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alpha-ADR alpha-adaptin [ Arabidopsis thaliana (thale cress) ]

Gene ID: 832340, updated on 18-Sep-2024

Summary

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Official Symbol
alpha-ADR
Official Full Name
alpha-adaptin
Primary source
TAIR:AT5G22770
Locus tag
AT5G22770
See related
Araport:AT5G22770
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
alpha-adaptin; MDJ22.19; MDJ22_19
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Genomic context

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See alpha-ADR in Genome Data Viewer
Location:
chromosome: 5
Exon count:
28
Sequence:
Chromosome: 5; NC_003076.8 (7579156..7588322, complement)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene DNA/RNA helicase protein Neighboring gene PHD finger family protein Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene Adaptor protein complex AP-2, alpha subunit Neighboring gene uncharacterized protein Neighboring gene reticulata-related 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Adaptor protein complex 2-mediated endocytosis is crucial for male reproductive organ development in Arabidopsis. Kim SY, et al. Plant Cell, 2013 Aug. PMID 23975898, Free PMC Article
  2. Identification and functional characterization of Arabidopsis AP180, a binding partner of plant alphaC-adaptin. Barth M, et al. J Cell Sci, 2004 Apr 15. PMID 15054111
  3. EpsinR2 interacts with clathrin, adaptor protein-3, AtVTI12, and phosphatidylinositol-3-phosphate. Implications for EpsinR2 function in protein trafficking in plant cells. Lee GJ, et al. Plant Physiol, 2007 Apr. PMID 17277094, Free PMC Article
  4. SINAT E3 Ubiquitin Ligases Mediate FREE1 and VPS23A Degradation to Modulate Abscisic Acid Signaling. Xia FN, et al. Plant Cell, 2020 Oct. PMID 32753431, Free PMC Article
  5. The clathrin adaptor complex AP-2 mediates endocytosis of brassinosteroid insensitive1 in Arabidopsis. Di Rubbo S, et al. Plant Cell, 2013 Aug. PMID 23975899, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001343763.1
NM_001343764.1
NM_122183.3
NM_180726.2
NM_180727.2

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables clathrin adaptor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in clathrin-dependent endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in plastid HDA PubMed 

General protein information

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Preferred Names
alpha-adaptin
NP_197669.1
  • alpha-adaptin (alpha-ADR); FUNCTIONS IN: protein transporter activity, binding; INVOLVED IN: intracellular protein transport, vesicle-mediated transport, protein transport; LOCATED IN: plasma membrane, membrane; EXPRESSED IN: male gametophyte, pollen tube, leaf; EXPRESSED DURING: M germinated pollen stage; CONTAINS InterPro DOMAIN/s: Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain (InterPro:IPR008152), Adaptor protein complex AP-2, alpha subunit (InterPro:IPR017104), Armadillo-like helical (InterPro:IPR011989), Clathrin adaptor, alpha-adaptin, appendage, Ig-like subdomain (InterPro:IPR013038), Clathrin/coatomer adaptor, adaptin-like, N-terminal (InterPro:IPR002553), Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain (InterPro:IPR003164), Armadillo-type fold (InterPro:IPR016024), Clathrin alpha-adaptin/coatomer adaptor, appendage, C-terminal subdomain (InterPro:IPR015873), Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain (InterPro:IPR009028), Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain (InterPro:IPR013041); BEST Arabidopsis thaliana protein match is: Adaptor protein complex AP-2, alpha subunit (TAIR:AT5G22780.1); Has 2529 Blast hits to 2470 proteins in 297 species: Archae - 0; Bacteria - 0; Metazoa - 987; Fungi - 687; Plants - 265; Viruses - 0; Other Eukaryotes - 590 (source: NCBI BLink).
NP_851057.1
  • alpha-adaptin (alpha-ADR); FUNCTIONS IN: protein transporter activity, binding; INVOLVED IN: intracellular protein transport, vesicle-mediated transport, protein transport; LOCATED IN: plasma membrane, membrane; EXPRESSED IN: male gametophyte, pollen tube, leaf; EXPRESSED DURING: M germinated pollen stage; CONTAINS InterPro DOMAIN/s: Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain (InterPro:IPR008152), Adaptor protein complex AP-2, alpha subunit (InterPro:IPR017104), Armadillo-like helical (InterPro:IPR011989), Clathrin adaptor, alpha-adaptin, appendage, Ig-like subdomain (InterPro:IPR013038), Clathrin/coatomer adaptor, adaptin-like, N-terminal (InterPro:IPR002553), Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain (InterPro:IPR003164), Armadillo-type fold (InterPro:IPR016024), Clathrin alpha-adaptin/coatomer adaptor, appendage, C-terminal subdomain (InterPro:IPR015873), Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain (InterPro:IPR009028), Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain (InterPro:IPR013041); BEST Arabidopsis thaliana protein match is: Adaptor protein complex AP-2, alpha subunit (TAIR:AT5G22780.1); Has 2529 Blast hits to 2470 proteins in 297 species: Archae - 0; Bacteria - 0; Metazoa - 987; Fungi - 687; Plants - 265; Viruses - 0; Other Eukaryotes - 590 (source: NCBI BLink).
NP_851058.1
  • alpha-adaptin (alpha-ADR); FUNCTIONS IN: protein transporter activity, binding; INVOLVED IN: intracellular protein transport, vesicle-mediated transport, protein transport; LOCATED IN: plasma membrane, membrane; EXPRESSED IN: male gametophyte, pollen tube, leaf; EXPRESSED DURING: M germinated pollen stage; CONTAINS InterPro DOMAIN/s: Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain (InterPro:IPR008152), Adaptor protein complex AP-2, alpha subunit (InterPro:IPR017104), Armadillo-like helical (InterPro:IPR011989), Clathrin adaptor, alpha-adaptin, appendage, Ig-like subdomain (InterPro:IPR013038), Clathrin/coatomer adaptor, adaptin-like, N-terminal (InterPro:IPR002553), Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain (InterPro:IPR003164), Armadillo-type fold (InterPro:IPR016024), Clathrin alpha-adaptin/coatomer adaptor, appendage, C-terminal subdomain (InterPro:IPR015873), Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain (InterPro:IPR009028), Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain (InterPro:IPR013041); BEST Arabidopsis thaliana protein match is: Adaptor protein complex AP-2, alpha subunit (TAIR:AT5G22780.1); Has 2529 Blast hits to 2470 proteins in 297 species: Archae - 0; Bacteria - 0; Metazoa - 987; Fungi - 687; Plants - 265; Viruses - 0; Other Eukaryotes - 590 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    7579156..7588322 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001343762.1 → NP_001330970.1  alpha-adaptin [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    C0Z243, C0Z347, Q8LPL6, Q9FNI4
    UniProtKB/TrEMBL
    A0A178UMB9

