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LCBK1 long-chain base (LCB) kinase 1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 832411, updated on 18-Sep-2024

Summary

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Official Symbol
LCBK1
Official Full Name
long-chain base (LCB) kinase 1
Primary source
TAIR:AT5G23450
Locus tag
AT5G23450
See related
Araport:AT5G23450
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATLCBK1; K19M13.8; K19M13_8; long-chain base (LCB) kinase 1; SPHINGOSINE KINASE
Summary
Encodes a sphingosine kinase that specifically phosphorylates D-erythro-dihydrosphingosine (DHS), but not N-acetyl-DHS or D-threo-DHS. It also also phosphorylates D-erythro-sphingosine, trans-4, trans-8-sphingadienine and phytosphingosine.
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Genomic context

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See LCBK1 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
12
Sequence:
Chromosome: 5; NC_003076.8 (7904293..7909623, complement)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Transducin/WD40 repeat-like superfamily protein Neighboring gene ferredoxin/thioredoxin reductase subunit A (variable subunit) 1 Neighboring gene uncharacterized protein Neighboring gene Haloacid dehalogenase-like hydrolase (HAD) superfamily protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. MEDEA-interacting protein LONG-CHAIN BASE KINASE 1 promotes pattern-triggered immunity in Arabidopsis thaliana. Gupta P, et al. Plant Mol Biol, 2020 May. PMID 32100164
  2. Phosphorylation of sphingoid long-chain bases in Arabidopsis: functional characterization and expression of the first sphingoid long-chain base Kinase gene in plants. Imai H, et al. Plant Cell Physiol, 2005 Feb. PMID 15695468
  3. The calmodulin-binding protein kinase 3 is part of heat-shock signal transduction in Arabidopsis thaliana. Liu HT, et al. Plant J, 2008 Sep. PMID 18466301
  4. Border control--a membrane-linked interactome of Arabidopsis. Jones AM, et al. Science, 2014 May 16. PMID 24833385
  5. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LCBK1 is an interactor of MEA that positively regulates pattern-triggered immunity induced stomatal closure in Arabidopsis
    Title: MEDEA-interacting protein LONG-CHAIN BASE KINASE 1 promotes pattern-triggered immunity in Arabidopsis thaliana.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001036852.4
NM_001343804.1
NM_122252.4
NM_180734.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables D-erythro-sphingosine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within sphingolipid biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in sphingolipid biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
long-chain base (LCB) kinase 1
NP_001031929.4
  • long-chain base (LCB) kinase 1 (LCBK1); FUNCTIONS IN: diacylglycerol kinase activity, D-erythro-sphingosine kinase activity; INVOLVED IN: activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway, sphingolipid biosynthetic process; LOCATED IN: plasma membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Diacylglycerol kinase, catalytic domain (InterPro:IPR001206); BEST Arabidopsis thaliana protein match is: sphingosine kinase 1 (TAIR:AT4G21540.1); Has 1850 Blast hits to 1642 proteins in 445 species: Archae - 2; Bacteria - 669; Metazoa - 552; Fungi - 144; Plants - 247; Viruses - 0; Other Eukaryotes - 236 (source: NCBI BLink).
NP_568432.1
  • long-chain base (LCB) kinase 1 (LCBK1); FUNCTIONS IN: diacylglycerol kinase activity, D-erythro-sphingosine kinase activity; INVOLVED IN: activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway, sphingolipid biosynthetic process; LOCATED IN: plasma membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Diacylglycerol kinase, catalytic domain (InterPro:IPR001206); BEST Arabidopsis thaliana protein match is: sphingosine kinase 1 (TAIR:AT4G21540.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
NP_851065.1
  • long-chain base (LCB) kinase 1 (LCBK1); FUNCTIONS IN: diacylglycerol kinase activity, D-erythro-sphingosine kinase activity; INVOLVED IN: activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway, sphingolipid biosynthetic process; LOCATED IN: plasma membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Diacylglycerol kinase, catalytic domain (InterPro:IPR001206); BEST Arabidopsis thaliana protein match is: sphingosine kinase 1 (TAIR:AT4G21540.1); Has 4352 Blast hits to 4113 proteins in 1166 species: Archae - 8; Bacteria - 2944; Metazoa - 550; Fungi - 174; Plants - 282; Viruses - 0; Other Eukaryotes - 394 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    7904293..7909623 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001343803.1 → NP_001331260.1  long-chain base (LCB) kinase 1 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8BDB5, A0A654G3H4

  2. NM_180734.3 → NP_851065.1  long-chain base (LCB) kinase 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_851065.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B9DHC8, Q9FHL3, Q9LRB0
    UniProtKB/TrEMBL
    A0A178UBT3, A0A5S9Y744, A0A654G3H4
    Conserved Domains (2) summary
    COG1597
    Location:249 → 542
    LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]
    pfam00781
    Location:249 → 380
    DAGK_cat; Diacylglycerol kinase catalytic domain

  3. NM_122252.4 → NP_568432.1  long-chain base (LCB) kinase 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_568432.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B9DHC8, Q9FHL3, Q9LRB0
    UniProtKB/TrEMBL
    A0A178UBT3, A0A5S9Y744, A0A654G3H4
    Conserved Domains (2) summary
    COG1597
    Location:249 → 542
    LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]
    pfam00781
    Location:249 → 380
    DAGK_cat; Diacylglycerol kinase catalytic domain

  4. NM_001343804.1 → NP_001331261.1  long-chain base (LCB) kinase 1 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B9DHC8, Q9FHL3, Q9LRB0
    UniProtKB/TrEMBL
    A0A178UBT3, A0A5S9Y744, A0A654G3H4
    Conserved Domains (2) summary
    COG1597
    Location:249 → 542
    LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]
    pfam00781
    Location:249 → 380
    DAGK_cat; Diacylglycerol kinase catalytic domain

  5. NM_001036852.4 → NP_001031929.4  long-chain base (LCB) kinase 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001031929.4

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A654G3H4, B3H501
    Conserved Domains (1) summary
    pfam00781
    Location:249 → 395
    DAGK_cat; Diacylglycerol kinase catalytic domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9LRB0.1

Gene LinkOut

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