MGD1 monogalactosyl diacylglycerol synthase 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: MGD1
Official Full Name: monogalactosyl diacylglycerol synthase 1
Primary source: TAIR:AT4G31780
Locus tag: AT4G31780
See related: Araport:AT4G31780
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: EMB2797; EMBRYO DEFECTIVE 2797; F11C18.2; MGDA; monogalactosyl diacylglycerol synthase 1; MONOGALACTOSYLDIACYLGLYCEROL SYNTHASE; MONOGALACTOSYLDIACYLGLYCEROL SYNTHASE A; UDP-glycosyl transferase 81A1; UGT81A1
Summary: Encodes an A-type monogalactosyldiacylglycerol (MGDG) synthase. It represents the isoform responsible for the bulk of MGDG synthesis in Arabidopsis.
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Genomic context

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See MGD1 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 8

Sequence:: Chromosome: 4; NC_003075.7 (15373988..15377172)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mechanism of activation of plant monogalactosyldiacylglycerol synthase 1 (MGD1) by phosphatidylglycerol.
Title: Mechanism of activation of plant monogalactosyldiacylglycerol synthase 1 (MGD1) by phosphatidylglycerol.
Data show that Monogalactosyldiacylglycerol (MGDG) synthase 1 (MGD1) has a long and flexible region (approximately 50 amino acids) that is required for diacylglycerol (DAG) binding.
Title: Structural insights and membrane binding properties of MGD1, the major galactolipid synthase in plants.
MGD1 function may link galactolipid synthesis with the coordinated transcriptional regulation of chloroplasts and other organelles during cotyledon greening.
Title: Inducible knockdown of MONOGALACTOSYLDIACYLGLYCEROL SYNTHASE1 reveals roles of galactolipids in organelle differentiation in Arabidopsis cotyledons.
A role of these lipids on the localization of MGD1 in specific domains.
Title: The influence of lipids on MGD1 membrane binding highlights novel mechanisms for galactolipid biosynthesis regulation in chloroplasts.

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Pathways from PubChem

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General gene information

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NM_001342113.1

Supported by ESTs:

NM_001342114.1

Supported by ESTs:

NM_119327.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables 1,2-diacylglycerol 3-beta-galactosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables 1,2-diacylglycerol 3-beta-galactosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables 1,2-diacylglycerol 3-beta-galactosyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables UDP-galactosyltransferase activity	TAS Traceable Author Statement more info	PubMed
enables UDP-glycosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables glycosyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within embryo development ending in seed dormancy	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within galactolipid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within glycolipid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in glycolipid biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within thylakoid membrane organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in chloroplast envelope	HDA more info	PubMed
located_in chloroplast envelope	IMP Inferred from Mutant Phenotype more info	PubMed
located_in chloroplast inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	HDA more info	PubMed
located_in plastid	HDA more info	PubMed

General protein information

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Preferred Names: monogalactosyl diacylglycerol synthase 1

NP_001320109.1

monogalactosyl diacylglycerol synthase 1 (MGD1); FUNCTIONS IN: UDP-glycosyltransferase activity, 1,2-diacylglycerol 3-beta-galactosyltransferase activity, transferase activity, transferring glycosyl groups, UDP-galactosyltransferase activity; INVOLVED IN: thylakoid membrane organization, glycolipid biosynthetic process, galactolipid biosynthetic process, embryo development; LOCATED IN: chloroplast inner membrane, chloroplast envelope; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Monogalactosyldiacylglycerol synthase (InterPro:IPR009695), Glycosyl transferase, family 28, C-terminal (InterPro:IPR007235); BEST Arabidopsis thaliana protein match is: monogalactosyldiacylglycerol synthase type C (TAIR:AT2G11810.1); Has 1828 Blast hits to 1828 proteins in 656 species: Archae - 0; Bacteria - 1628; Metazoa - 0; Fungi - 0; Plants - 105; Viruses - 0; Other Eukaryotes - 95 (source: NCBI BLink).

NP_194906.1

monogalactosyl diacylglycerol synthase 1 (MGD1); FUNCTIONS IN: UDP-glycosyltransferase activity, 1,2-diacylglycerol 3-beta-galactosyltransferase activity, transferase activity, transferring glycosyl groups, UDP-galactosyltransferase activity; INVOLVED IN: thylakoid membrane organization, glycolipid biosynthetic process, galactolipid biosynthetic process, embryo development; LOCATED IN: chloroplast inner membrane, chloroplast envelope; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Glycosyl transferase, family 28, C-terminal (InterPro:IPR007235), Monogalactosyldiacylglycerol synthase (InterPro:IPR009695); BEST Arabidopsis thaliana protein match is: monogalactosyldiacylglycerol synthase type C (TAIR:AT2G11810.1); Has 2406 Blast hits to 2406 proteins in 811 species: Archae - 0; Bacteria - 2169; Metazoa - 0; Fungi - 0; Plants - 110; Viruses - 0; Other Eukaryotes - 127 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

15373988..15377172

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001342113.1 → NP_001320109.1 monogalactosyl diacylglycerol synthase 1 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A2H1ZEP5
NM_001342114.1 → NP_001329161.1 monogalactosyl diacylglycerol synthase 1 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178V7B8, A0A1P8B6W3
NM_119327.3 → NP_194906.1 monogalactosyl diacylglycerol synthase 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_194906.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O81770, Q3E9T1, Q9MU68, W8Q2X7

UniProtKB/TrEMBL

A0A178V7B8

Conserved Domains (3) summary

PLN02605
Location:144 → 523

PLN02605; monogalactosyldiacylglycerol synthase

pfam06925
Location:155 → 323

MGDG_synth; Monogalactosyldiacylglycerol (MGDG) synthase

cl10013
Location:287 → 513

Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...