Dynlt1 dynein light chain Tctex-type 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dynlt1provided by RGD
Official Full Name: dynein light chain Tctex-type 1provided by RGD
Primary source: RGD:620261
See related: EnsemblRapid:ENSRNOG00000018207 AllianceGenome:RGD:620261
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: AGS2; Tctex1
Summary: Enables protein C-terminus binding activity. Involved in several processes, including negative regulation of mitochondrial membrane permeability; neuron projection development; and positive regulation of Rac protein signal transduction. Located in axonal growth cone; lamellipodium; and neuronal cell body. Orthologous to human DYNLT1 (dynein light chain Tctex-type 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Testes (RPKM 415.8), Thymus (RPKM 168.6) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1q11

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (49292093..49299051, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (46887017..46893956, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (47206892..47213785, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that DYNLT1 phosphorylation at serine S82 is involved in microtubule and mitochondria regulation, and their interaction and cooperation contribute to the cellular hypoxic tolerance.
Title: Phosphorylation of DYNLT1 at serine 82 regulates microtubule stability and mitochondrial permeabilization in hypoxia.
there are two possible mechanisms triggered by MAP4: stabilization of MT networks; DYNLT1 modulation, which is connected with VDAC1, and inhibition of hypoxia-induced mitochondrial permeabilization
Title: MAP4 mechanism that stabilizes mitochondrial permeability transition in hypoxia: microtubule enhancement and DYNLT1 interaction with VDAC1.
The selective high level of Tctex-1 at the growth cone drives fast neurite extension by modulating actin dynamics
Title: The dynein light chain Tctex-1 has a dynein-independent role in actin remodeling during neurite outgrowth.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G-protein beta-subunit binding	ISO Inferred from Sequence Orthology more info
enables GTP-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables dynein intermediate chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane transporter binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in axon development	IDA Inferred from Direct Assay more info	PubMed
involved_in cardiac muscle cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in dendrite development	IDA Inferred from Direct Assay more info	PubMed
involved_in establishment of mitotic spindle orientation	ISO Inferred from Sequence Orthology more info
involved_in establishment of mitotic spindle orientation	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular protein transport	TAS Traceable Author Statement more info	PubMed
involved_in intracellular transport of viral protein in host cell	IEA Inferred from Electronic Annotation more info
involved_in intracellular transport of viral protein in host cell	ISO Inferred from Sequence Orthology more info
involved_in microtubule-based movement	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mitochondrial membrane permeability	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neurogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neurogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuron projection morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of Rac protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in regulation of G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cytoskeleton organization	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in axonal growth cone	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of cytoplasmic dynein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of cytoplasmic dynein complex	IEA Inferred from Electronic Annotation more info
part_of cytoplasmic dynein complex	ISO Inferred from Sequence Orthology more info
part_of cytoplasmic dynein complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasmic microtubule	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic microtubule	ISO Inferred from Sequence Orthology more info
part_of dynein complex	ISO Inferred from Sequence Orthology more info
located_in growth cone	ISO Inferred from Sequence Orthology more info
located_in host cell	IEA Inferred from Electronic Annotation more info
located_in lamellipodium	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in photoreceptor inner segment	ISO Inferred from Sequence Orthology more info
located_in secretory vesicle	IEA Inferred from Electronic Annotation more info
located_in secretory vesicle	ISO Inferred from Sequence Orthology more info
located_in spindle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: dynein light chain Tctex-type 1

Names: T-complex testis-specific protein 1 homolog; activator of G-protein signaling 2; t-complex testis expressed 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031318.1 → NP_112608.1 dynein light chain Tctex-type 1

See identical proteins and their annotated locations for NP_112608.1

Status: PROVISIONAL

Source sequence(s)

AJ131437

UniProtKB/Swiss-Prot

Q9Z336

UniProtKB/TrEMBL

A0A8L2QD70, B2RYR9

Related

ENSRNOP00000024656.5, ENSRNOT00000024656.5

Conserved Domains (1) summary

cd21462
Location:12 → 113

DLC-like_DYNLT1; dynein light chain (DLC)-like domain found in dynein light chain Tctex-type 1 (DYNLT1) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

49292093..49299051 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006227901.5 → XP_006227963.1 dynein light chain Tctex-type 1 isoform X1

Conserved Domains (1) summary

pfam03645
Location:16 → 91

Tctex-1; Tctex-1 family