro_BAL-like; macrodomain, B-aggressive lymphoma (BAL)-like family

cd02907
Location:82 → 242

Macro_Af1521_BAL-like; macrodomain, Af1521-like family
NM_001387878.1 → NP_001374807.1 protein mono-ADP-ribosyltransferase PARP9 isoform e

Status: VALIDATED

Source sequence(s)

AC092908, AC096861

UniProtKB/TrEMBL

B7Z5L6

Conserved Domains (3) summary

cd02903
Location:310 → 486

Macro_BAL-like; macrodomain, B-aggressive lymphoma (BAL)-like family

cd02907
Location:117 → 277

Macro_Af1521_BAL-like; macrodomain, Af1521-like family

cl00283
Location:702 → 729

ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
NM_001387879.1 → NP_001374808.1 protein mono-ADP-ribosyltransferase PARP9 isoform e

Status: VALIDATED

Source sequence(s)

AC092908, AC096861

UniProtKB/TrEMBL

B7Z5L6

Conserved Domains (3) summary

cd02903
Location:310 → 486

Macro_BAL-like; macrodomain, B-aggressive lymphoma (BAL)-like family

cd02907
Location:117 → 277

Macro_Af1521_BAL-like; macrodomain, Af1521-like family

cl00283
Location:702 → 729

ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
NM_001387880.1 → NP_001374809.1 protein mono-ADP-ribosyltransferase PARP9 isoform f

Status: VALIDATED

Source sequence(s)

AC092908

UniProtKB/TrEMBL

B7Z5L6

Conserved Domains (3) summary

cd02903
Location:310 → 486

Macro_BAL-like; macrodomain, B-aggressive lymphoma (BAL)-like family

cd02907
Location:117 → 277

Macro_Af1521_BAL-like; macrodomain, Af1521-like family

cl00283
Location:702 → 730

ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
NM_001387881.1 → NP_001374810.1 protein mono-ADP-ribosyltransferase PARP9 isoform g

Status: VALIDATED

Source sequence(s)

AC092908, AC096861

UniProtKB/TrEMBL

B7Z5L6

Conserved Domains (3) summary

cd02903
Location:275 → 451

Macro_BAL-like; macrodomain, B-aggressive lymphoma (BAL)-like family

cd02907
Location:82 → 242

Macro_Af1521_BAL-like; macrodomain, Af1521-like family

cl00283
Location:667 → 694

ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
NM_001387882.1 → NP_001374811.1 protein mono-ADP-ribosyltransferase PARP9 isoform g

Status: VALIDATED

Source sequence(s)

AC092908, AC096861

UniProtKB/TrEMBL

B7Z5L6

Conserved Domains (3) summary

cd02903
Location:275 → 451

Macro_BAL-like; macrodomain, B-aggressive lymphoma (BAL)-like family

cd02907
Location:82 → 242

Macro_Af1521_BAL-like; macrodomain, Af1521-like family

cl00283
Location:667 → 694

ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
NM_001387883.1 → NP_001374812.1 protein mono-ADP-ribosyltransferase PARP9 isoform g

Status: VALIDATED

Source sequence(s)

AC092908, AC096861

UniProtKB/TrEMBL

B7Z5L6

Conserved Domains (3) summary

cd02903
Location:275 → 451

Macro_BAL-like; macrodomain, B-aggressive lymphoma (BAL)-like family

cd02907
Location:82 → 242

Macro_Af1521_BAL-like; macrodomain, Af1521-like family

cl00283
Location:667 → 694

ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
NM_001387884.1 → NP_001374813.1 protein mono-ADP-ribosyltransferase PARP9 isoform g

Status: VALIDATED

Source sequence(s)

AC092908, AC096861

UniProtKB/TrEMBL

B7Z5L6

Conserved Domains (3) summary

cd02903
Location:275 → 451

Macro_BAL-like; macrodomain, B-aggressive lymphoma (BAL)-like family

cd02907
Location:82 → 242

Macro_Af1521_BAL-like; macrodomain, Af1521-like family

cl00283
Location:667 → 694

ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
NM_001387885.1 → NP_001374814.1 protein mono-ADP-ribosyltransferase PARP9 isoform c

Status: VALIDATED

Source sequence(s)

AC092908

Consensus CDS

CCDS54633.1

UniProtKB/TrEMBL

B7Z5L6

Conserved Domains (3) summary

cd02903
Location:275 → 451

Macro_BAL-like; macrodomain, B-aggressive lymphoma (BAL)-like family

cd02907
Location:82 → 242

Macro_Af1521_BAL-like; macrodomain, Af1521-like family

cl00283
Location:667 → 695

ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
NM_001387886.1 → NP_001374815.1 protein mono-ADP-ribosyltransferase PARP9 isoform c

Status: VALIDATED

Source sequence(s)

AC092908

Consensus CDS

CCDS54633.1

UniProtKB/TrEMBL

B7Z5L6

Conserved Domains (3) summary

cd02903
Location:275 → 451

Macro_BAL-like; macrodomain, B-aggressive lymphoma (BAL)-like family

cd02907
Location:82 → 242

Macro_Af1521_BAL-like; macrodomain, Af1521-like family

cl00283
Location:667 → 695

ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
NM_001387887.1 → NP_001374816.1 protein mono-ADP-ribosyltransferase PARP9 isoform c

Status: VALIDATED

Source sequence(s)

AC092908

Consensus CDS

CCDS54633.1

UniProtKB/TrEMBL

B7Z5L6

Conserved Domains (3) summary

cd02903
Location:275 → 451

Macro_BAL-like; macrodomain, B-aggressive lymphoma (BAL)-like family

cd02907
Location:82 → 242

Macro_Af1521_BAL-like; macrodomain, Af1521-like family

cl00283
Location:667 → 695

ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
NM_031458.3 → NP_113646.2 protein mono-ADP-ribosyltransferase PARP9 isoform a

See identical proteins and their annotated locations for NP_113646.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (a). Both variants 1 and 2 encode the same isoform (a).

Source sequence(s)

AC092908, AF307338, AL713679, BU675792, DB096326

Consensus CDS

CCDS3014.1

UniProtKB/Swiss-Prot

A8KA94, B2R8S9, E9PFM7, Q8IXQ6, Q8TCP3, Q9BZL8, Q9BZL9

UniProtKB/TrEMBL

B7Z5L6

Related

ENSP00000353512.2, ENST00000360356.6

Conserved Domains (3) summary

cd01439
Location:702 → 821

TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...

cd02903
Location:310 → 486

Macro_BAL-like; macrodomain, B-aggressive lymphoma (BAL)-like family

cd02907
Location:117 → 277

Macro_Af1521_BAL-like; macrodomain, Af1521-like family

RNA

NR_170857.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC092908, AC096861
NR_170858.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC092908, AC096861
NR_170859.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC092908, AC096861
NR_170860.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC092908, AC096861
NR_170861.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC092908, AC096861
NR_170862.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC092908, AC096861
NR_170863.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC092908
NR_170864.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC092908, AC096861
NR_170865.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC092908, AC096861