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FAR1 fatty acid reductase 1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 832311, updated on 18-Sep-2024

Summary

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Official Symbol
FAR1
Official Full Name
fatty acid reductase 1
Primary source
TAIR:AT5G22500
Locus tag
AT5G22500
See related
Araport:AT5G22500
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
fatty acid reductase 1; MQJ16.4; MQJ16_4
Summary
Encodes a member of the eight-member gene family encoding alcohol-forming fatty acyl-CoA reductases (FARs) identified in Arabidopsis thaliana. Three of the FARs, FAR1 (At5g22500), FAR4 (At3g44540) and FAR5 (At3g44550), are shown to generate the fatty alcohols found in root, seed coat, and wound-induced leaf tissue.
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Genomic context

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See FAR1 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
10
Sequence:
Chromosome: 5; NC_003076.8 (7470328..7474133)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene O-acyltransferase (WSD1-like) family protein Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene alkaline/neutral invertase Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Arabidopsis FHY3 and FAR1 Regulate the Balance between Growth and Defense Responses under Shade Conditions. Liu Y, et al. Plant Cell, 2019 Sep. PMID 31311834, Free PMC Article
  2. Suberin-associated fatty alcohols in Arabidopsis: distributions in roots and contributions to seed coat barrier properties. Vishwanath SJ, et al. Plant Physiol, 2013 Nov. PMID 24019425, Free PMC Article
  3. Three Arabidopsis fatty acyl-coenzyme A reductases, FAR1, FAR4, and FAR5, generate primary fatty alcohols associated with suberin deposition. Domergue F, et al. Plant Physiol, 2010 Aug. PMID 20571114, Free PMC Article
  4. Functional expression of five Arabidopsis fatty acyl-CoA reductase genes in Escherichia coli. Doan TT, et al. J Plant Physiol, 2009 May 15. PMID 19062129
  5. Putative glycosyltransferases and other plant Golgi apparatus proteins are revealed by LOPIT proteomics. Nikolovski N, et al. Plant Physiol, 2012 Oct. PMID 22923678, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Arabidopsis FHY3 and FAR1 Regulate the Balance between Growth and Defense Responses under Shade Conditions.
    Title: Arabidopsis FHY3 and FAR1 Regulate the Balance between Growth and Defense Responses under Shade Conditions.
  2. Data indicate that down-regulation of Arabidopsis FATTY ACYL REDUCTASE1 (FAR1), FAR4, and FAR5, which collectively produce the fatty alcohols found in suberin, reduced their levels by 70% to 80%.
    Title: Suberin-associated fatty alcohols in Arabidopsis: distributions in roots and contributions to seed coat barrier properties.
  3. FAR1, FAR4, and FAR5 generate the fatty alcohols found in root, seed coat, and wound-induced leaf tissue.
    Title: Three Arabidopsis fatty acyl-coenzyme A reductases, FAR1, FAR4, and FAR5, generate primary fatty alcohols associated with suberin deposition.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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NM_001343737.1
NM_122155.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables alcohol-forming long-chain fatty acyl-CoA reductase activity IEA
Inferred from Electronic Annotation
more info
  
enables alcohol-forming very long-chain fatty acyl-CoA reductase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables alcohol-forming very long-chain fatty acyl-CoA reductase activity IEA
Inferred from Electronic Annotation
more info
  
enables long-chain-fatty-acyl-CoA reductase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within response to salt stress IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to wounding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within suberin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast HDA PubMed 
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in plasma membrane HDA PubMed 

General protein information

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Preferred Names
fatty acid reductase 1
NP_197642.1
  • fatty acid reductase 1 (FAR1); FUNCTIONS IN: oxidoreductase activity, acting on the CH-CH group of donors, fatty-acyl-CoA reductase (alcohol-forming) activity, long-chain-fatty-acyl-CoA reductase activity; INVOLVED IN: response to salt stress, microsporogenesis, response to wounding, suberin biosynthetic process; LOCATED IN: chloroplast; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Male sterility (InterPro:IPR004262), NAD(P)-binding domain (InterPro:IPR016040), Male sterility, NAD-binding (InterPro:IPR013120); BEST Arabidopsis thaliana protein match is: fatty acid reductase 4 (TAIR:AT3G44540.1); Has 2592 Blast hits to 2555 proteins in 497 species: Archae - 6; Bacteria - 759; Metazoa - 1002; Fungi - 307; Plants - 285; Viruses - 0; Other Eukaryotes - 233 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    7470328..7474133
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_122155.4 → NP_197642.1  fatty acid reductase 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_197642.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q39152
    UniProtKB/TrEMBL
    A0A5S9Y754
    Conserved Domains (1) summary
    PLN02996
    Location:1 → 490
    PLN02996; fatty acyl-CoA reductase

  2. NM_001343737.1 → NP_001331256.1  fatty acid reductase 1 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8BDD4, A0A5S9Y754
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q39152.1

Gene LinkOut

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