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SQE3 squalene epoxidase 3 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 829932, updated on 18-Sep-2024

Summary

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Official Symbol
SQE3
Official Full Name
squalene epoxidase 3
Primary source
TAIR:AT4G37760
Locus tag
AT4G37760
See related
Araport:AT4G37760
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
squalene epoxidase 3; T28I19.40; T28I19_40
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Genomic context

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See SQE3 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
6
Sequence:
Chromosome: 4; NC_003075.7 (17743738..17746697)

Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Integrase-type DNA-binding superfamily protein Neighboring gene 1-amino-cyclopropane-1-carboxylate synthase 8 Neighboring gene myb domain protein 87

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Arabidopsis Squalene Epoxidase 3 (SQE3) Complements SQE1 and Is Important for Embryo Development and Bulk Squalene Epoxidase Activity. Laranjeira S, et al. Mol Plant, 2015 Jul. PMID 25707755
  2. Arabidopsis thaliana squalene epoxidase 1 is essential for root and seed development. Rasbery JM, et al. J Biol Chem, 2007 Jun 8. PMID 17426032
  3. An example of intron junctional sliding in the gene families encoding squalene monooxygenase homologues in Arabidopsis thaliana and Brassica napus. Schäfer UA, et al. Plant Mol Biol, 1999 Mar. PMID 10350086
  4. Expression profiling reveals COI1 to be a key regulator of genes involved in wound- and methyl jasmonate-induced secondary metabolism, defence, and hormone interactions. Devoto A, et al. Plant Mol Biol, 2005 Jul. PMID 16021335
  5. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SQE1 and SQE3 seem to be two functionally unequal redundant genes in the promotion of plant SQE activity in Arabidopsis
    Title: Arabidopsis Squalene Epoxidase 3 (SQE3) Complements SQE1 and Is Important for Embryo Development and Bulk Squalene Epoxidase Activity.
  2. isolated and characterized Arabidopsis sqe1 mutants and discovered severe developmental defects, including reduced root and hypocotyl elongation
    Title: Arabidopsis thaliana squalene epoxidase 1 is essential for root and seed development.
Submit: New GeneRIF Correction

General gene information

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Homology

NM_119938.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables squalene monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables squalene monooxygenase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within response to jasmonic acid IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to wounding IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within sterol biosynthetic process TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
squalene epoxidase 3
NP_568033.1
  • squalene epoxidase 3 (SQE3); FUNCTIONS IN: squalene monooxygenase activity; INVOLVED IN: response to jasmonic acid stimulus, response to wounding, sterol biosynthetic process; LOCATED IN: endomembrane system, integral to membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Squalene epoxidase (InterPro:IPR013698), Fumarate reductase/succinate dehydrogenase flavoprotein, N-terminal (InterPro:IPR003953); BEST Arabidopsis thaliana protein match is: squalene epoxidase 2 (TAIR:AT2G22830.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003075.7 Reference assembly

    Range
    17743738..17746697
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_119938.4 → NP_568033.1  squalene epoxidase 3 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_568033.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8VYH2, Q9T064
    UniProtKB/TrEMBL
    A0A178UU38, A0A5S9XZX1, A0A654FWX8
    Conserved Domains (2) summary
    COG0654
    Location:69 → 432
    UbiH; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]
    pfam08491
    Location:205 → 478
    SE; Squalene epoxidase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VYH2.1

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