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PEX4 peroxin4 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 832645, updated on 18-Sep-2024

Summary

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Official Symbol
PEX4
Official Full Name
peroxin4
Primary source
TAIR:AT5G25760
Locus tag
AT5G25760
See related
Araport:AT5G25760
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
F18A17.10; F18A17_10; peroxin4; UBC21; ubiquitin-conjugating enzyme 21
Summary
mutant displays sucrose-dependent seedling development and reduced lateral root production. PEX4 interacts with PEX22 in a yeast two-hybrid. Necessary for peroxisome biogenesis. The PEX4 and PEX22 pair may be important during the remodeling of peroxisome matrix contents as glyoxysomes transition to leaf peroxisomes.
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Genomic context

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See PEX4 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
5
Sequence:
Chromosome: 5; NC_003076.8 (8967655..8969369)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene RNA polymerase I-associated factor PAF67 Neighboring gene alpha/beta-Hydrolases superfamily protein Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ubiquitin-conjugating activity by PEX4 is required for efficient protein transport to peroxisomes in Arabidopsis thaliana. Mano S, et al. J Biol Chem, 2022 Jun. PMID 35595097, Free PMC Article
  2. Reconstitution of the plant ubiquitination cascade in bacteria using a synthetic biology approach. Han Y, et al. Plant J, 2017 Aug. PMID 28509348
  3. Elevated growth temperature decreases levels of the PEX5 peroxisome-targeting signal receptor and ameliorates defects of Arabidopsis mutants with an impaired PEX4 ubiquitin-conjugating enzyme. Kao YT, et al. BMC Plant Biol, 2015 Sep 16. PMID 26377801, Free PMC Article
  4. Identification and functional characterization of Arabidopsis PEROXIN4 and the interacting protein PEROXIN22. Zolman BK, et al. Plant Cell, 2005 Dec. PMID 16272432, Free PMC Article
  5. A dual role for the S-locus receptor kinase in self-incompatibility and pistil development revealed by an Arabidopsis rdr6 mutation. Tantikanjana T, et al. Plant Cell, 2009 Sep. PMID 19767457, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ubiquitin-conjugating activity by PEX4 is required for efficient protein transport to peroxisomes in Arabidopsis thaliana.
    Title: Ubiquitin-conjugating activity by PEX4 is required for efficient protein transport to peroxisomes in Arabidopsis thaliana.
  2. Growth at elevated temperature did not reduce the fraction of membrane-associated PEX5 in pex4-1 mutants, suggesting that elevated temperature did not restore PEX4 enzymatic function in the mutant.
    Title: Elevated growth temperature decreases levels of the PEX5 peroxisome-targeting signal receptor and ameliorates defects of Arabidopsis mutants with an impaired PEX4 ubiquitin-conjugating enzyme.
  3. PEX4 is necessary for Arabidopsis peroxisomal function. pex4 mutants are sucrose dependent during germination and display reduced responses to the auxin precursor indole-3-butyric acid, presumably due to peroxisomal beta-oxidation defects.
    Title: Identification and functional characterization of Arabidopsis PEROXIN4 and the interacting protein PEROXIN22.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001036862.2
NM_122477.2

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin conjugating enzyme activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within fatty acid beta-oxidation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within peroxisome organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein import into peroxisome matrix IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrion ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
peroxin4
NP_001031939.1
  • peroxin4 (PEX4); CONTAINS InterPro DOMAIN/s: Ubiquitin-conjugating enzyme/RWD-like (InterPro:IPR016135), Ubiquitin-conjugating enzyme, E2 (InterPro:IPR000608); BEST Arabidopsis thaliana protein match is: ubiquitin-conjugating enzyme 29 (TAIR:AT2G16740.1); Has 10357 Blast hits to 10353 proteins in 397 species: Archae - 0; Bacteria - 2; Metazoa - 4640; Fungi - 2157; Plants - 1900; Viruses - 24; Other Eukaryotes - 1634 (source: NCBI BLink).
NP_568476.1
  • peroxin4 (PEX4); CONTAINS InterPro DOMAIN/s: Ubiquitin-conjugating enzyme/RWD-like (InterPro:IPR016135), Ubiquitin-conjugating enzyme, E2 (InterPro:IPR000608); BEST Arabidopsis thaliana protein match is: ubiquitin-conjugating enzyme 29 (TAIR:AT2G16740.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    8967655..8969369
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_122477.2 → NP_568476.1  peroxin4 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_568476.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8LGF7
    UniProtKB/TrEMBL
    A0A5S9Y8C9, A0A654G461
    Conserved Domains (1) summary
    pfam00179
    Location:7 → 148
    UQ_con; Ubiquitin-conjugating enzyme

  2. NM_001036862.2 → NP_001031939.1  peroxin4 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001031939.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8LGF7
    UniProtKB/TrEMBL
    A0A5S9Y8C9, A0A654G461
    Conserved Domains (1) summary
    pfam00179
    Location:7 → 148
    UQ_con; Ubiquitin-conjugating enzyme
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8LGF7.1

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