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HSD1 hydroxysteroid dehydrogenase 1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 835129, updated on 18-Sep-2024

Summary

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Official Symbol
HSD1
Official Full Name
hydroxysteroid dehydrogenase 1
Primary source
TAIR:AT5G50600
Locus tag
AT5G50600
See related
Araport:AT5G50600
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATHSD1; hydroxysteroid dehydrogenase 1; HYDROXYSTEROID DEHYDROGENASE 1; MFB16.22
Summary
Encodes a hydroxysteroid dehydrogenase shown to act as a NADP+-dependent 11β-,17β-hydroxysteroid dehydrogenase/17β-ketosteroid reductase called HSD1. Two copies of HSD1 (At5g50600 and At5g50700) exist in the Arabidopsis genome as a result of an exact 33-kb duplication on chromosome 5 encompassing seven genes. There are five homologs of HSD1 in Arabidopsis (HSD2-At3g47350, HSD3-At3g47360, HSD4-At5g50590, HSD4-At5g50690 and HSD6-At5g50770; HSD4 has two copies due to the same gene duplication event occurred to HSD1) (Plant Cell Physiology 50:1463). At5g50690 is also named as HSD7 (Plant Physiology 145:87). HSD1 is identified from the proteome of oil bodies from mature seeds. Transcription of HSD1 is specifically and highly induced in oil-accumulating tissues of mature seeds; transcript disappears during germination. To date, the endogenous substrates of this enzyme are not known.
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Genomic context

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See HSD1 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
6
Sequence:
Chromosome: 5; NC_003076.8 (20589702..20591937, complement)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene SUMO-activating enzyme 1B Neighboring gene hydroxysteroid dehydrogenase 4 Neighboring gene uncharacterized protein Neighboring gene miscRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Regulation of HSD1 in seeds of Arabidopsis thaliana. Baud S, et al. Plant Cell Physiol, 2009 Aug. PMID 19542545
  2. A putative hydroxysteroid dehydrogenase involved in regulating plant growth and development. Li F, et al. Plant Physiol, 2007 Sep. PMID 17616511, Free PMC Article
  3. At5g50600 encodes a member of the short-chain dehydrogenase reductase superfamily with 11beta- and 17beta-hydroxysteroid dehydrogenase activities associated with Arabidopsis thaliana seed oil bodies. d'Andréa S, et al. Biochimie, 2007 Feb. PMID 17074428
  4. Identification and characterization of nuclear pore complex components in Arabidopsis thaliana. Tamura K, et al. Plant Cell, 2010 Dec. PMID 21189294, Free PMC Article
  5. Evidence for network evolution in an Arabidopsis interactome map. Arabidopsis Interactome Mapping Consortium. Science, 2011 Jul 29. PMID 21798944, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_124448.5

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables 11-beta-hydroxysteroid dehydrogenase (NADP+) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 11-beta-hydroxysteroid dehydrogenase (NADP+) activity IEA
Inferred from Electronic Annotation
more info
  
enables 17-beta-hydroxysteroid dehydrogenase (NADP+) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 17-beta-ketosteroid reductase (NADPH) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cortisol dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within response to abscisic acid IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to brassinosteroid IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within steroid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
hydroxysteroid dehydrogenase 1
NP_568742.1
  • hydroxysteroid dehydrogenase 1 (HSD1); FUNCTIONS IN: oxidoreductase activity, binding, catalytic activity; INVOLVED IN: response to abscisic acid stimulus, response to brassinosteroid stimulus; LOCATED IN: endomembrane system; EXPRESSED IN: 9 plant structures; CONTAINS InterPro DOMAIN/s: Short-chain dehydrogenase/reductase, conserved site (InterPro:IPR020904), NAD(P)-binding domain (InterPro:IPR016040), Glucose/ribitol dehydrogenase (InterPro:IPR002347), Short-chain dehydrogenase/reductase SDR (InterPro:IPR002198); BEST Arabidopsis thaliana protein match is: hydroxysteroid dehydrogenase 1 (TAIR:AT5G50700.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    20589702..20591937 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_124448.5 → NP_568742.1  hydroxysteroid dehydrogenase 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_568742.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P0DKC5, P0DKC6, Q9LUF1
    UniProtKB/TrEMBL
    A0A178US17, A0A5S9YCY5
    Conserved Domains (1) summary
    cl21454
    Location:47 → 304
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0DKC5.1
P0DKC6.1

Gene LinkOut

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Research Materials