  2. NM_180726.2 → NP_851057.1  alpha-adaptin [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_851057.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    C0Z243, C0Z347, Q8LPL6, Q9FNI4
    UniProtKB/TrEMBL
    A0A178UMB9
    Conserved Domains (5) summary
    smart00809
    Location:751 → 844
    Alpha_adaptinC2; Adaptin C-terminal domain
    pfam01602
    Location:23 → 582
    Adaptin_N; Adaptin N terminal region
    pfam02296
    Location:856 → 965
    Alpha_adaptin_C; Alpha adaptin AP2, C-terminal domain
    sd00044
    Location:323 → 347
    HEAT; HEAT repeat [structural motif]
    cl14813
    Location:412 → 561
    GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)

  3. NM_001343763.1 → NP_001330971.1  alpha-adaptin [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    C0Z243, C0Z347, Q8LPL6, Q9FNI4
    UniProtKB/TrEMBL
    A0A178UMB9

  4. NM_001343764.1 → NP_001330969.1  alpha-adaptin [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    C0Z243, C0Z347, Q8LPL6, Q9FNI4
    UniProtKB/TrEMBL
    A0A178UMB9

  5. NM_180727.2 → NP_851058.1  alpha-adaptin [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_851058.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    C0Z243, C0Z347, Q8LPL6, Q9FNI4
    UniProtKB/TrEMBL
    A0A178UMB9
    Conserved Domains (5) summary
    smart00809
    Location:751 → 844
    Alpha_adaptinC2; Adaptin C-terminal domain
    pfam01602
    Location:23 → 582
    Adaptin_N; Adaptin N terminal region
    pfam02296
    Location:856 → 965
    Alpha_adaptin_C; Alpha adaptin AP2, C-terminal domain
    sd00044
    Location:323 → 347
    HEAT; HEAT repeat [structural motif]
    cl14813
    Location:412 → 561
    GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)

  6. NM_122183.3 → NP_197669.1  alpha-adaptin [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_197669.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    C0Z243, C0Z347, Q8LPL6, Q9FNI4
    UniProtKB/TrEMBL
    A0A178UMB9
    Conserved Domains (5) summary
    smart00809
    Location:751 → 844
    Alpha_adaptinC2; Adaptin C-terminal domain
    pfam01602
    Location:23 → 582
    Adaptin_N; Adaptin N terminal region
    pfam02296
    Location:856 → 965
    Alpha_adaptin_C; Alpha adaptin AP2, C-terminal domain
    sd00044
    Location:323 → 347
    HEAT; HEAT repeat [structural motif]
    cl14813
    Location:412 → 561
    GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8LPL6.1

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