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LACS7 long-chain acyl-CoA synthetase 7 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 832820, updated on 18-Sep-2024

Summary

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Official Symbol
LACS7
Official Full Name
long-chain acyl-CoA synthetase 7
Primary source
TAIR:AT5G27600
Locus tag
AT5G27600
See related
Araport:AT5G27600
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATLACS7; F15A18.60; F15A18_60; long-chain acyl-CoA synthetase 7
Summary
Encode peroxisomal long-chain acyl-CoA synthetase. Activates fatty acids for further metabolism. Interacts with PEX5.
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Genomic context

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See LACS7 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
23
Sequence:
Chromosome: 5; NC_003076.8 (9742492..9747024)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene AGAMOUS-like 89 Neighboring gene pseudo Neighboring gene pseudo Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Two long-chain acyl-CoA synthetases from Arabidopsis thaliana involved in peroxisomal fatty acid beta-oxidation. Fulda M, et al. Plant J, 2002 Oct. PMID 12366803
  2. Intrinsic acyl-CoA thioesterase activity of a peroxisomal ATP binding cassette transporter is required for transport and metabolism of fatty acids. De Marcos Lousa C, et al. Proc Natl Acad Sci U S A, 2013 Jan 22. PMID 23288899, Free PMC Article
  3. AtLACS7 interacts with the TPR domains of the PTS1 receptor PEX5. Bonsegna S, et al. Arch Biochem Biophys, 2005 Nov 15. PMID 16256065
  4. Arabidopsis contains nine long-chain acyl-coenzyme a synthetase genes that participate in fatty acid and glycerolipid metabolism. Shockey JM, et al. Plant Physiol, 2002 Aug. PMID 12177484, Free PMC Article
  5. Proteome analysis of Arabidopsis leaf peroxisomes reveals novel targeting peptides, metabolic pathways, and defense mechanisms. Reumann S, et al. Plant Cell, 2007 Oct. PMID 17951448, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_122642.5

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables long-chain fatty acid-CoA ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables long-chain fatty acid-CoA ligase activity TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in fatty acid metabolic process TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within long-chain fatty acid metabolic process TAS
Traceable Author Statement
more info
  
acts_upstream_of_or_within response to ozone IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to salt stress IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus ISM
Inferred from Sequence Model
more info
  
located_in peroxisome HDA PubMed 
located_in peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in peroxisome TAS
Traceable Author Statement
more info
 PubMed 
located_in plastid HDA PubMed 

General protein information

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Preferred Names
long-chain acyl-CoA synthetase 7
NP_198112.2
  • long-chain acyl-CoA synthetase 7 (LACS7); FUNCTIONS IN: protein binding, long-chain fatty acid-CoA ligase activity; INVOLVED IN: response to salt stress, long-chain fatty acid metabolic process, response to ozone; LOCATED IN: peroxisome; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: AMP-binding, conserved site (InterPro:IPR020845), AMP-dependent synthetase/ligase (InterPro:IPR000873); BEST Arabidopsis thaliana protein match is: long-chain acyl-CoA synthetase 6 (TAIR:AT3G05970.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    9742492..9747024
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_122642.5 → NP_198112.2  long-chain acyl-CoA synthetase 7 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_198112.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8GWV4, Q8LKS5
    UniProtKB/TrEMBL
    A0A5S9Y819, A0A654G5E6
    Conserved Domains (2) summary
    PLN02736
    Location:41 → 691
    PLN02736; long-chain acyl-CoA synthetase
    cd05927
    Location:114 → 687
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8LKS5.2

Gene LinkOut

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