U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

MCCB 3-methylcrotonyl-CoA carboxylase [ Arabidopsis thaliana (thale cress) ]

Gene ID: 829549, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
MCCB
Official Full Name
3-methylcrotonyl-CoA carboxylase
Primary source
TAIR:AT4G34030
Locus tag
AT4G34030
See related
Araport:AT4G34030
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
3-methylcrotonyl-CoA carboxylase; 3-METHYLCROTONYL-COA CARBOXYLASE; F28A23.210; F28A23_210
Summary
MCC-B is involved in leucine degradation in mitochondria. The active protein is a dimer of MCC-A and MCC-B. MCC-A is biotinylated whereas MCC-B is not.
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See MCCB in Genome Data Viewer
Location:
chromosome: 4
Exon count:
10
Sequence:
Chromosome: 4; NC_003075.7 (16301027..16304099)

Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene abscisic acid responsive elements-binding factor 3 Neighboring gene Class I glutamine amidotransferase-like superfamily protein Neighboring gene tRNA-Arg Neighboring gene RING/U-box superfamily protein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Genetic dissection of methylcrotonyl CoA carboxylase indicates a complex role for mitochondrial leucine catabolism during seed development and germination. Ding G, et al. Plant J, 2012 May. PMID 22211474
  2. Metabolic and environmental regulation of 3-methylcrotonyl-coenzyme A carboxylase expression in Arabidopsis. Che P, et al. Plant Physiol, 2002 Jun. PMID 12068107, Free PMC Article
  3. Lipoic acid-dependent oxidative catabolism of alpha-keto acids in mitochondria provides evidence for branched-chain amino acid catabolism in Arabidopsis. Taylor NL, et al. Plant Physiol, 2004 Feb. PMID 14764908, Free PMC Article
  4. Heterogeneity of the mitochondrial proteome for photosynthetic and non-photosynthetic Arabidopsis metabolism. Lee CP, et al. Mol Cell Proteomics, 2008 Jul. PMID 18385124
  5. Divalent metal ions in plant mitochondria and their role in interactions with proteins and oxidative stress-induced damage to respiratory function. Tan YF, et al. Plant Physiol, 2010 Feb. PMID 20018591, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Studies indicate that mutations in either 3-methylcrotonyl CoA carboxylase MCCA (At1g03090) or MCCB (At4g34030) block mitochondrial Leu catabolism, as inferred from the increased accumulation of Leu.
    Title: Genetic dissection of methylcrotonyl CoA carboxylase indicates a complex role for mitochondrial leucine catabolism during seed development and germination.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

NM_119564.5

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables cobalt ion binding HDA PubMed 
enables methylcrotonoyl-CoA carboxylase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding HDA PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within L-leucine catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in L-leucine catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISM
Inferred from Sequence Model
more info
  
located_in mitochondrion TAS
Traceable Author Statement
more info
 PubMed 
located_in plasma membrane HDA PubMed 

General protein information

Go to the top of the page Help
Preferred Names
3-methylcrotonyl-CoA carboxylase
NP_567950.1
  • 3-methylcrotonyl-CoA carboxylase (MCCB); FUNCTIONS IN: biotin carboxylase activity, cobalt ion binding, methylcrotonoyl-CoA carboxylase activity, zinc ion binding; INVOLVED IN: leucine catabolic process; LOCATED IN: mitochondrion, mitochondrial matrix; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Acetyl-coenzyme A carboxyltransferase, N-terminal (InterPro:IPR011762), Carboxyl transferase (InterPro:IPR000022), Acetyl-coenzyme A carboxyltransferase, C-terminal (InterPro:IPR011763); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003075.7 Reference assembly

    Range
    16301027..16304099
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_119564.5 → NP_567950.1  3-methylcrotonyl-CoA carboxylase [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_567950.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O49501, Q94F35, Q9LDD8
    UniProtKB/TrEMBL
    A0A178UTZ4, A0A5S9XZB3, A0A7G2F5W2
    Conserved Domains (1) summary
    PLN02820
    Location:19 → 587
    PLN02820; 3-methylcrotonyl-CoA carboxylase, beta chain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9LDD8.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools