IPP1 isopentenyl diphosphate isomerase 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: IPP1
Official Full Name: isopentenyl diphosphate isomerase 1
Primary source: TAIR:AT5G16440
Locus tag: AT5G16440
See related: Araport:AT5G16440
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ISOPENTENYL DIPHOSPHATE ISOMERASE; isopentenyl diphosphate isomerase 1; MQK4.17; MQK4_17
Summary: Encodes a protein with isopentenyl diphosphate:dimethylallyl diphosphate isomerase activity. There is genetic evidence that it functions in the mevalonate, but not the MEP biosynthetic pathway.
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Genomic context

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See IPP1 in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 6

Sequence:: Chromosome: 5; NC_003076.8 (5371627..5373809)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Each of Arabidopsis IPP2 and IPP1 isomerases is found in multiple but partially overlapping subcellular locations, and each can compensate for the loss of the other through partial redundancy in the cytosol.
Title: The Arabidopsis thaliana type I Isopentenyl Diphosphate Isomerases are targeted to multiple subcellular compartments and have overlapping functions in isoprenoid biosynthesis.
IPI plays a critical role in isoprenoid biosynthesis via the MVA pathway, and IPI is essential for the maintenance of appropriate levels of IPP and DMAPP in different subcellular compartments in plants. [IPI1]
Title: Genetic evidence for the role of isopentenyl diphosphate isomerases in the mevalonate pathway and plant development in Arabidopsis.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_121649.6

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables isopentenyl-diphosphate delta-isomerase activity	IDA Inferred from Direct Assay more info	PubMed
enables isopentenyl-diphosphate delta-isomerase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in chlorophyll biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chlorophyll biosynthetic process	TAS Traceable Author Statement more info	PubMed
involved_in dimethylallyl diphosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within isopentenyl diphosphate biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within isoprenoid biosynthetic process	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	HDA more info	PubMed
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in plastid	HDA more info	PubMed
located_in plastid	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: isopentenyl diphosphate isomerase 1

NP_197148.3

isopentenyl diphosphate isomerase 1 (IPP1); FUNCTIONS IN: isopentenyl-diphosphate delta-isomerase activity; INVOLVED IN: chlorophyll biosynthetic process, isoprenoid biosynthetic process, isopentenyl diphosphate biosynthetic process; LOCATED IN: cytosol, chloroplast, plastid; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: NUDIX hydrolase domain-like (InterPro:IPR015797), NUDIX hydrolase domain (InterPro:IPR000086), Isopentenyl-diphosphate delta-isomerase, type 1 (InterPro:IPR011876); BEST Arabidopsis thaliana protein match is: isopentenyl pyrophosphate:dimethylallyl pyrophosphate isomerase 2 (TAIR:AT3G02780.1); Has 2226 Blast hits to 2225 proteins in 801 species: Archae - 35; Bacteria - 1199; Metazoa - 210; Fungi - 137; Plants - 180; Viruses - 0; Other Eukaryotes - 465 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

5371627..5373809

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_121649.6 → NP_197148.3 isopentenyl diphosphate isomerase 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_197148.3

Status: REVIEWED

UniProtKB/Swiss-Prot

Q38929, Q42552, Q9FFE1

UniProtKB/TrEMBL

A0A178ULI3, A0A5S9Y4N3

Conserved Domains (1) summary

PLN02552
Location:58 → 291

PLN02552; isopentenyl-diphosphate delta-isomerase