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FAD6 fatty acid desaturase 6 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 829220, updated on 18-Sep-2024

Summary

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Official Symbol
FAD6
Official Full Name
fatty acid desaturase 6
Primary source
TAIR:AT4G30950
Locus tag
AT4G30950
See related
Araport:AT4G30950
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
CHLOROPLAST PRECURSOR; F6I18.140; F6I18_140; FADC; fatty acid desaturase 6; FATTY ACID DESATURASE C; OMEGA-6 FATTY ACID DESATURASE; SFD4; STEAROYL DESATURASE DEFICIENCY 4
Summary
Chloroplastic enzyme responsible for the synthesis of 16:2 and 18:2 fatty acids from galactolipids, sulpholipids and phosphatidylglycerol. Uses ferredoxin as electron donor. Gene mutation resulted in reduced level of unsaturated fatty acids leading to susceptibility to photoinhibition.
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Genomic context

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See FAD6 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
10
Sequence:
Chromosome: 4; NC_003075.7 (15056975..15059846, complement)

Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene WRKY DNA-binding protein 32 Neighboring gene BTB/POZ domain with WD40/YVTN repeat-like protein Neighboring gene ncRNA Neighboring gene SOS3-interacting protein 3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Fatty acid desaturase-6 (Fad6) is required for salt tolerance in Arabidopsis thaliana. Zhang JT, et al. Biochem Biophys Res Commun, 2009 Dec 18. PMID 19799856
  2. Arabidopsis sfd mutants affect plastidic lipid composition and suppress dwarfing, cell death, and the enhanced disease resistance phenotypes resulting from the deficiency of a fatty acid desaturase. Nandi A, et al. Plant Cell, 2003 Oct. PMID 14507997, Free PMC Article
  3. Identification of a gene that complements an Arabidopsis mutant deficient in chloroplast omega 6 desaturase activity. Falcone DL, et al. Plant Physiol, 1994 Dec. PMID 7846158, Free PMC Article
  4. Genetic analysis of Arabidopsis mutants impaired in plastid lipid import reveals a role of membrane lipids in chloroplast division. Fan J, et al. Plant Signal Behav, 2011 Mar. PMID 21358271, Free PMC Article
  5. Photoinhibition in mutants of Arabidopsis deficient in thylakoid unsaturation. Vijayan P, et al. Plant Physiol, 2002 Jun. PMID 12068126, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The tgd1-1 fad6 and tgd4-3 fad6 double mutants were deficient in polyunsaturated fatty acids in chloroplast membrane lipids, and severely compromised in the biogenesis of photosynthetic membrane systems.
    Title: Genetic analysis of Arabidopsis mutants impaired in plastid lipid import reveals a role of membrane lipids in chloroplast division.
  2. All these results suggest that Fad6 is required for salt resistance in Arabidopsis.
    Title: Fatty acid desaturase-6 (Fad6) is required for salt tolerance in Arabidopsis thaliana.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_119243.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables acyl-lipid (n+3)-(Z)-desaturase (ferredoxin) activity IEA
Inferred from Electronic Annotation
more info
  
enables omega-6 fatty acid desaturase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within fatty acid biosynthetic process TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within photoinhibition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in unsaturated fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in chloroplast HDA PubMed 
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in chloroplast NAS
Non-traceable Author Statement
more info
 PubMed 
located_in chloroplast envelope HDA PubMed 
located_in plasma membrane HDA PubMed 

General protein information

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Preferred Names
fatty acid desaturase 6
NP_194824.1
  • fatty acid desaturase 6 (FAD6); FUNCTIONS IN: omega-6 fatty acid desaturase activity; INVOLVED IN: photoinhibition, fatty acid biosynthetic process; LOCATED IN: chloroplast, chloroplast envelope; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Fatty acid desaturase, type 1 (InterPro:IPR005804); BEST Arabidopsis thaliana protein match is: fatty acid desaturase 8 (TAIR:AT5G05580.1); Has 3227 Blast hits to 3218 proteins in 733 species: Archae - 0; Bacteria - 1371; Metazoa - 67; Fungi - 380; Plants - 896; Viruses - 0; Other Eukaryotes - 513 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003075.7 Reference assembly

    Range
    15056975..15059846 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_119243.4 → NP_194824.1  fatty acid desaturase 6 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_194824.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P46312, Q9M094
    UniProtKB/TrEMBL
    A0A178V0M7, A0A5S9XXF6
    Conserved Domains (1) summary
    PLN02598
    Location:1 → 447
    PLN02598; omega-6 fatty acid desaturase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P46312.2

Gene LinkOut

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