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PLC4 phosphatidylinositol-speciwc phospholipase C4 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 835984, updated on 18-Sep-2024

Summary

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Official Symbol
PLC4
Official Full Name
phosphatidylinositol-speciwc phospholipase C4
Primary source
TAIR:AT5G58700
Locus tag
AT5G58700
See related
Araport:AT5G58700
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATPLC4; MZN1.19; MZN1_19; phosphatidylinositol-speciwc phospholipase C4
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Genomic context

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See PLC4 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
11
Sequence:
Chromosome: 5; NC_003076.8 (23712827..23716391, complement)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene ARM repeat superfamily protein Neighboring gene phosphatidylinositol-speciwc phospholipase C5 Neighboring gene rotamase CYP 7 Neighboring gene smr (Small MutS Related) domain-containing protein Neighboring gene pfkB-like carbohydrate kinase family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Stress- and phospholipid signalling responses in Arabidopsis PLC4-KO and -overexpression lines under salt- and osmotic stress. van Hooren M, et al. Phytochemistry, 2023 Dec. PMID 37734512
  2. Arabidopsis phosphoinositide-specific phospholipase C 4 negatively regulates seedling salt tolerance. Xia K, et al. Plant Cell Environ, 2017 Aug. PMID 28102910
  3. Petunia phospholipase c1 is involved in pollen tube growth. Dowd PE, et al. Plant Cell, 2006 Jun. PMID 16648366, Free PMC Article
  4. ABC transporter PEN3/PDR8/ABCG36 interacts with calmodulin that, like PEN3, is required for Arabidopsis nonhost resistance. Campe R, et al. New Phytol, 2016 Jan. PMID 26315018
  5. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Stress- and phospholipid signalling responses in Arabidopsis PLC4-KO and -overexpression lines under salt- and osmotic stress.
    Title: Stress- and phospholipid signalling responses in Arabidopsis PLC4-KO and -overexpression lines under salt- and osmotic stress.
  2. AtPLC4 negatively regulates the salt tolerance of Arabidopsis seedlings, and Ca(2+) may be involved in regulating this process.
    Title: Arabidopsis phosphoinositide-specific phospholipase C 4 negatively regulates seedling salt tolerance.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_001037020.2
NM_001345319.1
NM_125257.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables phosphatidylinositol phospholipase C activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrion ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
phosphatidylinositol-speciwc phospholipase C4
NP_001032097.1
  • phosphatidylinositol-speciwc phospholipase C4 (PLC4); FUNCTIONS IN: phosphoinositide phospholipase C activity, phospholipase C activity, phosphoric diester hydrolase activity; INVOLVED IN: signal transduction, intracellular signaling pathway, lipid metabolic process; LOCATED IN: plasma membrane; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Phospholipase C, phosphatidylinositol-specific, X domain (InterPro:IPR000909), C2 calcium/lipid-binding domain, CaLB (InterPro:IPR008973), Phospholipase C, phosphoinositol-specific (InterPro:IPR001192), Phospholipase C, phosphatidylinositol-specific, Y domain (InterPro:IPR001711), PLC-like phosphodiesterase, TIM beta/alpha-barrel domain (InterPro:IPR017946), C2 membrane targeting protein (InterPro:IPR018029), C2 calcium-dependent membrane targeting (InterPro:IPR000008); BEST Arabidopsis thaliana protein match is: Phosphoinositide-specific phospholipase C family protein (TAIR:AT2G40116.1); Has 2441 Blast hits to 1951 proteins in 262 species: Archae - 0; Bacteria - 0; Metazoa - 1601; Fungi - 365; Plants - 252; Viruses - 0; Other Eukaryotes - 223 (source: NCBI BLink).
NP_001318832.1
  • phosphatidylinositol-speciwc phospholipase C4 (PLC4); FUNCTIONS IN: phospholipase C activity, phosphoinositide phospholipase C activity, phosphoric diester hydrolase activity; INVOLVED IN: signal transduction, intracellular signaling pathway, lipid metabolic process; LOCATED IN: plasma membrane; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Phospholipase C, phosphoinositol-specific, EF-hand-like (InterPro:IPR015359), Phospholipase C, phosphatidylinositol-specific, X domain (InterPro:IPR000909), C2 calcium/lipid-binding domain, CaLB (InterPro:IPR008973), Phospholipase C, phosphoinositol-specific (InterPro:IPR001192), Phospholipase C, phosphatidylinositol-specific, Y domain (InterPro:IPR001711), PLC-like phosphodiesterase, TIM beta/alpha-barrel domain (InterPro:IPR017946), C2 membrane targeting protein (InterPro:IPR018029), C2 calcium-dependent membrane targeting (InterPro:IPR000008); BEST Arabidopsis thaliana protein match is: Phosphoinositide-specific phospholipase C family protein (TAIR:AT2G40116.1); Has 2449 Blast hits to 1960 proteins in 260 species: Archae - 0; Bacteria - 0; Metazoa - 1604; Fungi - 359; Plants - 253; Viruses - 0; Other Eukaryotes - 233 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    23712827..23716391 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001345319.1 → NP_001318832.1  phosphatidylinositol-speciwc phospholipase C4 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q2V2X4, Q940R9, Q944C1, Q9LUY9
    UniProtKB/TrEMBL
    A0A178UP87, A0A5S9YF77
    Conserved Domains (1) summary
    PLN02230
    Location:1 → 597
    PLN02230; phosphoinositide phospholipase C 4

  2. NM_125257.3 → NP_200678.2  phosphatidylinositol-speciwc phospholipase C4 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_200678.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q2V2X4, Q940R9, Q944C1, Q9LUY9
    UniProtKB/TrEMBL
    A0A178UP87, A0A5S9YF77
    Conserved Domains (1) summary
    PLN02230
    Location:1 → 597
    PLN02230; phosphoinositide phospholipase C 4

  3. NM_001037020.2 → NP_001032097.1  phosphatidylinositol-speciwc phospholipase C4 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001032097.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A5S9YF77, B9DGG5
    Conserved Domains (2) summary
    cd00275
    Location:359 → 488
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08599
    Location:5 → 328
    PI-PLCc_plant; Catalytic domain of plant phosphatidylinositide-specific phospholipases C
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q944C1.2

Gene LinkOut

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