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ACD5 Diacylglycerol kinase family protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 835203, updated on 18-Sep-2024

Summary

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Official Symbol
ACD5
Official Full Name
Diacylglycerol kinase family protein
Primary source
TAIR:AT5G51290
Locus tag
AT5G51290
See related
Araport:AT5G51290
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ACCELERATED CELL DEATH 5; MWD22.24; MWD22_24
Summary
Encodes a ceramide kinase that plays a role in modulating cell death.
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Genomic context

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See ACD5 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
13
Sequence:
Chromosome: 5; NC_003076.8 (20843923..20848376, complement)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene HAD superfamily, subfamily IIIB acid phosphatase Neighboring gene U-box domain-containing protein kinase family protein Neighboring gene DEAD-box protein abstrakt Neighboring gene splicing factor-like protein Neighboring gene 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Jasmonates modulate sphingolipid metabolism and accelerate cell death in the ceramide kinase mutant acd5. Huang LQ, et al. Plant Physiol, 2021 Nov 3. PMID 34618068, Free PMC Article
  2. Salt Enhances Disease Resistance and Suppresses Cell Death in Ceramide Kinase Mutants. Yang YB, et al. Plant Physiol, 2019 Sep. PMID 31243063, Free PMC Article
  3. Evidence for ACD5 ceramide kinase activity involvement in Arabidopsis response to cold stress. Dutilleul C, et al. Plant Cell Environ, 2015 Dec. PMID 26013074
  4. Loss of ceramide kinase in Arabidopsis impairs defenses and promotes ceramide accumulation and mitochondrial H2O2 bursts. Bi FC, et al. Plant Cell, 2014 Aug. PMID 25149397, Free PMC Article
  5. Ceramides modulate programmed cell death in plants. Liang H, et al. Genes Dev, 2003 Nov 1. PMID 14563678, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Jasmonates modulate sphingolipid metabolism and accelerate cell death in the ceramide kinase mutant acd5.
    Title: Jasmonates modulate sphingolipid metabolism and accelerate cell death in the ceramide kinase mutant acd5.
  2. Salt Enhances Disease Resistance and Suppresses Cell Death in Ceramide Kinase Mutants.
    Title: Salt Enhances Disease Resistance and Suppresses Cell Death in Ceramide Kinase Mutants.
  3. The data involve for the first time ceramide phosphates (Cer-Ps) and ACD5 in low temperature response and further underline the complexity of sphingolipid signalling operating during cold stress.
    Title: Evidence for ACD5 ceramide kinase activity involvement in Arabidopsis response to cold stress.
  4. ACD5 is associated with cermide accumulation and Arabidopsis antifungal response. [ACD5]
    Title: Loss of ceramide kinase in Arabidopsis impairs defenses and promotes ceramide accumulation and mitochondrial H2O2 bursts.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

NM_001344933.1
NM_124508.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables calcium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ceramide kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ceramide kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within ceramide metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within programmed cell death IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of programmed cell death IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
Diacylglycerol kinase family protein
NP_568756.2
  • Diacylglycerol kinase family protein; FUNCTIONS IN: diacylglycerol kinase activity; INVOLVED IN: activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway; LOCATED IN: cellular_component unknown; EXPRESSED IN: 12 plant structures; EXPRESSED DURING: 6 growth stages; CONTAINS InterPro DOMAIN/s: Diacylglycerol kinase, catalytic domain (InterPro:IPR001206); BEST Arabidopsis thaliana protein match is: long-chain base (LCB) kinase 1 (TAIR:AT5G23450.3); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    20843923..20848376 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_124508.4 → NP_568756.2  Diacylglycerol kinase family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_568756.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q6USK2, Q9LU45
    UniProtKB/TrEMBL
    A0A5S9YFA5, A0A654G9X1
    Conserved Domains (2) summary
    PLN02204
    Location:1 → 608
    PLN02204; diacylglycerol kinase
    COG1597
    Location:163 → 603
    LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]

  2. NM_001344933.1 → NP_001331641.1  Diacylglycerol kinase family protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8BEG7
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6USK2.1

Gene LinkOut

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